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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Abstract

BALTHAZAR, Márcio Luiz Figueredo; CENDES, Fernando  and  DAMASCENO, Benito Pereira. Category verbal fluency performance may be impaired in amnestic mild cognitive impairment. Dement. neuropsychol. [online]. 2007, vol.1, n.2, pp.161-165. ISSN 1980-5764.  https://doi.org/10.1590/s1980-57642008dn10200008.

To study category verbal fluency (VF) for animals in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer disease (AD) and normal controls.

Method:

Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, while aMCI was based on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent testing of category VF for animals, lexical semantic function (Boston Naming-BNT, CAMCOG Similarities item), WAIS-R forward and backward digit span, Rey Auditory Verbal Learning (RAVLT), Mini-Mental Status Examination (MMSE), and other task relevant functions such as visual perception, attention, and mood state (with Cornell Scale for Depression in Dementia). Data analysis used ANOVA and a post-hoc Tukey test for intergroup comparisons, and Pearson's coefficient for correlations of memory and FV tests with other task relevant functions (statistical significance level was p<0.05).

Results:

aMCI patients had lower performance than controls on category VF for animals and on the backward digit span subtest of WAIS-R but higher scores compared with mild AD patients. Mild AD patients scored significantly worse than aMCI and controls across all tests.

Conclusion:

aMCI patients may have poor performance in some non-memory tests, specifically category VF for animals in our study, where this could be attributable to the influence of working memory.

Keywords : verbal fluency; mild cognitive impairment; Alzheimer disease; neuropsychological tests..

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