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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487

Arq Bras Endocrinol Metab vol.58 no.1 São Paulo Feb. 2014 

Cartas ao Editor

Evaluation of thyroid function and autoimmunity in HIV-infected women

Avaliação da função tireoidiana e autoimunidade em mulheres infectadas pelo HIV

Leiliane Gonçalves de Carvalho1 

Patrícia de Fátima dos Santos Teixeira1  2 

Ana Luiza Brandão Galotti Panico1 

Marcela Vaisberg Cohen1 

Maria Fernanda Miguens Castelar Pinheiro3 

Paulo Feijó Barroso1  4 

Mário Vaisman1  2 

1Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

2Hospital Universitário Clementino Fraga Filho (HUCFF), UFRJ, Endocrinologia, Rio de Janeiro, RJ, Brazil

3Sérgio Franco Medicina Diagnóstica, Rio de Janeiro, RJ, Brazil

4HUCFF/UFRJ, Doenças Infecto-Parasitárias (DIP), Rio de Janeiro, RJ, Brazil

Although we appreciated your comments, we really did not find a statistically significant relationship between the presence of autoantibodies (autoimmune disease) in patients infected by HIV in use of HAART ( 1 ).

It is worthwhile remembering that there are many autoantibodies (“anti-cardiolipin, anti-beta2 GPI, anti-DNA, anti-small nuclear ribonucleoproteins (snRNP), anti-thyroglobulin, anti-thyroid peroxidase, anti-myosin, and anti-erythropoietin antibodies”) that may be seen in patients with HIV infection, and there are some mechanisms to explain that, but the relation with the use of HAART has not been demonstrated ( 2 - 4 ).

There are some cases reported of Graves’ disease in patients with HIV infection, but the relationship with the use of HAART was not demonstrated ( 3 , 5 ).

We are thankful for your observations, though, as it is very important to have opinions about the same subject.


. Carvalho LG, Teixeira PF, Panico AL, Cohen MV, Pinheiro MF, Barroso PF, et al. Evaluation of thyroid function and autoimmunity in HIV-infected women. Arq Bras Endocrinol Metabol. 2013;57(6):450-6. [ Links ]

. Zandman-Goddard G, Shoenfeld Y. HIV and autoimmunity. Autoimmun Rev. 2002;1(6):329-37. [ Links ]

. Sheikh V, Dersimonian R, Richterman AG, Porter BO, Natarajan V, Burbelo PD, et al. Graves’ disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4+ T-cell recovery. AIDS. 2014;28(1):31-9. [ Links ]

. Chen F, Day SL, Metcalfe RA, Sethi G, Kapembwa MS, Brook MG, et al. Characteristics of autoimmune thyroid disease occurring as a late complication of immune reconstitution in patients with advanced human immunodeficiency virus (HIV) disease. Medicine (Baltimore). 2005;84:98-106. [ Links ]

. Crum NF, Ganesan A, Johns ST, Wallace MR. Graves’ disease: an increasingly recognized immune reconstitution syndrome. AIDS. 2006;20(3):466-9. [ Links ]

Received: December 27, 2013; Accepted: January 9, 2014

Correspondence to : Leiliane Gonçalves Carvalho

Disclosure: no potential conflict of interest relevant to this article was reported.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.