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Adjustable inspiratory occlusion valve in experimental bronchopleural fistula. A new therapeutic perspective1 1 Research performed at Center for Experimental Medicine and Surgery, Faculty of Medical Sciences, Universidade de Campinas (UNICAMP), Brazil.

Abstract

PURPOSE:

To assess the efficacy of an adjustable inspiratory occlusion valve in experimental bronchopleural fistula during mechanical ventilation.

METHODS:

We studied six mechanically ventilated pigs in a surgically created, reproducible model of bronchopleural fistula managed with mechanical ventilation and water-sealed thoracic drainage. An adjustable inspiratory occlusion valve was placed between the thoracic drain and the endotracheal tube. Hemodynamic data, capnography and blood gases were recorded before and after the creation of the bronchopleural fistula as well as after every adjustment of the inspiratory occlusion valve.

RESULTS:

When compared with the standard water-sealed drainage treatment, the use of an adjustable inspiratory occlusion valve improved the alveolar tidal volume and reduced bronchopleural air leak (p<0.001), without hemodynamic compromise when compared with conventional water sealed drainage.

CONCLUSION:

The use of an adjustable inspiratory occlusion valve improved the alveolar tidal volume, reduced alveolar leak, in an experimental reproducible model of bronchopleural fistula, without causing any hemodynamic derangements when compared with conventional water sealed drainage.

Fistula; Respiration, Artificial; Capnography; Models, Animal; Swine


Introduction

A bronchopleural fistula (BPF) is a condition that has high mortality rate especially when associated with invasive mechanical ventilation (MV). It manifests initially by pneumothorax and, after the installation of adequate chest tube drainage, by air leakage from the airway to the outside11. Pierson DJ, Horton CA, Bates PW. Persistent bronchopleural air leak during mechanical ventilation. Chest. 1986;90(3):321-3. doi: 10.1378/chest.90.3.321.
https://doi.org/10.1378/chest.90.3.321...
. The diagnosis of BPF is established when air leak through the chest tube persists for at least 24 hours22. Bishop MJ, Benson MS, Sato P, Pierson DJ. Comparison of high-frequency jet ventilation with conventional mechanical ventilation for bronchopleural fistula. Anesth Analg. 1987;66:833-8. PMID: 3304022. , 33. Kempainen RR, Pierson DJ. Persistent Air leaks in patients receiving mechanical ventilation. Semin Respir Crit Care Med. 2001;22(6):675-84. PMID: 16088712..

The etiology of BPF is multifactorial and may result from pneumonia, radiotherapy, chemotherapy, tumors, tuberculosis, pulmonary resection surgery, chest trauma, ARDS and, in Intensive Care Units (ICUs), it is often associated with barotrauma and MV44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
, 55. Baumann M, Sahn S. Medical management and therapy of bronchopleural fistulas in the mechanically ventilated patient. Chest. 1990;97:721-8. PMID: 2407455.. Whatever the cause, BPF is difficult to treat, considering that the patients receive positive pressure, which tends to hinder closure of the fistula. Significant air leakage results in high morbidity and the mortality rate of 18% to 50%44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
, 66. Martins WR, Siefkin AP, Allen R. Closure of a bronchopleural fistula with bronchoscopic instillation of tetracycline. Chest. 1991;99:1040-2. PMID: 2009764..

Patients with BPF may significantly worsen the ventilation/perfusion balance and arterial blood gases. BPF causes well described changes such as leakage of gases, reduction of the airway pressure, reduced alveolar ventilation per minute, alveolar collapse, arterial hypoxemia, respiratory acidosis, barotrauma or volutrauma in the contralateral lung as a complication of MV, difficulty in maintaining the positive end-expiratory pressure (PEEP) and self-cycling44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
, 77. Spinale FG, Linker RW, Crawford FA, Reines HD. Conventional versus high frequency jet ventilation whit a bronchopleural fistula. J Surg Res. 1989;46(2):147-51. PMID: 2493107..

