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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Dement. neuropsychol. vol.2 no.3 São Paulo July/Sept. 2008 

Original Articles

Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)

Detectando comprometimento cognitivo em pacientes com doença de Parkinson com um instrumento breve de rastreio cognitivo: Addenbrooke's Cognitive Examination (ACE)

Anabel Chade 1   2  

María Roca 1   2  

Teresa Torralva 1   2  

Ezequiel Gleichgerrcht 1  

Nicolás Fabbro 2  

Gonzalo Gómez Arévalo 1   2  

Oscar Gershanik 1   2  

Facundo Manes 1   2  

1Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina.

2Institute of Neurosciences at Favaloro Foundation, Buenos Aires, Argentina.


Detecting cognitive impairment in patients with Parkinson's disease is crucial for good clinical practice given the new therapeutic possibilities available. When full neuropsychological evaluations are not available, screening tools capable of detecting cognitive difficulties become crucial.


The goal of this study was to investigate whether the Spanish version of the Addenbrooke's Cognitive Examination (ACE) is capable of detecting cognitive difficulties in patients with Parkinson's disease and discriminating their cognitive profile from patients with dementia.


77 early dementia patients (53 with Alzheimer's Disease and 24 with Frontotemporal Dementia), 22 patients with Parkinson's disease, and 53 healthy controls were evaluated with the ACE.


Parkinson's disease patients significantly differed from both healthy controls and dementia patients on ACE total score.


This study shows that the Spanish version of the ACE is capable of detecting patients with cognitive impairment in Parkinson's disease and is able to differentiate them from patients with dementia based on their general cognitive status.

Key words: Parkinson's disease; Alzheimer's disease; frontotemporal dementia; screening tools; Addenbrooke's Cognitive Examination (ACE).


A detecção de comprometimento cognitivo em pacientes com doença de Parkinson é crucial para uma boa prática clínica devido às novas possibilidades terapêuticas disponíveis. Quando uma avaliação neuropsicológica completa não está disponível, instrumentos de rastreio capazes de detectar dificuldades cognitivas tornam-se cruciais.


Investigar se a versão espanhola do Addenbrooke´s Cognitive Examination (ACE) é capaz de detectar dificuldades cognitivas em pacientes com doença de Parkinson e discriminar seu perfil cognitivo de pacientes com demência.


77 pacientes com demência leve (53 com doença de Alzheimer e 24 com demência frontotemporal), 22 pacientes com doença de Parkinson e 53 controles saudáveis foram avaliados com a ACE.


Os pacientes com doença de Parkinson significativamente diferiram de controles saudáveis e pacientes com demência no escore total do ACE.


Este estudo mostra que a versão espanhola do ACE é capaz de detectar pacientes com comprometimento cognitivo na doença de Parkinson e de diferenciá-los de pacientes com demência baseados no seu estado cognitivo geral.

Palavras-chave: doença de Parkinson; doença de Alzheimer; demência frontotemporal; instrumentos de rastreio; Exame Cognitivo de Addenbrooke.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.


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Received: July 17, 2008; Accepted: August 21, 2008

Facundo Manes - Instituto de Neurología Cognitiva (INECO) - Castex 3293 (1425) - Buenos Aires, Argentina. E-mail:


These authors contributed equally to this study.

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