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Abstract Anthropogenic interventions have had a compromising effect on environmental health, intensifying the degradation of ecosystems, and the quantity of chemical pollutants released into nature. Therefore, research areas within the scope of environmental assessments and monitoring such as ecotoxicology have contributed to the determination of the toxic potential of contaminants. A small cyprinid known as the zebrafish (Danio rerio), the use of which has exponentially grown, is an alternative vertebrate model for scientific research, mainly in the assessment of environmental risks. The species exhibits several advantages for breeding in a laboratory, in addition to presenting multi-biomarkers of environmental toxicity. Thus, this review aims to present the main characteristics and advantages of working with this species, as well as show studies related to ecotoxicology involving biomarkers of toxicity in zebrafish. The results show a progressive trend towards employing the species in environmental risk analyses, it is an increasingly recommended species in the assessment of the toxicity level of a range of chemical pollutants. The development of future technologies must contribute to scientific advancement, rendering the potential application of this model organism an even more widespread one, which will certainly help in bridging knowledge gaps in various areas of study.

https://doi.org/10.1590/1678-4324-2024220968

Estrategias y recomendaciones para enfrentar la enfermedad por virus respiratorio sincicial el año 2024
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Paris, Enrique

; Daza, Paula

; Tapia, Lorena

; Díaz, Juan Pablo

; Cruces Romero, Pablo

; Castillo, Andrés

; González, Cecilia

; Endeiza, María Luz

; Jofré, Leonor

; Castro, Fabiola

; Zamorano, Alejandra

; Rodríguez, Jaime

; Acevedo, Johanna

; Santa Cruz, Teresita

; González, Jaime

; Escárate, Raúl

; Moreno, Juan Pablo

; Cisternas, Paula

Andes pediatrica

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2024, N. ahead

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: Durante el invierno de 2023, Chile enfrentó una compleja situación relacionada con al virus respiratorio sincicial (VRS). Después de experimentar una disminución en la circulación del VRS durante los años de la pandemia de SARS-CoV-2, se observó un brote tardío en la primavera de 2022 y un inicio anticipado del brote en 2023, con un aumento significativo en el número de casos graves. La poca efectividad en la planificación estratégica y comunicación de riesgo contribuyeron a la complejidad de la situación. Para evitar lo anterior el próximo invierno, se sugieren medidas como vigilancia activa, unificación de definiciones para infecciones respiratorias agudas, identificación de variantes del VRS, educación pública sobre contagios y preparación anticipada respecto a camas hospitalarias y personal de salud. Se destaca la importancia de la inmunización y colaboración intersectorial para adquirir nuevas alternativas preventivas como también la necesidad de una comunicación temprana sobre la importancia de la inmunización e identificación de grupos de alto riesgo, mejora en capacitaciones del personal médico y planificación estratégica del Ministerio de Salud buscando un enfoque proactivo y colaborativo para abordar la compleja situación del VRS en futuros inviernos. El Comité Asesor en Vacunas y Estrategias de Inmunización de Chile ya realizó un análisis y recomendación sobre una nueva alternativa de prevención. Este grupo de trabajo apoyará cualquier decisión del Ministerio de Salud en políticas públicas que intenten un cambio en el paradigma del control de esta enfermedad por la salud de los niños/as de nuestro país.

Abstract: During the winter of 2023, Chile faced a complex situation related to the respiratory syncytial virus (RSV). After experiencing a decline in RSV circulation during the years of the SARS-CoV-2 pandemic, a late outbreak was observed in the spring of 2022 and an early onset of the outbreak in 2023, with a significant increase in the number of serious cases. The ineffectiveness of strategic planning and risk communication contributed to the complexity of the situation. To avoid the above next winter, measures such as active surveillance, unification of definitions for acute respiratory infections, identification of RSV variants, public education about infections and advance preparation regarding hospital beds and health personnel are suggested. The importance of immunization and intersectoral collaboration to acquire new preventive alternatives is highlighted, as well as the need for early communication about the importance of immunization and identification of high-risk groups, improvement in training of medical personnel and strategic planning of the Ministry of Health. seeking a proactive and collaborative approach to address the complex RSV situation in future winters. The Chilean Immunization Advisory Committee has already carried out an analysis and recommendation on a new prevention alternative. This working group will support any decision of the Ministry of Health in public policies that attempt a change in the paradigm of control of this disease for the health of the children of our country.