The success in handling BPF depends on treatment strategies, tailored according to individual needs of patients. The conventional treatment consists of organ support, intercostal catheters, chest drainage and MV and surgical or bronchoscopic definitive therapies44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
.

Since the '70s, various noninvasive methods have been used to solve or lessen the effects of positive pressure MV on BPF, most of them consisting of different methods of pressurizing the chest drainage flask. However, no controlled clinical study or trial has been documented.

The aim of this study was to describe a new adjustable inspiratory occlusion valve (aIOV) used to reduce the deleterious effects caused by BPF, acting directly on the air leakage, improving pulmonary ventilation and blood gases, but without causing hemodynamic derangements.

Methods

This study was approved by the Ethics Committee on Animal Experimentation of the Institute of Biology, Universidade de Campinas (Protocol nº 1685-1 A).

We used six large white pigs weighing 25kg each which, after general anesthesia, underwent endotracheal intubation (6mm), and mechanically ventilation. The endotracheal tube and the mechanical ventilator circuit were connected through the sensor of volumetric capnography (CO2SMO Plus DX-8100(r) Dixtal/Novametrix), which was calibrated before the beginning of each experiment. The software (APlusÒ) used to capture and store data online and offline enabled the measurement (in mL) of BPF output, which was calculated by subtracting the expired volume (Ve) from the inspired volume (Vi). The percentage of fistula output was defined as the result of this subtraction (Vi - Ve) divided by the Vi.

The respiratory rate, tidal volume and FIO2 in the MV remained the same throughout the experiment and was possible observed an increase in PaCO2 and slightly decrease in PaO2, but not statistically significant, probably resulting from alveolar hypoventilation.

A pulmonary artery catheter (PAC) was introduced through the femoral vein. Mean arterial pressure (MAP) was recorded continuously (Multiparameter Monitor Dixtal DX-2020; AJIBP-0). Data from arterial and venous blood gases and hemo-oximetry were collected before (baseline), after creation of BPF and after each experimental setting.

The animals received a continuous infusion of saline (0.9%) as well as anesthetics, sedatives and neuromuscular blockers as needed.

Surgical procedure

Through a left thoracotomy, a resection of the lingula was performed leaving the bronchial stump open in order to create a BPF with an output exceeding 50% of the inspired volume. The chest cavity was closed and drained into the water sealed system for initial observation of the high output BPF (Figure 1).

Figure 1.
Adjustable inspiratory occlusion valve (aIOV).

This device, called adjustable inspiratory occlusion valve (deposit number BR 10 2012 021143 2 and BR 13 2013 032098 5 patents), which must be connected to the outer extremity of the chest drain, consists of a nipple valve upon which a flexible diaphragm has been superimposed. The diaphragm is activated by proximal pressure (pressure generated in the respiratory system) via a flexible tube connected to the terminal "Y" of the patient (inspiratory pathway). Depending on the size of the nozzle and of the diaphragm, there is a 1:2 relationship between the proximal pressure and the closing pressure of the drain. That is, when the proximal pressure is 10cmH2O, the occlusion pressure in the drain is 20cmH2O. In order to allow finer adjustments in the occlusion pressure, we used a needle valve that allowed for a controlled escape flow. The larger the proximal escape flow, the lower the working pressure of the diaphragm. This way, we were able to perform appropriate adjustments in the release pressure of the chest drain, preventing unwanted pressurization of the pleural space. In short, this device is a pressure-stabilizing valve that keeps the pleural pressure slightly below the intrapulmonary pressure, reducing the fistula outflow and allowing for the controlled clearance of pleural air, thus preventing the creation of a tension pneumothorax. The pressure gradient is expected to be 2 to 3cmH2O (Figure 2).

Figure 2.
Experimental protocol of mechanical ventilation.

