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Einstein (São Paulo)

Print version ISSN 1679-4508On-line version ISSN 2317-6385


NASCIMENTO, Claudia Mac Donald Bley et al. Consensus on the investigation of thrombophilia in women and clinical management. Einstein (São Paulo) [online]. 2019, vol.17, n.3, eAE4510.  Epub Aug 19, 2019. ISSN 2317-6385.


To standardize the investigation and clinical management of women with laboratory and/or clinical abnormalities suggestive of thrombophilia, in order to optimize antithrombotic approach and indication of laboratory tests.


A discussion was carried out among 107 physicians (gynecologists/obstetricians, hematologists and vascular surgeons) present at a forum held at the Hospital Israelita Albert Einstein, in São Paulo (SP), Brazil. As a minimum criterion, 80% agreement was established in the voting to each recommendation of conduct in the final document. The cases in which there was agreement below 80% were discussed again, reaching a consensual agreement of conduct for the document writing.


The standardization of an institutional consensus of suggestions of clinical approach contributes to a better management of the group to be evaluated and minimizes risks of intercurrent events. This was the first national consensus on the investigation of thrombophilia in women.

Keywords : Thrombophilia; Antiphospholipid syndrome; Venous thromboembolism; Pregnancy; Abortion, habitual; Pregnancy complications; Contraception; Venous thrombosis.

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