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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.49 no.4 São Paulo Dec. 1991

http://dx.doi.org/10.1590/S0004-282X1991000400008 

CONTENTS CONTEÚDO

 

Biochemical correlate of depression in children

 

Correlatos bioquímicos da depressão em crianças.

 

 

E.A. QueirozI, II; A. B. Lombardi II, III; C.R.H. Santos FurtadoII; C. C. D. PeixotoII; T. A. SoaresII; Z. L.FabreII; J. C. BasquesIV; M. L. M. FernandesV; J. R. S. LippiVI

IDepartment of Pharmacology of ICB; Research Center, Neuropsyciatry Laboratory, Medicine School, Federal University of Minas Gerais (UFMG)
IIStudent, Interdisciplinary Course of Specialization in Children and Adolescence Psychology and Psychiatry (CIEPSIA)
IIIDepartment of Pediatrics, Medicine School, UFMG
IVLaboratory Doctor
VDepartment of Statistics, ICEx, UFMG
VIDepartment of Psychiatry, Medicine School, UFMG; CIEPSIA and research coordinator. CNPq grant 40.5437/84.

 

 


SUMMARY

The degree of depression in 88 abandoned children was analysed through a depression rating scale adapted to prepubertal children. The items were grouped into three dimensions: sociological-relational, psychological and biological. In 46 children from this sample it was dosed plasmatic Cortisol and the urinary excretion of catecholamine, VMA, HVA and 5-HIAA. When analysing the principal components, the sociological and psychological dimensions were the most important ones in the sample, followed by age and catecholamine variables. The group of male depressed children presented a higher level of catecholamine urinary excretion and a lower peak of plasmatic Cortisol than the non-depressed group. The variable age, in both sexes, was correlated with the biochemical variable catecholamine. Biochemical alterations are present in depressed children but it is difficult to show a correlation of dependence between them and the phenomenological aspects of depression.


RESUMO

O grau de depressão em 88 crianças abandonadas foi analisado por escala de avaliação de depressão adaptada para crianças na pré-puberdade. Os itens da escala foram agrupados em três dimensões: sociológico-relacional, psicológica e biológica. Em 46 crianças desta amostra foram dosados o Cortisol plasmático e a excreção urinária de. catecolamina, VMA, HVA e 5-HIAA. Pela análise dos principais componentes, mostraram-se mais importantes, na amostra, as dimensões sociológica e psicológica, seguidas dos componentes idade e catecolamina. O grupo de crianças do sexo masculino com depressão apresentava maior nível de excreção urinária de catecolamina e menor pico de Cortisol plasmático que o grupo sem depressão. A variável idade, em ambos os sexos, correlacionava-se à variável catecolamina. Alterações bioquímicas estão presentes em crianças com depressão, mas é difícil demonstrar correlação de dependência entre elas e aspectos fenomenológicos da depressão.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Acknowledgements - We would like to thank Mrs Vera Lucia Roberto and Mrs lone Batista Gomes for their technical assistance.

 

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Dr. Eduardo Antonio de Queiroz - Faculdade de Medicina, UFMG - Caixa Postal 340 - 30130 Belo Horizonte MG - Brasil.

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