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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.29 no.2 São Paulo Mar./Apr. 1987 



Cell mediated immune response in human antirabies revaccination


Resposta imune mediada por células na re-vacinação anti-rábica humana



Débora Regina Veiga; Carlos Roberto Zanetti; Nelson Figueiredo Mendes; Octávio Augusto de Carvalho Pereira

From the "Disciplina de Imunologia da Escola Paulista de Medicina", São Paulo - Brasil

Address for reprints




The occurrence of secondary cell mediated immune response (CMI) in human antirabies immunization was studied.
The Puenzalida & Palácios vaccine was used because it is routinely used in Brazil.
CMI was evaluated by lymphoblastic transformation indices obtained in whole blood culture in the presence of rabies and control (nervous tissue) antigens.
Eleven volunteers submitted to revaccination constituted the group under study, while three other volunteers submitted primo vaccination were utilized as control group.
A clear secondary CMI to rabies antigen was detected in all the revaccinated volunteers who showed earlier and more intense response than the control group.
Response to the control antigen, however, present in all the components of the first group was not detectable in two out of the three primovaccinated and very low in the third one.

Key words: Human antirabies revaccination; Cellular immunity in rabies; Anti-rabies immune response


Foi estudada a ocorrência de resposta imune celular na re imunização anti-rábica humana.
Usou-se a vacina Fuenzalida & Palácios a qual é rotineiramente usada no Brasil.
A resposta imune celular foi avaliada pelo índice de transformação blástica obtido em cultura de sangue total, na presença de antígeno rábico e antígeno controle (sistema nervoso) .
O grupo em estudo constitui se de 11 voluntários submetido a re vacinação, enquanto três outros, submetidos a primo-vacinação foram utilizados como grupo controle.
Detectou-se uma clara resposta imune celular secundária contra antígeno rábico em todos os voluntários revacinados, cujas respostas foram mais rápidas e mais intensas do que as do grupo controle.
Observou-se também, resposta ao antígeno controle em todos os indivíduos do grupo de revacinados. No grupo de primovacinados, resposta ao antígeno controle foi fracamente observada em somente um indivíduo.



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The authors express their gratitude to the "Instituto Butantan". São Paulo for providing antirabies vaccines. This work was supportedt by CNPq, CAPES and FINEP.



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Address for reprints:
Octávio Augusto de Carvalho Pereira
M.D. Escola Paulista de Medicina
Rua Botucatu, 862 - 4.° andar
CEP. 04023 - São Paulo - Brasil.

Recebido paraa publicação em 16/9/86.

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