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Revista de Saúde Pública

versão impressa ISSN 0034-8910versão On-line ISSN 1518-8787

Resumo

GUERRA JUNIOR, Augusto Afonso et al. Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. Rev. Saúde Pública [online]. 2015, vol.49, 13.  Epub 27-Fev-2015. ISSN 1518-8787.  https://doi.org/10.1590/S0034-8910.2015049005430.

OBJECTIVE

To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.

METHODS

This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.

RESULTS

Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.

CONCLUSIONS

After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective.

Palavras-chave : Immunosuppressive Agents; therapeutic use; Kidney Transplantation; economics; Graft Survival; Transplantation Tolerance; drug effects; Cost-Benefit Analysis; Unified Health System; Cohort Studies.

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