SciELO - Scientific Electronic Library Online

 
vol.66 issue8The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal diseaseThe south american context of diagnostic disclosure of adolescents infected by HIV/AIDS: a systematic literature review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista da Associação Médica Brasileira

Print version ISSN 0104-4230On-line version ISSN 1806-9282

Abstract

SILVA FILHO, Agnaldo Lopes da et al. Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety. Rev. Assoc. Med. Bras. [online]. 2020, vol.66, n.8, pp.1134-1138.  Epub Sep 11, 2020. ISSN 1806-9282.  https://doi.org/10.1590/1806-9282.66.8.1134.

Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.

Keywords : Mutation; Estrogen replacement therapy; Salpingostomy; Ovariectomy; Salpingo-oophorectomy; Breast neoplasms; Ovarian neoplasms.

        · abstract in Portuguese     · text in English     · English ( pdf )