https://doi.org/10.32641/andespediatr.v95i1.5055

Memorias colectivas, medios de comunicación alternativa y post acuerdo
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Cruz-Castillo, Alba Lucía

; Martínez-Calderón, Alejandra

; Acosta-Angulo, Juanita

; Vásquez-Gómez, María Paula

; Barrera-Rincón, Andrés Felipe

Universitas-XXI, Revista de Ciencias Sociales y Humanas

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dec 2023, N. 39 Pages 229 - 253

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Este texto ilustra el rol de los medios de comunicación alternativos frente a la denuncia y visibilización de casos de desaparición forzada y asesinato de líderes sociales después de la firma del Acuerdo de Paz en el 2016 en el Departamento del Meta-Colombia. A partir de ello, la investigación que se relata en este artículo, pretende nombrar a los líderes, sus territorios, el rol que desempañaban en sus comunidades para enunciar las particularidades de los sujetos que aún siguen sufriendo de estas afectaciones; los posibles responsables y la relevancia que tienen los medios de comunicación alternativos en hacerlos visibles, para la construcción de memoria colectiva. Para ello se realizó un análisis de datos de tipo documental y de contenido durante el periodo 2017-2020, que da cuenta de las diversas formas de informar y denunciar estas afectaciones. La investigación aporta en posicionar la relevancia de estos medios de comunicación alternativos en la construcción de memoria colectiva y el no olvido de estas afectaciones como hechos sociales y políticos transcendentes y que estos medios a través de narrativas multimediales a partir de diversos formatos textuales, gráficas, sonoros y fotográficos se posicionan en las plataformas virtuales visibilizando la voz de las familias y comunidades que denuncian y buscan a sus familiares que intentan reivindicar su derecho a la verdad, reparación y memoria.

Abstract This text illustrates the role of the alternative media in the denunciation and visibility of cases of forced disappearance and murder of social leaders after the signing of the Peace Agreement in 2016 in the Department of Meta-Colombia; Based on this, the research that this article reports, proposes to name the leaders, their territories, the role they played in their communities in order to state the particularities of the subjects who still continue to suffer from these affectations; the possible authors and the relevance that the alternative media have in making them visible, in favor of the construction of collective memory. For this, an analysis of documentary and content data was carried out, which accounts for the various ways of reporting and denouncing these affectations. The research contributes to positioning the relevance of these alternative communication media have in the construction of collective memory and not forgetting these affectations as transcendental social and political facts and that these media through multimedia narratives from various textual, graphic formats , sound and photographic are positioned on virtual platforms making visible the voice of families and communities that denounce and seek their relatives who try to claim their right to truth, reparation and memory.

https://doi.org/10.17163/uni.n39.2023.10

[SciELO Preprints] - TAGENCIAMENTOSHOUGHT-BODY IN POSTGRADUATION: AGENCIES IN THE CONSTRUCTION OF KNOWLEDGE AND PRACTICES IN CIRCLE GUIDANCE WITH WOMEN IN THE HEALTH FIELD
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Jimenez, Maria Luisa Cruz, Kathleen Teresa da Gomes, Maria Paula Cerqueira

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Publication date: 2023-11-01

Abstract: En Es Pt

This article addresses for construction of a knowledge finds laid out in rhizomatic perspective of Deleuze and Guattari, which opposes the fragmented and hierarchical idea of knowledge production. It is important to highlight how academic training is still influenced by male references, which impacts the construction of concepts and the hierarchization of knowledge. This is a cartographic study based on experiences of female advisor professors from a Postgraduate Health Program in psychosociology.  In this role is proposed a manage work approach with local values and dissident knowledge, in which self-care and guidance relationships are a partnership of meetings, listening and affection. Postgraduate teaching practice is a solitary experience, requiring many meetings between supervisor and student. The challenge of rethinking and reconfiguring teaching practice, breaking with the hegemonic, hierarchical model in the construction of knowledge collectively, is a task that requires creativity and courage. It is necessary to overcome the difficulties imposed by patriarchal institutions and overcome the idea of centralized leadership. The construction of knowledge in collective, with autonomy and respect for differences, is fundamental for the creation of possible new worlds and the reinvention of subjectivity. It is important to value the feeling in female bodies as a source of thought and experimentation, breaking with traditional thinking and opening space for new ways for guidance in teaching practice. The taking care of yourself and of relationships are essential for the construction of new forms of subjectivity, which promote mutual care and the construction of decolonial and anti-racist knowledge.

