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Brazilian Archives of Biology and Technology

Print version ISSN 1516-8913On-line version ISSN 1678-4324


PARAIBA, Lourival Costa; CASTRO, Vera Lúcia Scherholz Salgado de  and  MAIA, Aline de Holanda Nunes. Insecticide distribution model in human tissues viewing worker's health monitoring programs. Braz. arch. biol. technol. [online]. 2009, vol.52, n.4, pp.875-881. ISSN 1678-4324.

This work aimed at evaluating the characteristics of thirty nine insecticides on tissue distribution and accumulation, using their physico-chemical characteristics and the tissues lipid contents to calculate the compounds distribution among the tissues. The insecticides evaluated were selected among those registered in Brazil for agriculture use. The level I fugacity model was used for the calculations of insecticide distribution among the tissues of muscles, viscera, skin, fat, blood, liver, kidneys and gut. The octanol-water partition coefficient, water solubility and tissue lipid contents showed an insecticide distribution in human tissues. Cluster analysis was performed aiming the identification and separation of insecticides groups based on their physico-chemical characteristics as compounds with similar distribution within tissues and at the same time tissues with similar distribution of various insecticides. Cluster analysis pointed out three insecticide groups: in the first, 70 - 86% of insecticide accumulation was found in lipid tissues; in the second, 44 - 58%; and in the third, 9 -19%. These results could contribute to health monitoring programs of farmworkers.

Keywords : Fugacity model; Insecticide tissue distribution; Farmworkers; Health monitoring programs.

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