SciELO - Scientific Electronic Library Online

 
vol.32 issue10The role of histone deacetylase inhibitors in regulation of Akt/GSK-3β signaling pathway in mice following transient focal cerebral ischemiaComparative study of respiratory muscle strength in women undergoing conventional and single-port laparoscopic cholecystectomy author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

CAPELO, Isabelle Oliveira Jatai et al. Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats. Acta Cir. Bras. [online]. 2017, vol.32, n.10, pp.873-880. ISSN 1678-2674.  https://doi.org/10.1590/s0102-865020170100000009.

Purpose:

To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity.

Methods:

Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP: 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days.

Results:

It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals. The mortality rate was comparable with that previously reported in the literature. The auditory threshold of animals in the DEXA15 + CDDP group was not significantly altered after exposure to CDDP. The stria vascularis of animals in the DEXA15 + CDDP group was partially preserved after CDDP exposure.

Conclusions:

Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. However, dexamethasone did not protect against systemic toxicity.

Keywords : Dexamethasone; Cisplatin; Rats.

        · text in English     · English ( pdf )