SciELO - Scientific Electronic Library Online

vol.75 issue1Ultrasonographic findings in ocular toxocariasisNerve fiber layer in glaucomatous hemifield loss: a case-control study with time- and spectral-domain optical coherence tomography author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749


TORRES, Rogil José de Almeida et al. Increase of choroidal and scleral MCP-1 expression in hypercholesterolemia experimental model. Arq. Bras. Oftalmol. [online]. 2012, vol.75, n.1, pp.48-52. ISSN 0004-2749.

PURPOSE: The aim of this study is to experientially demonstrate that a cholesterol-enriched diet induces an increase in the MCP-1 expression in the choroid and sclera. METHOD: New Zealand rabbits were divided into two groups: GN (normal diet group) of 8 rabbits (8 eyes) was fed a standard rabbit diet for 4 weeks; GH (hypercholesterolemic group) of 13 rabbits (13 eyes) was fed a 1% cholesterol enriched diet for 8 weeks. Total serum cholesterol, triglyceride, HDL cholesterol and fasting blood glucose exams were performed at the start of the experiment and at the euthanasia time. After GH 8th week and GN 4th week animals were euthanized and their eyes underwent immunohistochemical analysis with the anti-MCP-1 antibody. RESULTS: The diet has induced a significant increase in GH total cholesterol and triglyceride levels when compared with NG (p<0.001). There was a significant increase in the MCP-1 expression in GH choroid and sclera in relation to GN (p<0.001). CONCLUSION: This study has revealed that the hypercholesterolemic diet in rabbits induces an increase in the MCP-1 expression in the choroid and sclera.

Keywords : Macrophage activation; Macular degeneration; Atherosclerosis; Cholesterol; Choroid; sclera; Monocyte chemoattractant proteins; Animals; Rabbits.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License