The MV protocol consisted of Volume Controlled Ventilation (VCV), with a Tidal Volume (VT) of 8ml/Kg, Fraction of Inspired Oxygen (FIO2) of 0.21, Inspiratory time versus Expiratory time (I:E ratio) = 1:2, Respiratory Rate (RR) of 22 bpm, Positive End Expiratory Pressure (PEEP) of 5 cmH2O. Using these ventilatory parameters, it was possible to maintain the end-tidal CO2(PetCO2) around 45mmHg.

Data from arterial blood gases were collected before (baseline), after creation of BPF and after each experimental treatment. A treatment was defined as a 10-minute period of ventilation with the adjustable inspiratory occlusion valve (aIOV) set in different aleatory positions of bronchopleural fistula output (BPFO) from highest to lowest rate of fistula. The treatment 0- corresponds to simple water-sealed drainage of the thorax. There were four treatments with the valve regulated, aleatorialy, in different percentages of BFPO: Treatment 1 (corresponding to 69.6±20.0% of BPFO); Treatment 2- corresponding to 61.0±19.5% of BPFO); Treatment-3 (corresponding to 16.8±10.1% of BPFO); Treatment 4 - valve in the closed position (corresponding to 9.7±6.2% of BPFO).

A statistical analysis was performed for comparison of the continuous variables Cardiac Output (CO), Bronchopleural fistula Output (BPFO), Mean Arterial Pressure (MAP), End Tidal CO2 (PetCO2), Arterial Partial Pressure of O2(PaO2), Arterial Partial Pressure of CO2 (PaCO2), Arterial Oxygen Saturation (SaO2), and Alveolar Tidal Volume (VT alv) between treatments that began with the water seal and progressed with the use of the valve until it was almost completed closed.

The statistical analysis was carried out comparing only treatments 0 to 4 using analysis of variance, considering each pig as an experimental block. Fixed the significance level at 5%, if the p-value is significant, then at least one pair of treatments has statistical different means. To check if there is difference between two treatments, a Tukey's honest difference test was performed.

Results

The results of changes in ventilation and hemodynamic recorded in pre-fistula (baseline) and after the creation of the BPF (treatments 0, 1, 2, 3 and 4) and the p-value correspondent to the ANOVA for comparison of the treatments 0 to 4 are arranged in Table 1.

Table 1.
Data of volumetric capnography, arterial blood gas and hemodynamic variables expressed as mean and standard deviation

The significant differences between two treatments by Tukey's test are represented by the same letters below their means. Fistula output: Treatment 0 when compared to treatments 1 and 2 resulted in statistically significant increase in the fistula output (Tukey, p=0.0001; p=0.0071, respectively), however the treatment 0 when compared to treatments 3 and 4 resulted in statistically significant decreased in the fistula output (Tukey, p=0.0003 and p<0.0001; respectively).

Arterial partial pressure of CO2: In treatments 1 to 4 there was observed greater values of PaCO2 when compared to treatment 0 (Tukey; p=0.0008; p=0.0002; p=0.0109 and p=0.0135, respectively).

Alveolar volume: Treatments 3 and 4 presented statistically greater values when compared to treatment 0 (Tukey; p=0.0083 and p=0.0004, respectively).

Arterial partial pressure of O2 and oxygen saturation: The values observed in treatments 1 to 4 are smaller than treatment 0, but not significant. (ANOVA for PaO2and Sat02 respectively: p=0.0836 and p=0.0992; Table 1).

Mean arterial pressure: There is no significant difference between treatments 0 to 4 (ANOVA p=0.3038; Table 1).

Cardiac output: There is a significant increase from treatment 0 to treatment 1 (Tukey, p=0.0472). However, there are no significant decreases between treatments 1 to 4 when compared to treatment 0.

The Figure 3 displays a representative model of volumetric capnography curves, during the respective treatments: water seal (0), 1, 2, 3 and 4. Note the significant improvement of the alveolar volume during the treatments.