Este artículo aborda la construcción de conocimiento desde la perspectiva rizomática en Deleuze y Guattari, que se opone a la idea fragmentada y jerárquica de producción de conocimiento. Es importante resaltar cómo la formación académica aún está influenciada por referentes masculinos, lo que impacta en la construcción de conceptos y la jerarquización de conocimientos. A partir de registros cartográficos, con las experiencias de docentes mentores en un Programa de Posgrado en Salud en psicosociología, se propone un enfoque que valora saberes locales y disidentes, en los que las relaciones de autocuidado y orientación son una alianza de encuentros, escuchas y afectos. La práctica docente de posgrado es una experiencia solitaria que requiere muchas reuniones entre supervisor y estudiante. El desafío de repensar y reconfigurar la práctica docente, rompiendo con el modelo hegemónico y jerárquico en la construcción colectiva del conocimiento, es una tarea que requiere creatividad y valentía. Es necesario superar las dificultades que imponen las instituciones patriarcales y superar la idea de liderazgo centralizado. La construcción de conocimiento colectivo, con autonomía y respeto a las diferencias, es fundamental para la creación de mundos posibles y la reinvención de la subjetividad. Es importante valorar las cuerpas como fuente de pensamiento y experimentación, rompiendo con el pensamiento fijo y abriendo espacio a la experimentación. El cuidado de uno mismo y de las relaciones es fundamental para la construcción de nuevas formas de subjetividad, que promuevan el cuidado mutuo y la construcción de saberes decoloniales y antirracistas.

O presente artigo aborda a construção de conhecimento a partir da perspectiva rizomática em Deleuze e Guattari, que se opõe à ideia fragmentada e hierarquizada de produção de saberes. É importante destacar como a formação acadêmica ainda é influenciada por referências masculinas, o que impacta na construção de conceitos e na hierarquização do conhecimento. A partir de registros cartográficos, com as experiências de professoras orientadoras de um Programa de Pós-graduação em saúde em psicossociologia, propõe-se uma abordagem que valorize saberes locais e dissidentes, em que o cuidado de si e das relações de orientação seja uma parceria de encontros, escuta e afetos. A prática docente na pós-graduação é uma experiência solitária, exigindo muitos encontros entre orientadora e orientanda. O desafio de repensar e reconfigurar a prática docente, rompendo com o modelo hegemônico, hierárquico na construção de conhecimento coletivamente, é uma tarefa que exige criatividade e coragem. É preciso superar as dificuldades impostas por instituições patriarcais e ultrapassar a ideia de liderança centralizada. A construção de conhecimento em coletivo, com autonomia e respeito às diferenças, é fundamental para a criação de mundos possíveis e a reinvenção da subjetividade. É importante valorizar as corpas como fonte de pensamento e experimentação, rompendo com o pensamento fixo e abrindo espaço para a experimentação. O cuidado de si e das relações é essencial para a construção de novas formas de subjetividade, que promovam o cuidado mútuo e a construção de saberes decoloniais e antirracistas.

https://doi.org/10.1590/SciELOPreprints.7195

Frecuencia de eventos cardiovasculares en pacientes con lupus eritematoso sistémico.
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García, Lucila

