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Journal of Venomous Animals and Toxins including Tropical Diseases

On-line version ISSN 1678-9199

Abstract

ROZAS, E.  and  FREITAS, J. C.. Anti-inflammatory activity of the apolar extract from the seaweed Galaxaura marginata (Rhodophyta, Nemaliales). J. Venom. Anim. Toxins incl. Trop. Dis [online]. 2007, vol.13, n.2, pp.544-548. ISSN 1678-9199.  http://dx.doi.org/10.1590/S1678-91992007000200011.

The red seaweed Galaxaura marginata (Ellis & Solander) Lamouroux, well known by the antibacterial activity of its polar extract and the cytotoxic activity of its oxygenated desmosterol, showed anti-inflammatory action in its apolar fraction. Topical anti-inflammatory activity was observed in samples collected at São Sebastião channel, northern littoral of São Paulo State, Brazil. The apolar extract and its fractions obtained through Thin-Layer Chromatography (TLC) reduced the topical inflammation produced by croton oil in mouse ear. Such data indicated that the apolar extract from the marine red alga G. marginata displayed anti-inflammatory activity (since 1mg/ear extract reduced 95±0.5% inflammation), which could be the result of the synergic activity of the four fractions present in the apolar extract.

Keywords : seaweed; Galaxaura marginata; inflammation; Croton oil; edema; anti-inflammatory agents.

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