Figure 3.
Representative figure of Volumetric Capnography during treatments. In the "x" axis, tidal volume (mL) and the "y" axis, end-tidal CO2 (mmHg). Note that alveolar volume behaves better during treatments 3 and 4.

Discussion

Despite the need to reduce morbidity and mortality of BPF therapy, particularly when associated with mechanical ventilation, little has been advanced in this field in the last decades. This study proposes a new method of reducing the output of a surgically created broncho-pulmonary fistula during mechanical ventilation, that improves alveolar volume, and, most importantly, does not cause any decrease in cardiac output or mean arterial blood pressure when compared with conventional water sealed drainage. The increased in cardiac output between Treatment 0 and 1 is probably due to the fact of increased preload and decreased after load of right ventricle (Table 1).

Several studies have described strategies to control BPF output during MV. However, these studies are mostly case reports and reviews, which failed to present an adequate solution to complications such as pneumothorax, hemodynamic instability, persistent air leak and severe hypoxemia. Published studies describe various forms of treatment, such as pressurization methods88. Bevelaqua FA, Kay S. A modified technique for the management of bronchopleural fistula in ventilator - dependent patients: a report of two cases. Respir Care. 1986;31(10):904-8. PMID: 2493107. , 9 9. Chaddouk EG. Bronchopleural fistula and mechanical ventilation: a simple technique of management?. J Thorac Cardiovasc Surg. 1995;110:1141-3. PMID: 7475145.ventilatory strategies and surgical techniques such as stent placement in the bronchial tree to try to stop the leak1010. Andreetti C, D'Andrilli A, Ibrahim M, Ciccone AM, Maurizi G, Mattia A, Venuta F, Rendina EA. Effective treatment of post-pneumonectomy bronchopleural fistual by conical fully covered self-expandable stent. Interact Cardiovasc Thorac Surg. 2012;14(4):420-3. PMID: 22268070.

11. Bellato V, Ferraloli GM, De Caria DD, Infante MV, Cariboni U, Spoto MR, Alloisio M, Bordone G. Management of postoperative bronchopleural fistula with a tracheobronchial stent in a patient requiring mechanical ventilation. Intensive Care Med. 2010;36:721-2. doi: 10.1007/s00134-010-1757-0.
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- 1212. Leo F, Solli P, Veronesi G, Galetta D, Petrella F, Gasparri R, Borri A, Spaggiari L. Review on bronchopleural fistula. Did a surgeon review it? Chest. 2006;129:1731-2. PMID: 16778298.. This demonstrates the heterogeneous nature of the problem and partially explains the non-standardization of therapy in BPF.

According to the majority of authors, the ideal treatment of BPF should not include the use of positive pressure11. Pierson DJ, Horton CA, Bates PW. Persistent bronchopleural air leak during mechanical ventilation. Chest. 1986;90(3):321-3. doi: 10.1378/chest.90.3.321.
https://doi.org/10.1378/chest.90.3.321...
, 88. Bevelaqua FA, Kay S. A modified technique for the management of bronchopleural fistula in ventilator - dependent patients: a report of two cases. Respir Care. 1986;31(10):904-8. PMID: 2493107.. However, this is often necessary, especially in cases of high output BPF44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
, 88. Bevelaqua FA, Kay S. A modified technique for the management of bronchopleural fistula in ventilator - dependent patients: a report of two cases. Respir Care. 1986;31(10):904-8. PMID: 2493107. , 1313. Downs JB, Chapman RL. Treatment of bronchopleural fistula during continuous positive pressure ventilation. Chest. 1976;69(3):363-6. PMID: 786563..

The increased mortality in patients with BPF under MV is the result of hypoventilation and consequent hypoxia. Minimizing the effects of air leakage while maintaining adequate arterial oxygenation may represent a conflicting demand imposed on MV11. Pierson DJ, Horton CA, Bates PW. Persistent bronchopleural air leak during mechanical ventilation. Chest. 1986;90(3):321-3. doi: 10.1378/chest.90.3.321.
https://doi.org/10.1378/chest.90.3.321...
.

