SciELO - Scientific Electronic Library Online

vol.50 issue3Mucins and NCAM (CD56) in intrahepatic cholangiocarcinogenesisSolitary fibrous tumor of the larynx: report of two new cases author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Jornal Brasileiro de Patologia e Medicina Laboratorial

Print version ISSN 1676-2444


BALDIN, Rosimeri Kuhl Svoboda et al. Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?. J. Bras. Patol. Med. Lab. [online]. 2014, vol.50, n.3, pp.221-228. ISSN 1676-2444.


Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity.


Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis.

Materials and methods:

43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system.

Results and discussion:

The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively.


The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index.

Keywords : ulcerative rectocolitis; Crohn's disease; biopsy; pathology.

        · abstract in Portuguese     · text in English     · English ( pdf )