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Print version ISSN 0104-1428On-line version ISSN 1678-5169


IIDA, Aline Sayuri Lima et al. Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol. Polímeros [online]. 2019, vol.29, n.4, e2019049.  Epub Apr 06, 2020. ISSN 1678-5169.

Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy.

Keywords : liposomes; cholecalciferol; lecithin; encapsulation; vitamin stability.

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