SciELO - Scientific Electronic Library Online

vol.49 issue2Evaluation of the protective effects of tocotrienol-rich fraction from palm oil on the dentate gyrus following chronic restraint stress in rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


ROQUE, Fátima; RAMA, Ana Cristina; SOUSA, João José  and  PINA, Maria Eugénia. Development and stability assessment of liquid paediatric formulations containing sildenafil citrate. Braz. J. Pharm. Sci. [online]. 2013, vol.49, n.2, pp.381-388. ISSN 2175-9790.

The purpose of this study is to develop and improve oral liquids formulations of sildenafil citrate for paediatric use. Four different formulations were developed, which are as follows: two aqueous solutions of sildenafil citrate (2.5 mg/mL), with or without preservatives, and two other solutions of sildenafil in simple syrup (1.25 mg/mL), with or without preservatives. All of the formulations were physically, chemically and microbiologically stable for three months. The results of the stability studies allowed for the optimisation of formulations without preservatives due to their simplicity and their similar stable conditions when compared to the formulations containing antimicrobials. The shelf life of both formulations was three months; however, upon opening, aqueous solutions should be used within 10 days and kept refrigerated, and syrup solutions should be used within 14 days in a hospital setting.

Keywords : Chemical stability; Microbiological stability; Sildenafil citrate; Paediatric formulations.

        · abstract in Portuguese     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License