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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.35 no.3 São Paulo May/June 1993 



Effect of oxamniquine on cell adhesion to Schistosoma mansoni larvae in the peritoneal cavity of naive mice


Efeito da oxamniquina sobre a adesão celular da larva do S. mansoni na cavidade peritoneal de camundongos



Alan Lane de Melo; Leógenes Horácio PereiraI

IDepartamento de Parasitologia Instituto de Ciências Biológicas da UFMG, CP 2486, CEP 30161-970, Belo Horizonte, Minas Gerais, Brasil




The treatment of naive mice with high closes of oxamniquine, 1 hour before the intraperitoneal inoculation of Schistosoma mansoni cercariae, induces a delay in the transformation process resulting in a longer host cell adhesion.

Key words: Schistosoma mansoni; Cell adhesion; Cercaria; Schistosomulum; Oxamniquine.


O tratamento de camundongos sem infecção prévia com altas doses de oxamniquina, 1 hora antes do inóculo intraperitoneal com cercárias de Schistosoma mansoni, induz a um atraso no processo de transformação, resultando conseqüentemente em larvas com adesão celular mais duradoura.



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Recebido para publicação em 11/08/1992
Aceito para publicação em 06/10/1992
Supported by The Parasitic Diseases Programme - WHO, Switzerland, CNPq, FINEP, and FAPEMIG, Brazil.

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