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Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841

An. Bras. Dermatol. vol.90 no.3 Rio de Janeiro May/June 2015 


Comments on the article: "Update on therapy for superfi cial mycoses: review article part I"*

Fabiane Mulinari-Brenner1 

Luiz Eduardo Fabricio de Melo Garbers2 

Carla Cristina Marques1 

Patrícia Kiyori Watanabe1 

1Universidade Federal do Paraná (UFPR) – Curitiba (PR), Brazil.

2Faculdade Evangélica do Paraná (FEPAR) – Curitiba (PR), Brazil.

To the authors of the article: "Update on therapy for superficial mycoses: review article part I"1.

After going over the aforementioned article together with Dermatology Professors of the Hospital das Clínicas - UFPR, 3 items of this paper have provoked discussion, namely:

1) Perifolliculitis capitis abscedens et suffodiens, currently called dissecting cellulitis of the scalp, is classified as primary scarring alopecia since the 2000 consensus statement. Recent publications do not associate this condition with fungal colonization. 2 The 2013 paper "What's new in cicatricial alopecia?" indicates an inflammatory process that attacks and destroys the stem cells of hair follicles as the cause of this primary alopecia.3 Tchernev has described a disordered keratinization - which leads to the occlusion and accumulation of keratin at the hair follicle, followed by its dilation and rupture - as its main cause. This is justified not only by the induction of a granulomatous inflammatory process accompanied by the attraction of gigantic cells, partially phagocyting the keratin masses, but also by an infl ammatory bacterial process derived from a superinfection, most frequently caused by Staphylococcus aureus and Staphylococcus epidermidis (which are considered to be the main factors in the chemotaxis of neutrophils).4 This alopecia is irreversible even with appropriate therapy, due to the partial or complete destruction of the hair follicle caused by neutrophil infiltration and infiltration of giant cells. The association with other skin diseases resulting from follicular occlusion, such as hidradenitis suppurativa and acne conglobata suggests a common pathogenic mechanism based on follicular retention.

2) The black dots clinically observed in tinea capitis correspond to the comma or spiral-shaped hair seen in dermoscopy, rarely presenting as exclamation mark hair, a feature more suggestive of alopecia areata.5

3) Table 9 of the article shows griseofulvin as a therapeutic option for chronic mucocutaneous candidiasis, at a dose of 25 mg (initial dose) diluted in 500ml of glycosylated solution, and addition of 25 mg of hydrocortisone sodium succinate to the intravenous solution. This is probably a misprint. The correct drug would be amphotericin B. Other intravenous options include fluconazole and caspofungin. 5

Financial Support: None.

How to cite this article: Mulinari-Brenner FA, Garbers LEFM, Marques CC, Watanabe PK. Comments on the article: "Update on therapy for superfi cial mycoses: review article part I" . An Bras Dermatol 2015; 90(3):436-7

*Study conducted at the Universidade Federal do Paraná (UFPR) – Curitiba (PR), Brazil.


Dias MFRG, Quaresma-Santos MVP, Bernardes-Filho F, Amorim AGF, Schechtman RC, Azulay DR. Atualização terapêutica das micoses superficiais: artigo de revisão parte I. An Bras Dermatol. 2013;88(5):767-78. [ Links ]

Olsen EA, Bergfeld WF, Cotsarelis G, Price VH, Shapiro J, Sinclair R, et al. Sponsored Workshop on Cicatricial Alopecia. J Am Acad Dermatol. 2003;48:103-10. [ Links ]

Dogra S, Sarangal R. What's new in cicatricial alopecia?. Indian J Dermatol Venereol Leprol. 2013;79:576-90. [ Links ]

Tchernev G .Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin. Indian J Dermatol. 2011;56:318-20. [ Links ]

Pinheiro AMC, Lobato LA , Varella TCN. Dermoscopy findings in tinea capitis: case report and literature review. An Bras Dermatol. 2012;87:313-4. [ Links ]

Received: September 06, 2014; Accepted: September 10, 2014

MAILING ADDRESS: Fabiane Mulinari-Brenner, Hospital de Clínicas da Universidade Federal do Paraná, Departamento de Clínica Médica - Dermatologia. Rua General Carneiro, 181 - Alto da Glória, 80060-900 - Curitiba – PR - Brazil. E-mail:

Conflict of Interest: None.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.