Accordingly, we have developed an Adjustable Inspiratory Occlusion Valve (aIOV) that aims to treat high output BPF in patients undergoing positive pressure MV, specifically by reducing fistula output and improving ventilation without compromising hemodynamic parameters. In this study we have tried to measure its efficacy in pigs having a surgically created, high output BPF.

The assessment of efficacy was performed by volumetric capnography, a method that simplifies control of the ventilation by providing real-time, bedside data for alveolar ventilation. The volumetric capnography is widely applied in other diseases such as COPD1414. Qi GS, Gu WC, Yang WL, Xi F, Wu H, Liu JM. The ability of volumetric capnography to distinguish between chronic obstructive pulmonary disease patients and normal subjects. Lung. 2014;192(5):661-8. doi: 10.1007/s00408-014-9615-4.
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, 1515. Romero PV, Rodriguez B, de Oliveira D, Blanch L, Manresa F. Volumetric capnography and chronic obstructive pulmonary disease staging. Int J Chron Obstruct Pulmon Dis. 2007;2(3):381-91. PMID: 18229577., cystic fibrosis and noncystic fibrosis bronchiectasis1616. Veronez L, Moreira MM, Soares ST, Pereira MC, Ribeiro MA, Ribeiro JD, Terzi RG, Martins LC, Paschoal IA. Volumetric capnography for the evaluation of pulmonary disease in adult patients with cystic fibrosis and noncystic fibrosis bronchiectasis. Lung. 2010;188(3):263-8. doi: 10.1007/s00408-009-9213-z.
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17. Ribeiro MÂ, Silva MT, Ribeiro JD, Moreira MM, Almeida CC, Almeida-Junior AA, Ribeiro AF, Pereira MC, Hessel G, Paschoal IA. Volumetric capnography as a tool to detect early peripheric lung obstruction in cystic fibrosis patients. J Pediatr (Rio J). 2012;88(6):509-17. doi: 10.2223/JPED.2233.
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, pulmonary embolism2020. Moreira MM, Terzi RG, Cortellazzi L, Falcao AL, Moreno H, Jr., Martins LC, Coelho OR. Volumetric capnography: in the diagnostic work-up of chronic thromboembolic disease. Vasc Health Risk Manag. 2010;6:317-9. PMID: 20531949.

21. Pereira DJ, Moreira MM, Paschoal IA, Martins LC, Metze K, Moreno Junior H. Near-fatal pulmonary embolism in an experimental model: hemodynamic, gasometric and capnographic variables. Rev Bras Cir Cardiovasc. 2011;26(3):462-8. PMID: 22086585.

22. Moreira MM, Terzi RG, Pereira MC, Grangeia Tde A, Paschoal IA. Volumetric capnography as a noninvasive diagnostic procedure in acute pulmonary thromboembolism. J Bras Pneumol. 2008;34(5):328-32. PMID: 18545830.

23. Moreira MM, Terzi RG, Paschoal IA, Martins LC, Oliveira EP, Falcao AL. Thrombolysis in massive pulmonary embolism based on the volumetric capnography. Arq Bras Cardiol. 2010;95(4):e97-e9. PMID: 21180783.

