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Brazilian Journal of Microbiology

Print version ISSN 1517-8382


SA, Marcus Mandolesi et al. Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction. Braz. J. Microbiol. [online]. 2014, vol.45, n.3, pp.807-812. ISSN 1517-8382.

Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.

Keywords : antimicrobial; allylic thiocyanate; Morita-Baylis-Hillman reaction; MRSA.

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