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Brazilian Journal of Nephrology

Print version ISSN 0101-2800On-line version ISSN 2175-8239


MOLIN, Christine Zomer Dal  and  TREVISOL, Daisson José. Persistent severe hypokalemia: Gitelman syndrome and differential diagnosis. J. Bras. Nefrol. [online]. 2017, vol.39, n.3, pp.337-340. ISSN 2175-8239.

The main causes of hypokalemia are usually evident in the clinical history of patients, with previous episodes of vomiting, diarrhea or diuretic use. However, in some patients the cause of hypokalemia can become a challenge. In such cases, two major components of the investigation must be performed: assessment of urinary excretion potassium and the acid-base status. This article presents a case report of a patient with severe persistent hypokalemia, complementary laboratory tests indicated that's it was hypomagnesaemia and hypocalciuria associated with metabolic alkalosis, and increase of thyroid hormones. Thyrotoxic periodic paralysis was included in the differential diagnosis, but evolved into euthyroid state, persisting with severe hypokalemia, which led to be diagnosed as Gitelman syndrome.

Keywords : hypokalemia; Gitelman syndrome; hyperthyroidism; hypokalemic periodic paralysis.

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