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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.2 São Paulo June 1995 

Miastenia gravis. resultados de timectomia em 52 pacientes


Myasthenia gravis: results of thymectomy in 52 patients



José Teotonio de Oliveira; Gilberto Belisário Campos; Francisco Eduardo C. Cardoso

Serviço de Neurologia do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG)




Durante o período de 1971 a 1993, 52 miastênicos sem timoma (7 homens e 45 mulheres ) foram timectomizados por via esternal. Os resultados foram classificados em remissão e não-remissão . A taxa de remissão foi 48%. No grupo de remissões havia 5 homens e 20 mulheres. O tempo de seguimento foi de 5,5 anos em ambos os grupos. Os pacientes foram classificados clinicamente segundo a classificação de Osserman. De 16 pacientes na categoria II A, 11 entraram em remissão; de 36 pacientes nas categorias II B e III, 14 entraram em remissão. O tempo de duração de doença foi de 1,8 e 4,3 anos nos grupos de remissões e não-remissões, respectivamente. Todos os pacientes que entraram em remissão tinham menos de quatro anos de doença. Dos 43 pacientes com menos de quatro anos de doença, 42% não apresentaram remissão significando que um tempo de doença de menos de quatro anos não é indicador de remissão. Nossos dados indicam um melhor prognóstico quando a timectomia é feita nos primeiros quatro anos de doença.

Palavras-chave : miastenia gravis, timectomia


From 1971 to 1993, 52 myasthenics without thymomas ( 7 men and 45 women) were thymectomized.The results were categorized in remissions and non-remissions. The remission rate was 48%. In the remission group there were 5 men and 20 women and in the non-remission group 2 men and 25 women.The follow-up time was 5.5 years in both groups. There were 16 patients in Osserman category II A , 11 achieving remission; 36 patients were in categories IIB and III, and 14 achieved remission. The duration of disease was 1.8 years and 4.3 years in the remission and non-remission groups, respectively. All patients with remission had less than four years of disease but among the 43 patients with less than four years of symptoms, 42% did not achieve remission. Our data reinforce the need for early thymectomy in myasthenia gravis.

Key words:myasthenia gravis, thymectomy



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Os nossos agradecimentos ao Dr. José Sílvio Rezende pela realização da maioria das timectomias.



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Aceite: 18 - outubro - 1994.



Dr. José Teotonio de Oliveira - Av. Getúlio Vargas, 67 - 30112-020 Belo Horizonte MG - Brasil.

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