SciELO - Scientific Electronic Library Online

vol.35 issue3The importance of hemovigilance in the transmission of infectious diseasesThe utility of lactate dehydrogenase in the follow up of patients with diffuse large B-cell lymphoma author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Hematologia e Hemoterapia

Print version ISSN 1516-8484


SILVA, Silvia Fernandes Ribeiro da et al. Red blood cell and leukocyte alloimmunization in patients awaiting kidney transplantation. Rev. Bras. Hematol. Hemoter. [online]. 2013, vol.35, n.3, pp.185-188. ISSN 1516-8484.


To determine the rates of red blood cell and leukocyte alloimmunization in patients with chronic kidney disease awaiting kidney transplantation.


In this cross-sectional and prospective study, the serum of 393 chronic kidney disease patients on a transplant waiting list in Ceará, Northeastern Brazil were tested for red cell and leukocyte antibodies. In addition, demographic, clinical and laboratory data were collected.


The average age in the sample of 393 patients was 34.1 ± 14 years. Slightly more than half (208; 52.9%) were male. The average numbers of transfusions and gestations were 3.1 ± 3.3 and 1.6 ± 6, respectively. One third (33.6%) were alloimmunized: 78% with leukocyte antibodies, 9.1% with red cell antibodies and 12.9% with both. Red cell antibodies were detected in 29 cases (7.4%), 17 of whom were women, who had received more transfusions than the males (p-value < 0.0001). The most frequently detected red cell antibodies belonged to the Rh (24.1%) and Kell (13.8%) blood group systems. Leukocyte antibodies were detected in 30.5% of cases, 83 of whom were women, who had received more transfusions than the males (p-value < 0.0001) and were more reactive to panel reactive antibodies (p-value < 0.0001). The mean alloreactivity to panel reactive antibodies was 47.7 ± 31.2%.


Chronic kidney disease patients on the transplant waiting list in Ceará, Brazil, display high rates of red cell (7.4%) and leukocyte (30.5%) alloimmunization. In this sample, alloimmunization was significantly associated with the number of transfusions and gender.

Keywords : Kidney failure, chronic; Blood transfusion; Kidney transplantation; Antibodies; Erythrocyte transfusion; Cross-sectional studies.

        · text in English     · English ( pdf )