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Journal of Epilepsy and Clinical Neurophysiology

Print version ISSN 1676-2649

Abstract

PEREIRA, Alessandra; PEGORARO, Luiz Fernando Longuim  and  CENDES, Fernando. Autism and epilepsy: models and mechanisms. J. epilepsy clin. neurophysiol. [online]. 2012, vol.18, n.3, pp.92-96. ISSN 1676-2649.  https://doi.org/10.1590/S1676-26492012000300005.

Autism is associated with epilepsy in early childhood in almost 30% of children with either disorder, with evidence suggesting the same neurophysiopathology. The common mechanism in both diseases is not well defined and the heterogeneity of clinical symptoms in children with autism spectrum disorder (ASD) and epilepsy highlights the importance of a comprehensive assessment that includes investigation of underlying biological etiologies through neuroimaging, inflammatory, genetic and neurochemistry studies. Here, we review the main aspects of this association between autism and epilepsy.

Keywords : autism; epilepsy; neurobiology; neuroinflammation.

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