SciELO - Scientific Electronic Library Online

 
vol.30 issue11Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats1Remifentanil protects uterus against ischemia-reperfusion injury in rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

CAVALCANTE, Fernanda Paula et al. Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury. Acta Cir. Bras. [online]. 2015, vol.30, n.11, pp.749-755. ISSN 1678-2674.  https://doi.org/10.1590/S0102-865020150110000005.

PURPOSE:

To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect.

METHODS:

Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h: one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis factor-a, and interleukins 6 and 10 were measured. Analyses of mitochondrial oxidation and phosphorylation, malondialdehyde content, histology, and pulmonary vascular permeability were performed.

RESULTS:

Serum levels of alanine and aspartate aminotransferases were significantly lower in the sevoflurane group compared to untreated controls (p<0.05). The sevoflurane group also showed preservation of liver mitochondrial function compared to untreated controls (p<0.05). Sevoflurane administration did not alter increases in serum levels of tumor necrosis factor-a, and interleukins 6 and 10. Sevoflurane treatment significantly reduced the coagulative necrosis induced by ischemia/reperfusion (p<0.05). Pulmonary vascular permeability was preserved in the sevoflurane group compared to untreated controls.

CONCLUSION:

Sevoflurane administration protects the liver against ischemia/reperfusion injury, via preservation of mitochondrial function, and also preserves lung vascular permeability.

Keywords : Ischemia; Reperfusion; Liver; Lung; Cytokines; Rats.

        · text in English     · English ( pdf )