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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.24 no.1 São Paulo Mar. 1966 

Metabolism of fat in subacute combined degeneration of the spinal cord


Metabolismo dos lípides na mielose funicular



Horacio M. CanelasI; Nelson de CarvalhoII; Arnaldo Gama da RochaI

IDepartment of Neurology and the Center of Nuclear Medicine
IIUniversity of São Paulo School of Medicine, Brazil




In 10 cases of subacute combined degeneration of the spinal cord the absorption, clearance and utilization of labeled fat was studied. In 4 cases disorders of the lipid metabolism were found.
Although not significantly, the peripheral and dorsal funiculi syndromes were more severe in the 4 cases with impaired fat metabolism than in the normal cases, while the pyramidal syndrome was almost the same in the two groups. The whole neurological picture was also more severe in the 4 cases with disorders of fat metabolism.
These results seem to indicate that the impairment of lipid metabolism evidenced in such cases bears no direct relationship with the demyelinating process in general, and would rather attend a deficiency of metabolites (probably B-complex vitamins) other than vitamin B12, which play a more significant role in the preservation of the peripheral nerves.


Em 10 casos de mielose funicular foram estudadas a absorção, a depuração e a utilização de lípides radioativos. Em 4 dêsses casos foram verificadas alterações do metabolismo lipídico.
Embora não significantemente, as síndromes periférica e funicular dorsal mostraram-se mais intensas nos 4 casos com distúrbios do metabolismo lipídico que nos demais, enquanto a síndrome piramidal foi aproximadamente semelhante nos dois grupos de pacientes. A sintomatologia neurológica global também se apresentou mais intensa nos 4 casos com alterações do metabolismo lipídico.
Estes resultados parecem indicar que as alterações do metabolismo das gorduras demonstradas nesses casos não se vinculam diretamente ao processo desmielinizante em geral, parecendo antes refletir uma carência de metabólitos (provavelmente vitaminas do complexo B) diversos da vitamina B12, que desempenhariam papel mais importante na preservação dos nervos periféricos.



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Read at the First International Symposium on Nuclear Biology and Medicine, held in São Paulo, Brazil, September 20-25, 1964.
Department of Neurology - University of São Paulo School of Medicine - Caixa Postal 3461 - São Paulo, SP - Brasil

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