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Brazilian Journal of Infectious Diseases

Print version ISSN 1413-8670On-line version ISSN 1678-4391


CORDEIRO, Cynthia Azeredo et al. Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis. Braz J Infect Dis [online]. 2017, vol.21, n.2, pp.176-179. ISSN 1678-4391.

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.


Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.


BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.


BDNF may be released in the context of the active TR inflammatory response.

Keywords : Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.

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