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Brazilian Journal of Otorhinolaryngology

Print version ISSN 1808-8694


OLIVEIRA, Andreia Ardevino de et al. Persistence of the otoprotective effect: how long does otoprotection against amikacin lasts?. Braz. j. otorhinolaryngol. [online]. 2012, vol.78, n.6, pp.47-50. ISSN 1808-8694.

There is evidence that a "resistance phenomenon" occurs when a none-damaging dose of amikacin protects the hair cells from ototoxicity. Our goal is to prove that this resistance is persistent. METHOD: Experimental study - 14 albino guinea pigs (Cavia porcellus) divided into three groups. The auditory function was assessed by distortion product otoacoustic emissions (DPOAE): before exposure to amikacin, on the 15th day after the non-damaging dose was injected, at the end of the damage dose injection and prior to decapitation. RESULTS: Group A (control) presented normal hearing and histological pattern. Group B (amikacin 20mg/kg/day (IM) for 30 days and affecting dose (400 mg / kg / day) for 12 days and Group C (same protocol of Group B, but kept for 60 days and slaughtered), the DPOAE confirmed normal auditory function in the pre-exposure and maintenance of the standard-dose; however, significant loss of auditory function after the end of the damaging dose injection. CONCLUSION: The protection phenomenon did not extended for a period of 30 to 60 days after the application of damaging doses of amykacin.

Keywords : amikacin; aminoglycosides; drug toxicity; hair cells; auditory; inner; hair cells; auditory; outer.

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