; Gobbi, Carla

; Quintana, Rosana

; Alba, Paula

; Roverano, Susana

; Álvarez, Analía

; Graf, César

; Pisoni, Cecilia

; Spindler, Alberto

; Gómez, Catalina

; Figueredo, Heber Matías

; Papasidero, Silvia

; Paniego, Raúl

; de la Vega, María Celina

; Civit, Emma

; González Lucero, Luciana

; Martire, María Victoria

; Maldonado Aguila, Rodrigo

; Gordon, Sergio

; Micelli, Marina

; Nieto, Romina

; Rausch, Gretel

; Gongora, Vanina

; Damico, Agustina

; Dubinsky, Diana

; Orden, Alberto

; Zacariaz, Johana

; Romero, Julia

; Pera, Mariana

; Goñi, Mario

; Rillo, Oscar

; Báez, Roberto

; Arturi, Valeria

; González, Andrea

; Vivero, Florencia

; Bedoya, María Eugenia

; Shmid, Marcela

; Caputo, Víctor

; Larroude, María Silvia

; Domínguez, Nadia

; Gómez, Graciela

; Rodríguez, Graciela

; Marín, Josefina

; Collado, Victoria

; Jorfen, Marisa

; Bedran, Zaida

; Curti, Ana

; Gazzoni, María Victoria

; Sarano, Judith

; Finucci Curi, Pablo

; Rojas Tessel, Romina

; Arias Saavedra, Maira

; Sattler, María Emilia

; Machado Escobar, Maximiliano

; Astesana, Pablo

; París, Úrsula

; Vandale, Juan Manuel

; Santa Cruz, María Julia

; Pons-Estel, Bernardo

; García, Mercedes

Revista argentina de reumatología

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oct 2023, Volume 34 N. 2 Pages 43 - 50

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: el progreso en los tratamientos para el lupus eritematoso sistémico (LES) resultó en una disminución de la mortalidad; sin embargo, la enfermedad cardiovascular y las complicaciones infecciosas aún son las principales causas de muerte. La evidencia apoya la participación del sistema inmunológico en la generación de la placa aterosclerótica, así como su conexión con las enfermedades autoinmunes. Objetivos: describir la frecuencia de eventos cardiovasculares (ECV) en el Registro de Lupus Eritematoso Sistémico de la Sociedad Argentina de Reumatología (RELESSAR) transversal, así como sus principales factores de riesgo asociados. Materiales y métodos: estudio descriptivo y transversal para el cual se tomaron los pacientes ingresados en el registro RELESSAR transversal. Se describieron las variables sociodemográficas y clínicas, las comorbilidades, score de actividad y daño. ECV se definió como la presencia de al menos una de las siguientes patologías: enfermedad arterial periférica, cardiopatía isquémica o accidente cerebrovascular. El evento clasificado para el análisis fue aquel posterior al diagnóstico del LES. Se conformaron dos grupos macheados por edad y sexo 1:2. Resultados: 1515 pacientes mayores de 18 años participaron del registro. Se describieron 80 pacientes con ECV (5,3%). En este análisis se incluyeron 240 pacientes conformando dos grupos. La edad media fue de 47,8 (14,4) y 47,6 (14,2) en el grupo con y sin ECV respectivamente. Los pacientes con ECV tuvieron mayor duración del LES en meses, mayor índice de Charlson, mayor SLICC (Systemic Lupus International Collaborating Clinics/American College of Rheumatology), mayor frecuencia de manifestaciones neurológicas, síndrome antifosfolípido, hospitalizaciones y uso de ciclofosfamida. Las únicas variables asociadas en el análisis multivariado fueron el índice de Charlson (p=0,004) y el SLICC (p<0,001). Conclusiones: los ECV influyen significativamente en nuestros pacientes, y se asocian a mayor posibilidad de daño irreversible y comorbilidades.

