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Brazilian Journal of Infectious Diseases

Print version ISSN 1413-8670On-line version ISSN 1678-4391


MARCONDES, Jackson  and  HANSEN, Ekkehard. Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg. Braz J Infect Dis [online]. 2008, vol.12, n.6, pp.469-471. ISSN 1678-4391.

The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety "Vitória de Verão" genetically modified.

Keywords : Edible vaccine; Hepatitis B; Oral immunization; Recombinant antigen; Transgenic plants.

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