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Anais Brasileiros de Dermatologia

versão impressa ISSN 0365-0596

Resumo

PEREZ, Erick Gomes et al. Tuberous sclerosis: evaluation of myofibroblasts in cutaneous angiofibromas - case report. An. Bras. Dermatol. [online]. 2010, vol.85, n.1, pp.84-88. ISSN 0365-0596.  https://doi.org/10.1590/S0365-05962010000100013.

Tuberous sclerosis is a rare autosomal dominant disorder. Myofibroblasts are cells with a hybrid phenotype between fibroblasts and smooth muscle cells. The objective of this study is to describe clinical and histopathological characteristics of tuberous sclerosis and to conduct an immunohistochemical evaluation of myofibroblasts in cutaneous angiofibromas present in this condition. Lesion sections removed were stained with hematoxylin-eosin and Masson's trichrome. Immunohistochemistry against α-SMA was done to determine the presence of myofibroblasts, and the reaction was negative. Since α-SMA is a specific marker for myofibroblasts, this result suggests that myofibroblasts are not involved in cutaneous angiofibromas present in the tuberous sclerosis case reported.

Palavras-chave : Angiofibroma; Genetics; Tuberous sclerosis.

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