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Revista Brasileira de Geriatria e Gerontologia

versão impressa ISSN 1809-9823

Resumo

ANTONINI, Tiago et al. Association study among physical activity level, cardiovascular risk and the apolipoprotein e polymorphism in elderly. Rev. bras. geriatr. gerontol. [online]. 2011, vol.14, n.1, pp.27-37. ISSN 1809-9823.  https://doi.org/10.1590/S1809-98232011000100004.

INTRODUCTION: With aging, there is gradual loss of muscle mass volume, accounting for almost all the loss of strength in the elderly. Studies have shown that physical activity can reduce morbidity from cardiovascular disease, stroke and increase the autonomy and independence. OBJECTIVE: To examine the association among levels of physical activity, cardiovascular risk and gene polymorphism of E Apolipoprotein in the elderly. METHODS: retrospective study, from an observational database on a population that selected sedentary seniors with a history of regular physical activity, carriers and noncarriers of the e4 allele of the gene of E Apolipoprotein. We applied the following questionnaires: (a) International Physical Activity Questionnaire (IPAC), (b) 24-hour recall and mini-food frequency questionnaire, (c) biochemical analysis of lipids and glucose levels. RESULTS: 255 elderly were investigated. Of these, 51 (20%) were men and 204 women (80%); 5.9 years of age (minimum 60 maximum 86±). The average age of the sample was 67.8 years). The frequency of alleles was: e3 allele = 0.78, e4 = 0.16 and e2 = 0.06; 45 elderly (17.6%) had at least one e4 allele and were sedentary, 31 (12.2%) had at least one e4 allele and had regular physical activity (active), 50 (19.6%) were classified as having other alleles of the apoE (E2/E3) and active while 129 (60.6%) were E2/E3 and sedentary. CONCLUSION: The physical activity could be an important factor in mitigating the negative genetic effects associated with the e4 allele of the polymorphism of apoE.

Palavras-chave : Aging; Elderlies; Physical Activity; Genetics Polymorphisms; Apo E; Cardiovascular Risk.

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