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Brazilian Oral Research

Print version ISSN 1806-8324On-line version ISSN 1807-3107

Abstract

MENEZES, Natascha Giovannetti de  and  COLOMBO, Ana Paula Vieira. Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. Braz. oral res. [online]. 2008, vol.22, n.4, pp.322-327. ISSN 1807-3107.  http://dx.doi.org/10.1590/S1806-83242008000400007.

This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ2 and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ2 = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ2 = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.

Keywords : TNF-alpha; Periodontal diseases; Genetic polymorphism; PCR.

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