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vol.34 issue3Laboratory diagnosis of chronic myelomonocytic leukemia and progression to acute leukemia in association with chronic lymphocytic leukemia: morphological features and immunophenotypic profileJulio Cesar Voltarelli 1948-2012 author indexsubject indexarticles search
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Revista Brasileira de Hematologia e Hemoterapia

Print version ISSN 1516-8484

Rev. Bras. Hematol. Hemoter. vol.34 no.3 São Paulo  2012

https://doi.org/10.5581/1516-8484.20120059 

IMAGES IN CLINICAL HEMATOLOGY

 

Myelophthisis as first manifestation of failure of chemotherapy in breast cancer

 

 

Leonardo Rodrigues de Oliveira; Thaís Camargos Ferreira; Antônio Carlos Oliveira de Meneses

Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brazil

Corresponding author

 

 

Myelophthisis is a form of bone marrow failure due to the substitution of hematopoietic tissue and its stroma by abnormal tissue(1,2). We report a case of a 38-year-old woman under investigation for bicytopenia during maintenance chemotherapy (tamoxifen) for breast cancer (diagnosed 3 years previously). Her physical examination was unremarkable except for pallor. There was no hepatosplenomegaly, lymphadenopathy or breast lesions. Laboratory tests showed normochromic and normocytic anemia (Hb 9.1 g/dL) and thrombocytopenia (117 x 109/L). A peripheral blood smear showed a typical leukoerythroblastic picture. Bone marrow aspiration (with resistance) and biopsy revealed extensive infiltration by breast ductal carcinoma.

 

 

 

 

References

1. Makoni SN, Laber DA. Clinical spectrum of myelophthisis in cancer patients. Am J Hematol. 2004;76(1):92-3.         [ Links ]

2. D'Angelo G, Hotz AM. Myelophthisis in breast cancer. Am J Hematol. 2011;86(1):70-1.         [ Links ]

 

 

Corresponding author:
Leonardo Rodrigues de Oliveira
Central de Quimioterapia - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro - UFTM
Rua Getúlio Guaritá, s nº
38025-440 Uberaba, MG, Brazil
leonardorodoli@hotmail.com

Submitted: 2/25/2012
Accepted: 4/9/2012
Conflict-of-interest disclosure: The authors declare no competing financial interest

 

 

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