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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.33 no.1 São Paulo Mar. 1975 

Studies of the thyroid function in children with Down's syndrome


Estudos da função tireóidea em crianças com síndrome de Down



Benjamin J. SchmidtI; Nelson CarvalhoII; Cláudio C. OrtegaIII; José LibermamIII; Jane M. M. BiazziIII; Pojucan M. TapajósIII; Stanislau KrynskiIV

IProfessor Adjunto do Departamento de Pediatria da EPM (Serviço Prof. A. A. Carvalho)
IIDiretor Clínico do Centro de Medicina Nuclear da FMUSP
IIIMédicos do Centro de Habilitação de São Paulo
IVDiretor Técnico do Centro de Habilitação de São Paulo




The thyroid function (T-3 triiodothyronine; T-4 tetraiodothyronine and the captation of the I131 through the thyroid, in 2 and 24 hours after the intake of isotope radium), was studied in patients with Down's syndrome and the results being compared to those obtained from the respective siblings, all clinically normal. The comparative results showed no significant differences, except in the 2 hours captation of the I131 through the thyroid (P < 0.01). The findings suggest that the hypothalamus-hypophysary or the response of the thyroid gland would be slow, but compensated when analyzed after 24 hours.


Os autores estudaram a função tireóidea (T-3, triiodotironina; T-4, tetraiodotironina e captação do I131 pela tireóide com 2 e 24 horas após a ingestão do radioisótopo) em pacientes com síndrome de Down, e compararam os resultados com os obtidos nos seus respectivos irmãos, todos clinicamente normais. Os resultados comparativos não apresentaram diferenças significativas, exceto na captação de 2 horas do I131 pela tireóide (P < 0,01). Os achados sugerem que o estímulo hipotálamo hipofisário ou a resposta da glândula tireóide seria lento (a) mas compensado (a) quando analisados após 24 horas.



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1. BENDA, C. E. & BIXBY, E. M. — Function of the thyroid and pituitary in mongolism. Am. J. Dis. Child. 58:1240, 1939.         [ Links ]

2. BENDA, C. E.; DAYTON, N. A. & PROUTY, R. A. — On the etiology and prevention of mongolism. Am. J. Psychiat. 99:822, 1943.         [ Links ]

3. BENDA, C. E. — Mongolism and Cretinism. 2nd ed. Grune and Stratton, New York, 1949.         [ Links ]

4. BENDA, C. E. — What is mongolism? Internat. Rec. Med. 165:75, 1952.         [ Links ]

5. BRAVERMAN, L. E.; VAGENAKIS, A. G.; FOSTER, A. E. & INGBAR, S. H. — Evaluation of a simplified technique for the specific measurement of serum thyroxine concentration. J. Clin. Endocrinol. 32:497, 1971.         [ Links ]

6. BROOKEMAN, V. A. & WILLIAMS, C. M. — Evaluation of the resin strip technique for determing serum T-3 binding capacity and thyroxine. J. Nucl. Med. 12:55-59, 1971.         [ Links ]

7. COTTINO, F.; FERRARIS, G. M. & CODA, G. — Thyroidal function in mongolism. J. Clin. End. Metab. 16:830, 1956.         [ Links ]

8. International Agency Atomic Energy (Wien) — Nov.: 20-30, 1960.         [ Links ]

9. JACKIM, F.; WORTIS, J. & ADESMAN, J. — Triiodothyronine uptake by erythrocytes in mongolism. Proc. Soc. Exp. Biol. Med. 107:401, 1961.         [ Links ]

10. KEARNS, J. F. & HUTSON, W. F. — The use of radio activeoidine studies in congenital thyroid aplasia. Quart. Bull. Northwestern Med. School 25:270, 1951.         [ Links ]

11. KURLAND, G. S.; FISHMAN, J.; HAMOLSKY, M. W. & FREEDBERG, A. S. — Radioisotope study of thyroid function in 21 mongoloid subjects, including observations in 7 parents. J. Clin. Endocrinol. 17:552, 1957.         [ Links ]

12. MYERS, C. R. — An application of the control group method to the problem of the etiology of mongolism. Proc. Am. A. Ment. Deficiency 62:142, 1938.         [ Links ]

13. PEARSE, J. J.; REISS, M. & SUWALSKI, R. T. — Thyroid functions in patients with mongolism. J. Clin. Endochinol. 23:311, 1963.         [ Links ]

14. RIMOIN, D. L. — Thyroxine-binding proteins in mongolism. J. Clin. End. Metab. 25:708, 1965.         [ Links ]

15. SAXENA, K. M. & PRYLES, C. V. — Thyroid function in mongolism. J. Pediatrics 67:363, 1965.         [ Links ]

16. SIMON, A.; LUDWIG, C; GOFMAN, J. W. & CROOK, G. H. — Metabolic studies in mongolism. Am. j. Psychiat. 111:139, 1954.         [ Links ]

17. SPINELLI-RESSI, F. & BERGONZI, F. — Red cell triiodothyronine uptake as a measure of thyroid function in mongolism. Acta Paediat (Stokolm) 52:575, 1963.         [ Links ]



Departamento de Pediatria — Escola Paulista de Melicina — Rua Botucatu 720 — 04203 São Paulo, SP — Brasil.
Trabalho apresentado no XVIII Congresso Brasileiro de Pediatria (Salvador, BA, de 13-10-1973), realizado no Centro de Habilitação de São Paulo, em colaboração com a Escola Paulista de Medicina (EPM) e o Centro de Medicina Nuclear da Faculdade de Medicina da Universidade de São Paulo (FMUSP), sob auxílio da Comissão Nacional de Energia Nuclear (São Paulo)

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