SciELO - Scientific Electronic Library Online

 
vol.14 issue2Analytical performance of an inductively coupled plasma optical emission spectrometry with Dual View configurationLC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053On-line version ISSN 1678-4790

Abstract

TEIXEIRA, Marcos F. S. et al. Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper(II) hexacyanoferrate(III) modified carbon paste electrode. J. Braz. Chem. Soc. [online]. 2003, vol.14, n.2, pp.316-321. ISSN 1678-4790.  https://doi.org/10.1590/S0103-50532003000200021.

A copper(II) hexacyanoferrate(III) (CuHCF) modified carbon paste electrode was used for the electroanalytical determination of pyridoxine (vitamin B6) in pharmaceutical preparations, using cyclic voltammetry. Diverse parameters were investigated for the optimization of the sensor response, such as composition of the electrode, electrolytic solution, effect of pH, scan rate of potential and interferences. The optimum conditions were found at an electrode composition of 20% CuHCF, 55% graphite and 25% mineral oil (m/m) in an acetate buffer (pH 5.5) containing 0.05 mol L-1 of NaCl. The range of determination of pyridoxine was from 1.2 x 10-6 to 6.9 x 10-4 mol L-1. The procedure was successfully applied to the determination of vitamin B6 in formulation preparations. The CuHCF modified carbon paste electrode gave results comparable to those obtained using spectrophotometry.

Keywords : modified carbon paste electrode; copper(II) hexacyanoferrate(III); voltammetric determination; pharmaceutical preparations.

        · abstract in Portuguese     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License