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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.33 no.4 São Paulo July/Aug. 1991 



Antibody to human T-lymphotropic virus in a patient with Guillain-Barré syndrome (case report)


Anticorpo para o vírus linfotrópico humano T em um paciente com a síndrome de Guillain-Barré



C.M. NakauchiI; A.C. LinharesI; M.L.C. GomesI; K. MaruyamaII; L.I. KanzakiIII; V.N. AzevedoIII

ISeção de Vírus do Instituto Evandro Chagas, Fundação Nacional de Saúde. Belém, Pará, Brazil
IIDepartment of Pathology. Chiba Cancer Center Research Institute, Chiba, Japan
IIIDisciplina de Virologia, Departamento de Patologia, Universidade Federal do Pará. Belém, Pará, Brazil

Address for correspondence




Serum sample obtained from a male, 12 year old patient suffering from Guillain-Barré syndrome (GBS) was positive for human T-lymphotropic virus (HTLV-I) antibody by the enzyme-linked immunosorbent assay (ELISA) and the Western Blot analysis (WB). Attempts to isolate enteroviruses (including poliovirus) from faecal material in both tissue culture and suckling mice were unsuccessful; in addition, acute and convalescent paired serum samples did not show any evidence of recent poliovirus infection when tested against the three serotypes. Specific tests for detection of Epstein-Barr virus infection were not performed; however, the Paul-Bunnel test yielded negative results. ELISA for detection of anti-cytomegalovirus IgM was also negative. The concomitant occurrence of either adult T cell leukemia (ATL) or lymphoma was not recorded in this case.

Key words: HTLV-I; Antibody; Guillain-Barré syndrome


Amostra de soro obtida de paciente com a síndrome de Guillain-Barré revelou-se positiva quanto à presença de anticorpos para o vírus linfotrópico humano T (HTLV-I) pelo método imuno-enzimático (ELISA) e a análise por "Western-Blot". Resultaram negativos os testes visando à detecção de enterovírus (incluindo poliovírus) a partir de material fecal, tanto em cultura de tecidos como em camundongos recém-nascidos; exames com amostras de soro aguda e convalescente não exibiram qualquer evidência de infecção recente pelos três tipos de poliovírus. O teste de Paul-Bunnel, assim como o "ELISA" para a detecção de IgM anti-citomegalovírus resultaram negativos. Não foi registrada, no presente caso, quer a leucemia adulta de células T, quer linfomas.



Full text available only in PDF format.

Texto completo disponível apenas em PDF.




The technical advice provided by Ms. Cereja Kazuko Nakauchi, Mrs. Laura Nakauchi and Ms. Euda Galiza is gratefully acknowledged.



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Address for correspondence:
Dr. A.C. Linhares
Seção de Vírus, Instituto Evandro Chagas
Av. Almirante Barroso, 492
CEP 66.050 - Belém, Pará, Brasil

Recebido para publicação em 07/11/1990
Aceito para publicação em 15/01/1991

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