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Each step of the experiment was conducted for no more than ten minutes, in order to avoid the hypoxia, hypercapnia and hemodynamic instability that were observed during the pilot study, when this time was extended. Mainly, because we did not increase inspiratory fraction of oxygen. It is believed that those problems were secondary to the high output BPF itself, and not to other methodological factors such as surgical incision or surgical time2727. Bellenger CR, Hunt GB, Goldsmid SE, Pearson MRB. Outcomes of thoracic surgery in dogs and cats. Am Vet J. 1996;74:25-30. PMID: 8894000.. Leite et al.2828. Leite CF, Calixto MC, Toro IFC, Antunes E, Mussi RK. Characterization of pulmonary and systemic inflammatory responses produced by lung re-expansion after one-lung ventilation. J Cardiothorac Vasc Anesth. 2012;26(3):427-32. doi: 10.1053/j.jvca.2011.09.028.
https://doi.org/10.1053/j.jvca.2011.09.0...
, using an experimental model of lung re-expansion after bronchial occlusion, found an acute lung inflammatory response, which has been shown to be more pronounced in long periods of bronchial occlusion in terms of cytokine inflammatory response. In addition, the magnitude of this inflammatory response also can be detected systemically2828. Leite CF, Calixto MC, Toro IFC, Antunes E, Mussi RK. Characterization of pulmonary and systemic inflammatory responses produced by lung re-expansion after one-lung ventilation. J Cardiothorac Vasc Anesth. 2012;26(3):427-32. doi: 10.1053/j.jvca.2011.09.028.
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, 2929. Wood JG, Johnson JS, Mattioli LF, Gonzalez NC. Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats. J Appl Physiol (1985). 2000;89:1561-8. PMID: 11007596..

In the present study we did not try, to establish a valve setting that would apply to every case of BPF under MV. Instead we believe that the use of volumetric capnography, by providing respiratory mechanics data in real time, allows for customization of the valve setting to each patient, expressing the individualized character of this therapy. It is however clear by the data presented that higher settings of the valve were associated with a better recovery of the respiratory mechanics.

Arterial blood gas analysis did not show the same behavior as alveolar ventilation. A possible explanation lies in the fact that the time between treatments (10 minutes) and the cumulative effect of previous treatments, might have not allowed complete normalization of the blood gases. In the present experiment, the FIO2 was kept at 0.21, in order to investigate the actual effectiveness of the method under atmospheric conditions. It is noticeable however that, the use of the valve was not associated with any significant worsening of oxygenation when compared to treatment with water seal.

Several strategies have been tried to treat patients with high output BPF needing MV. Oliveira et al.3030. Oliveira DG, Toneloto MG, Moreira MM, Bustorff-Silva JM, Souza GF, Martins LC, Kosour C, Dragosavac D, Falcão AL. Hemodynamic, ventilatory and gasometric evaluation of an experimental bronchopleural fistula. Acta Cir Bras. 2015;30(1):1-5. doi: 10.1590/S0102-86502015001000001.
https://doi.org/10.1590/S0102-8650201500...
using an experimental model of high output BPF demonstrated that a simple insertion of a water-sealed thoracic drain resulted in reduction in bronchopleural fistula output and better CO2 clearance without any drop in cardiac output or significant changes in mean arterial pressure. Shekar et al.44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
maintained the airway pressure below the opening pressure of the BPF, and then optimized the pleural suction pressure thus preventing aggravations. Additionally, Kempainem and Pierson33. Kempainen RR, Pierson DJ. Persistent Air leaks in patients receiving mechanical ventilation. Semin Respir Crit Care Med. 2001;22(6):675-84. PMID: 16088712.considered the use of low tidal volume and increased inspiratory/expiratory ratio, as a protective strategy of FBP under VM, because it reduces the peak pressure and avoids auto-PEEP. These authors proposed, in order to reduce the output of the FBP, the use of minimal levels of expiratory pressure, short inspiratory time, low tidal volume and low frequency44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
.

Other ventilatory strategies include high frequency MV (HFMV), which improves alveolar ventilation with consequent increase in arterial oxygen saturation, and independent lung ventilation by selective intubation33. Kempainen RR, Pierson DJ. Persistent Air leaks in patients receiving mechanical ventilation. Semin Respir Crit Care Med. 2001;22(6):675-84. PMID: 16088712. , 44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
.

