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Brazilian Journal of Infectious Diseases

Print version ISSN 1413-8670On-line version ISSN 1678-4391

Abstract

CORDEIRO, Cynthia Azeredo et al. Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis. Braz J Infect Dis [online]. 2017, vol.21, n.2, pp.176-179. ISSN 1678-4391.  https://doi.org/10.1016/j.bjid.2016.11.005.

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.

Methods:

Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.

Results:

BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.

Conclusion:

BDNF may be released in the context of the active TR inflammatory response.

Keywords : Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.

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