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Memórias do Instituto Oswaldo Cruz

versión impresa ISSN 0074-0276

Resumen

FERNANDEZ-BECERRA, Carmen et al. Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection. Mem. Inst. Oswaldo Cruz [online]. 2013, vol.108, n.6, pp.801-803. ISSN 0074-0276.  https://doi.org/10.1590/0074-0276108062013019.

The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.

Palabras clave : CD34+ human haematopoietic stem cells; NIH 3T3 cells; Plasmodium.

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