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vol.82 suppl.4Localization of Schistosoma mansoni protective antigens by indirect immunofluorescenceStudy of the in vitro cell proliferation of lymphocytes from Manson's Schistosomiasis patients treated with praziquantel author indexsubject indexarticles search
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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.82  suppl.4 Rio de Janeiro  1987 

Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection

Somei Kojima1 

Tuenta Janecharut1 

Hidekazu Hata1 

Munetoshi Niimura1 

Chiba University, School of Medicine, Department of Parasitology, Chiba, Japan


We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.


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