Although some publications show clear benefits of HFV, such as better ventilation, lower peak pressure and lower mean airway pressure, this technique is not widely applied and is restricted to specialized centers3131. Ihra G, Gockner G, Kashanipour A, Aloy A. High-frequency jet ventilation in European and North American institutions: developments and clinical practice. Eur J Anaesthesiol. 2000;17(7):418-30. PMID: 10964143.. Furthermore, there are evidences that gas exchange might not be as satisfactory when the HFV is used in pulmonary diseases that concur with low pulmonary compliance22. Bishop MJ, Benson MS, Sato P, Pierson DJ. Comparison of high-frequency jet ventilation with conventional mechanical ventilation for bronchopleural fistula. Anesth Analg. 1987;66:833-8. PMID: 3304022..

Alternative strategies such as the occlusion of the chest tube may preserve the PEEP and reduce air leakage during inspiration, while allowing air to escape during the expiratory phase. This can be used in combination with the application of PEEP in the chest tube. Although these measures may help to maintain a small difference in transpulmonary pressure and reduce the risk of pulmonary collapse, they might also compromise the drainage of the pleural cavity and should be used with caution.

Some authors suggest the use of the suction of the drainage flask. However, the negative pressure applied to the chest tube to assist in drainage of the pleural space may increase transpulmonary pressure, resulting in an increase in the fistula output33. Kempainen RR, Pierson DJ. Persistent Air leaks in patients receiving mechanical ventilation. Semin Respir Crit Care Med. 2001;22(6):675-84. PMID: 16088712. , 44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
.

In patients with significant comorbidities or poor response to conservative treatment, non-surgical interventions to decrease the leak may provide temporary treatment, while the patient is stabilized for surgery33. Kempainen RR, Pierson DJ. Persistent Air leaks in patients receiving mechanical ventilation. Semin Respir Crit Care Med. 2001;22(6):675-84. PMID: 16088712. , 44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
.

Given the difficulties presented by the lack of standardized therapy to treat patients with BPF under MV and it's high mortality in the ICU, this study recommends a strategy that might be used in the presence of acute respiratory disorders arising from the fistula, to avoid additional complications while awaiting for better clinical conditions, that would permit surgical closure of fistula. Maung and Kaplan32 32. Maung AA, Kaplan LJ. Mechanical ventilation after injury. J Intensive Care Med. 2014;29(3):128-37. doi: 10.1177/0885066612457339.
https://doi.org/10.1177/0885066612457339...
reported that patients with injuries such as BPF, require mechanical ventilation to control not only the primary respiratory failure, but also as a complement to manage other conditions.

According to Shekar et al.44. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25:47-55. doi: 10.1016/j.jcrc.2009.05.007.
https://doi.org/10.1016/j.jcrc.2009.05.0...
, the success of therapy in cases of BPF will require strategies tailored to the individual patient needs. Accordingly, the method in question (volumetric capnography and occlusion valve), besides demonstrating the effectiveness of this valve, includes the concept of individualized therapy. In summary, this study demonstrated that it is possible, with the use of the adjustable inspiratory occlusion valve (aIOV), to reduce the leak of a BPF, with consequent improvement in alveolar volume, without compromising hemodynamic parameters, making this device a promising therapeutic tool for the treatment of BPF in patients on MV. The aIOV accepts different settings, going from 100% closed to 100% open, allowing it to be customized, in real time, to the hemodynamic needs and blood gases of the particular patient.

Conclusion

The occlusion valve decreased the bronchopulmonary fistula output, improved alveolar volume, without compromising the hemodynamic status when compared with conventional treatment (simple water-seal drainage).

Acknowledgements

To the team of the Center for Experimental Medicine and Surgery, Faculty of Medical Sciences, UNICAMP, especially to biologists Willian Adalberto Silva and Ana Cristina Moraes.

References

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  • Financial source: FAPESP (Process nº 04610-2/2009)
  • 1
    Research performed at Center for Experimental Medicine and Surgery, Faculty of Medical Sciences, Universidade de Campinas (UNICAMP), Brazil.

Publication Dates

  • Publication in this collection
    Aug 2015

History

  • Received
    11 Apr 2015
  • Reviewed
    14 June 2015
  • Accepted
    15 July 2015
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
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