Abstract Introduction: progress in treatments for systemic lupus erythematosus (SLE) has resulted in a decrease in mortality; however, cardiovascular and infectious diseases remain the leading causes of death. Evidence supports the involvement of the immune system in the generation of atherosclerotic plaque, as well as its connection to autoimmune diseases. Objectives: to describe the frequency of cardiovascular disease (CVD) in the cross-sectional RELESSAR registry, as well as its associated variables. Materials and methods: a descriptive and cross-sectional study was performed using patients admitted to the cross-sectional RELESSAR registry. Sociodemographic variables, clinical variables, comorbidities, activity and damage scores were described. CVD was defined as at least one of the following: peripheral arterial disease, ischemic heart disease, or cerebrovascular accident. All patients with at least one CVD were included in our analysis (heart attack, central nervous system vascular disease, and peripheral arteries atherosclerotic disease). The event classified for the analysis was that after the diagnosis of SLE. SLE diagnosis was previous to CVD. Two groups matched by age and sex, 1:2 were formed. Results: a total of 1515 patients older than 18 years participated in the registry. Eighty patients with CVD (5.3%) were described in the registry. Two-hundred and forty patients were included, according to two groups. The mean age was 47.8 (SD 14.4) and 47.6 (SD 14.2) in patients with and without CVD, respectively. Patients with CVD had a longer duration of SLE in months, a higher Charlson index, a higher SLICC, increased frequency of neurological manifestations, antiphospholipid syndrome, hospitalizations, and use of cyclophosphamide. The associated variables in the multivariate were the Charlson Index (p=0.004) and the SLICC (p<0.001). Conclusions: CVDs have a significant influence on our patients, being associated with a greater possibility of damage and comorbidities.

https://doi.org/10.47196/rar.v34i2.747

Síndrome De Debilidad Crónica Como Presentación Del Síndrome Postpolio
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Cárdenas-Cruz, Andrés Felipe

; Aguilera-Pena, María Paula

; Santana, Julián

; Guzmán-Serrano, Carlos Alberto

; Millán, Sonia

Revista Ecuatoriana de Neurología

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sep 2023, Volume 32 N. 2 Pages 105 - 110

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: El síndrome postpolio (SPP) se caracteriza por debilidad progresiva, fatiga muscular, dolor articular y aumento de la discapacidad, que se produce décadas después del episodio agudo de poliomielitis. Se desconoce la causa del deterioro neurológico progresivo; sin embargo, las principales hipótesis sugieren inducción de autoinmunidad. No existen hallazgos patognomónicos ni pruebas específicas para el síndrome post polio, por lo que, el diagnóstico se realiza en base a la clínica y a los antecedentes de un episodio de poliomielitis al menos 15 años antes de la aparición de nuevos síntomas. A continuación, presentamos el caso de un hombre, con antecedente de poliomielitis, que aproximadamente 40 años después presentó una lenta progresión de la debilidad, arreflexia, atrofia y fasciculaciones. Aunque la frecuencia del síndrome postpolio es baja, los síntomas son incapacitantes y provocan un gran deterioro de la funcionalidad del paciente. Dado que no existe un tratamiento específico, el manejo es principalmente sintomático y de soporte.

Summary: Post-polio syndrome (PPS) is characterized by progressive weakness, muscle fatigue, joint pain, and an increase in disability, which occurs decades after an episode of poliomyelitis. The cause of progressive neurological deterioration is unknown; however, the main hypotheses suggest induction of autoimmunity. There are no pathognomonic findings or specific tests that diagnose PPS; therefore, the diagnosis is made based on the clinic and the history of a polio episode at least 15 years before the onset of new symptoms. We present a case of a man,with a history of poliomyelitis who approximately 40 years later presents a slow progression of weakness, areflexia, atrophy, and fasciculation. Although the frequency of PPS is low, symptoms are disabling, and they cause great impairment in the patient’s functionality. Since there is no specific treatment, the management of PPS is mainly symptomatic and supportive.

https://doi.org/10.46997/revecuatneurol32200105

Política de Saúde Bucal no Brasil: transformações e rupturas entre 2018-2021
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Santos, Lília Paula de Souza

; Lima, Ana Maria Freire de Souza

; Chaves, Sônia Cristina Lima

; Vilela, Débora Maria Oliveira Cruz

; Valente, Ana Paula Portugal Chagas

; Rossi, Thaís Regis Aranha

Ciência & Saúde Coletiva

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may 2023, Volume 28 N. 5 Pages 1575 - 1587

