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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


ASSUMPCAO, Carmen Regina Leal de. Premature ovarian failure. Arq Bras Endocrinol Metab [online]. 2014, vol.58, n.2, pp.132-143. ISSN 1677-9487.

This article is a review on different aspects of premature ovarian failure (POF) defined as the development of hypogonadism in women before 40 years of age. The review will discuss the etiopathogeny, autoimmune and iatrogenic causes, abnormalities of chromosome X, as well as clinical manifestations, diagnosis, and treatment. Most of the women with this disorder do not have menstrual history, specific of POF development, but infertility associated with the diagnosis is the most problematic aspect of the disease. Arq Bras Endocrinol Metab. 2014;58(2):132-43

Keywords : Ovarian failure; premature ovarian failure; premature menopause; infertility.

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