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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Dement. neuropsychol. vol.7 no.2 São Paulo Apr./June 2013

http://dx.doi.org/10.1590/S1980-57642013DN70200006 

ORIGINAL ARTICLES

Neuropsychiatric symptoms and severity of dementia

Sintomas Neuropsiquiátricos e Gravidade da Demência

Gustavo Henrique de Oliveira Caldas1 

Sueli Luciano Pires2 

Milton Luiz Gorzoni3 

1Resident in Geriatrics Fellowship of Santa Casa de São Paulo (ISCMSP), São Paulo SP, Brazil;

2Teaching Professor, Santa Casa de São Paulo Medical School and Technical Director of the Hospital Geriátrico e de Convalescentes Dom Pedro II of ISCSMSP, São Paulo SP, Brazil;

3Adjunct Professor and Coordinator of Disciplines of Geriatrics and Gerontology Fundamentals - Santa Casa de São Paulo Medical School, São Paulo SP, Brazil.

ABSTRACT

Neuropsychiatric symptoms (NPS) cause distress, disabilitiy and reduced quality of life for both the patient and their families Objective: To evaluate the prevalence of NPS as a specific stage of dementia status. Methods: A cross-sectional study in patients attending an outpatient clinic for dementia was performed. We applied the Neuropsychiatric Inventory and Clinical Dementia Rating (CDR) scale. Statistical analysis was carried out with SPSS 17 software. Results: The 124 subjects (mean age of 80.4±7.0 years), 88 women (70.9%) had average duration of dementia of 7.1±3.2 years, most common dementias of Alzheimer's disease (35.5%) and mixed (31.5%) and most prevalent NPS of apathy (75%) and irritability (66.9%). Correlation between apathy and a CDR 1 had a PR (prevalence ratio) = 0.289 and p<0.001 while between apathy and CDR 4-5 (PR=8.333, p<0.005). A similar result was found between aberrant motor behavior (AMB) and CDR 1 (PR=0.352, p<0.003) and between AMB and CDR4-5 (PR=2.929, p<0.006). Conclusion: Alzheimer's disease and mixed dementia were predominant, while apathy and AMB were detected in association with the progressive stages of dementia.

Key words: elderly; dementia; neuropsychiatric symptoms; behavioral and psychological symptoms in dementia

RESUMO

Sintomas neuropsiquiátricos (SNPs) causam sofrimento, incapacidade e redução da qualidade de vida do paciente e das famílias. Objetivo: Avaliar a prevalência de SNPs específicos conforme a fase do estado demencial. Métodos: Estudo transversal em pacientes atendidos em ambulatório de demências. Aplicou-se Inventário Neuropsiquiátrico e Clinical Dementia Rating (CDR). Realizada análise estatística com o software SPSS 17. Resultados: 124 idosos (idade média de 80,4±7,0 anos), 88 mulheres (70,9%). Tempo médio de demência: 7,1±3,2 anos. Demências mais frequentes: doença de Alzheimer (35,5%) e mista (31,5%). Sintomas neuropsiquiátricos mais prevalentes: apatia (75%) e irritabilidade (66,9%). Correlação entre apatia e CDR 1 tem RP (razão de prevalências) = 0,289 e p<0,001 e entre apatia e CDR 4-5; RP=8,333; p<0,005, o mesmo ocorrendo entre comportamento motor aberrante (CMA) e CDR 1 (RP=0,352; p<0.003) e CMA e CDR4-5 (RP=2,929; p<0,006). Conclusão: Houve predomínio de demência de Alzheimer e demência mista e se detectou apatia e CMA em associação progressiva com as fases do quadro demencial.

Palavras-chave: idoso; demência; sintomas neuropsiquiátricos; sintomas psicológicos e comportamentais nas demências

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Received: December 07, 2012; Accepted: April 02, 2013

Gustavo Henrique de Oliveira Caldas. Hospital Geriátrico Dom Pedro II - Avenida Guapira, 2674 - 02265-002 São Paulo SP - Brazil. E-mail: gustavohocaldas@yahoo.com.br

Disclosure: The authors report no conflicts of interest

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