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Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749

Abstract

ALMEIDA JUNIOR, Gildásio C. et al. Preoperative tranilast as adjunctive therapy to primary pterygium surgery with a 1-year follow-up. Arq. Bras. Oftalmol. [online]. 2015, vol.78, n.1, pp.1-5. ISSN 0004-2749.  http://dx.doi.org/10.5935/0004-2749.20150002.

Purpose:

To determine the efficacy of tranilast as an adjunctive therapy in conjunctival autograft.

Methods:

Twenty-nine patients were randomly allocated to the Tranilast Group (n=15) or the Control Group (n=14). The Tranilast Group received a subconjunctival injection of 0.5% tranilast 30 days prior to surgery. Conjunctival autograft was performed in both groups using fibrin sealant and 0.02% subconjunctival mitomycin C at the end of the surgery. After the resection of the pterygium, immunohistochemistry was performed with 100 cells to identify epithelial cells positive for transforming growth factor-β (TGF-β). Subjective symptoms were evaluated using a 5-point scale, and the recurrence rate was assessed.

Results:

Both groups showed improvements in their symptoms and similar clinical results. Compared with the Control Group, the Tranilast Group failed to show a decreased recurrence rate (p=0.59). However, the number of epithelial cells expressing TGF-β was lower in the Tranilast Group (5 cells; 95% CI: 2.56-13.15; Control Group, 16 cells, 95% CI: 11.53-24.76; p=0.01). Minimal but reversible complications, including glaucoma secondary to corticosteroids and granuloma, occurred during the study.

Conclusion:

Tranilast was effective in decreasing the number of pterygium epithelial cells expressing TGF-β.

Keywords : Transforming growth factor beta 1; Pterygium/therapy; Recurrence; Autografts; Anti-allergic agents/therapeutic use; Transplantation, autologous; Conjunctiva/ surgery.

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