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vol.106 suppl.1Biomarkers for susceptibility to infection and disease severity in human malariaSurface-expressed enolases of Plasmodium and other pathogens índice de autoresíndice de materiabúsqueda de artículos
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Memórias do Instituto Oswaldo Cruz

versión impresa ISSN 0074-0276


COSTA, Fabio TM et al. On cytoadhesion of Plasmodium vivax: raison d'être?. Mem. Inst. Oswaldo Cruz [online]. 2011, vol.106, suppl.1, pp.79-84. ISSN 0074-0276.

It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.

Palabras clave : Plasmodium vivax; malaria; cytoadherence; severe disease.

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