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Revista Brasileira de Farmacognosia

versão impressa ISSN 0102-695Xversão On-line ISSN 1981-528X

Resumo

MA, Qinge et al. Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro. Rev. bras. farmacogn. [online]. 2016, vol.26, n.6, pp.710-713. ISSN 1981-528X.  https://doi.org/10.1016/j.bjp.2016.06.006.

Two new flavonoids (1 and 2), named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids (3–9) were isolated from the aerial parts of Capsella bursa-pastoris (L.) Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds (1–9) were identified by their spectroscopic data and references. Moreover, compounds (1–9) were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2, 3, 6, and 9 (10 µM) exhibited moderate hepatoprotective activities.

Palavras-chave : 5-Hydroxymethyl flavonoid; NMR; HR-ESI-MS; Spectral data; In vitro; Hepatoprotective activity.

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