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Revista de Saúde Pública

Print version ISSN 0034-8910On-line version ISSN 1518-8787

Abstract

AMORIM, Juleimar Soares Coelho de et al. Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. Rev. Saúde Pública [online]. 2019, vol.53, 35.  Epub Apr 01, 2019. ISSN 1518-8787.  https://doi.org/10.11606/s1518-8787.2019053000855.

OBJECTIVE

Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí.

METHODS

Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI).

RESULTS

The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04–2.03), CCL5 (OR = 1.38, 95%CI 1.01–1.90) and CXCL9 (OR = 1.43, 95%CI 1.02–2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02–2.12) and three (OR = 2.08, 95%CI 1.12–3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively.

CONCLUSIONS

Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people.

Keywords : Aged; Aging; Accidental Falls; Risk Factors; Biomarkers; Inflammation Mediators.

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