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Dementia & Neuropsychologia

Print version ISSN 1980-5764On-line version ISSN 1980-5764


MATIOLI, Maria Niures Pimentel dos Santos et al. Association between diabetes and causes of dementia: Evidence from a clinicopathological study. Dement. neuropsychol. [online]. 2017, vol.11, n.4, pp.406-412. ISSN 1980-5764.


Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia.


To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study.


Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Diagnosis of diabetes was reported by the deceased's next-of-kin. Clinical dementia was established when CDR ≥ 1 and IQCODE > 3.41. Dementia etiology was determined by neuropathological examination using immunohistochemistry. The association of diabetes with odds of dementia was investigated using multivariate logistic regression.


We included 1,037 subjects and diabetes was present in 279 participants (27%). The prevalence of dementia diagnosis was similar in diabetics (29%) and non-diabetics (27%). We found no association between diabetes and dementia (OR = 1.22; 95%CI = 0.81-1.82; p = 0.34) on the multivariate analysis. AD was the main cause of dementia in both groups, while VaD was the second-most-frequent cause in diabetics. Other mixed dementia was the second-most-common cause of dementia and more frequent among non-diabetics (p = 0.03).


Diabetes was not associated with dementia in this large clinicopathological study.

Keywords : Alzheimer's disease; Diabetes mellitus; vascular dementia; neuropathology; clinicopathologic study.

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