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Revista Brasileira de Hematologia e Hemoterapia

Print version ISSN 1516-8484

Abstract

SILVA, Silvia Fernandes Ribeiro da et al. Red blood cell and leukocyte alloimmunization in patients awaiting kidney transplantation. Rev. Bras. Hematol. Hemoter. [online]. 2013, vol.35, n.3, pp.185-188. ISSN 1516-8484.  https://doi.org/10.5581/1516-8484.20130043.

Objective:

To determine the rates of red blood cell and leukocyte alloimmunization in patients with chronic kidney disease awaiting kidney transplantation.

Methods:

In this cross-sectional and prospective study, the serum of 393 chronic kidney disease patients on a transplant waiting list in Ceará, Northeastern Brazil were tested for red cell and leukocyte antibodies. In addition, demographic, clinical and laboratory data were collected.

Results:

The average age in the sample of 393 patients was 34.1 ± 14 years. Slightly more than half (208; 52.9%) were male. The average numbers of transfusions and gestations were 3.1 ± 3.3 and 1.6 ± 6, respectively. One third (33.6%) were alloimmunized: 78% with leukocyte antibodies, 9.1% with red cell antibodies and 12.9% with both. Red cell antibodies were detected in 29 cases (7.4%), 17 of whom were women, who had received more transfusions than the males (p-value < 0.0001). The most frequently detected red cell antibodies belonged to the Rh (24.1%) and Kell (13.8%) blood group systems. Leukocyte antibodies were detected in 30.5% of cases, 83 of whom were women, who had received more transfusions than the males (p-value < 0.0001) and were more reactive to panel reactive antibodies (p-value < 0.0001). The mean alloreactivity to panel reactive antibodies was 47.7 ± 31.2%.

Conclusion:

Chronic kidney disease patients on the transplant waiting list in Ceará, Brazil, display high rates of red cell (7.4%) and leukocyte (30.5%) alloimmunization. In this sample, alloimmunization was significantly associated with the number of transfusions and gender.

Keywords : Kidney failure, chronic; Blood transfusion; Kidney transplantation; Antibodies; Erythrocyte transfusion; Cross-sectional studies.

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