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Acta Cirúrgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


MIRANDA, Luiz Eduardo C.; VIARO, Fernanda; CENEVIVA, Reginaldo  and  EVORA, Paulo Roberto B.. The experimental basis of hepatic ischemia-reperfusion injury: review. Acta Cir. Bras. [online]. 2004, vol.19, n.1, pp.1-12. ISSN 1678-2674.

Hepatic transplantation has become the main treatment for patients with terminal hepatic disease. Whatever the success of such surgery, the hepatic dysfunction associated with liver transplantation is an important cause of morbidity and mortality. Paradoxically, on restoring the blood supply, the liver is subjected to a further insult, aggravating the injury already caused by ischemia. This complex phenomenon is termed ischemia-reperfusion injury and involves endothelial cell dysfunction, leukocyte entrapment, platelet aggregation, oxidant stress and hepatic microcirculatory perfusion failure. This review discusses the physiopathlogicals mechanisms of liver ischemia-reperfusion injury.

Keywords : Ischemia-reperfusion injury; Liver.

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