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Ciência Rural

Print version ISSN 0103-8478On-line version ISSN 1678-4596


NATALINI, Cláudio Corrêa  and  LINARDI, Renata Lehn. Identification of multi-drug resistance gene (MDR1) in equine ileum. Cienc. Rural [online]. 2006, vol.36, n.1, pp.298-300. ISSN 1678-4596.

P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.

Keywords : molecular biology; opioids; equine; gene; MDR1; ABCB1.

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