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Analisou-se a implementação da Política de Saúde Bucal no Brasil no período 2018-2021, através das ações institucionais, implantação dos serviços, resultados alcançados e financiamento federal. Estudo de monitoramento, a partir da análise documental e de dados secundários, obtidos em sites institucionais, sistemas de informações governamentais e notícias publicadas por entidades odontológicas. Todos os indicadores de resultados monitorados apresentaram expressiva redução dos valores entre 2020-2021, com agravamento desde 2018, como a cobertura da primeira consulta odontológica e ação coletiva de escovação dental supervisionada, que chegou a 1,8% e 0,02% em 2021, respectivamente. Observa-se uma queda do financiamento federal nos anos 2018-2019 (8,45%), com crescimento em 2020 (59,53%) e nova diminuição em 2021 (5,18%). O período analisado foi marcado por crise econômica e política, agravadas pela crise sanitária, decorrente da pandemia do COVID-19. Contexto que influenciou o funcionamento dos serviços de saúde no Brasil. No caso particular da saúde bucal, verificou-se progressiva e acentuada redução dos resultados, ainda que a implantação dos serviços de atenção básica e especializada tenha se mantido estável.

Abstract This study analyzed the implementation of Brazil’s National Oral Health Policy during the period 2018-2021, covering institutional actions, implementation of public dental services, results achieved, and federal funding. We conducted a retrospective descriptive study using documentary analysis and secondary data obtained from institutional websites, government information systems, and reports published by dental organizations. The findings show a significant reduction in funding between 2020 and 2021 and declining performance against indicators since 2018, such as coverage of first dental appointments and group supervised tooth brushing, which stood at 1.8% and 0.02%, respectively, in 2021. Federal funding dropped in 2018 and 2019 (8.45%), followed by an increase in 2020 (59.53%) and decrease in 2021 (-5.18%). The study period was marked by economic and political crises aggravated by the COVID-19 pandemic. This context influenced the functioning of health services in Brazil. There was a sharp reduction in performance against oral health indicators, while performance in primary health care and specialized care services remained stable.

https://doi.org/10.1590/1413-81232023285.14002022

Política de Saúde Bucal no Brasil: transformações e rupturas entre 2018-2021
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Santos, Lília Paula de Souza

; Lima, Ana Maria Freire de Souza

; Chaves, Sônia Cristina Lima

; Vilela, Débora Maria Oliveira Cruz

; Valente, Ana Paula Portugal Chagas

; Rossi, Thaís Regis Aranha

Ciência & Saúde Coletiva

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may 2023, Volume 28 N. 5 Pages 1575 - 1587

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232023285.14002022

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition
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Pinto, Marcus Vinicius

; França Jr, Marcondes Cavalcante

; Gonçalves, Marcus Vinicius Magno

; Machado-Costa, Marcela Câmara

; Freitas, Marcos Raimundo Gomes de

; Gondim, Francisco de Assis Aquino

; Marrone, Carlo Domenico

; Martinez, Alberto Rolim Muro

; Moreira, Carolina Lavigne

; Nascimento, Osvaldo J. M.

; Covaleski, Anna Paula Paranhos

; Oliveira, Acary Souza Bulle de

; Pupe, Camila Castelo Branco

; Rodrigues, Marcia Maria Jardim

; Rotta, Francisco Tellechea

; Scola, Rosana Herminia

; Marques Jr, Wilson

; Waddington-Cruz, Márcia

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 308 - 321

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript.

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito.

https://doi.org/10.1055/s-0043-1764412

10.

National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas

; França, Ana Paula

; Guibu, Ione Aquemi

; Vasconcellos, Maurício Teixeira Leite de

; Moraes, José Cássio de

; Teixeira, Maria da Gloria Lima Cruz

; Domingues, Carla Magda Alan

; Borges, Maria Fernanda de Souza Oliveira

; de Azevedo, Roberta Nogueira Calandrini

; de Oliveira, Consuelo Silva

; Oliveira, Andrea de Nazaré Marvão

; Canales, Ivy Thereza

; Nascimento, Valdir

; Queiroz, Rejane Christine de Souza

; Lima, Luísa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Barbosa, Jaqueline Caracas

; Mirabal, Isabelle Ribeiro Barbosa

; Meira, Meiruska

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria Denise de Castro

; Gurgel, Ricardo Queiroz

; de Carvalho, Martha Suely Itaparica

; Cesar, Tayñana

; Maciel, Ethel Leonor Noia

; da Gama, Silvana Granado Nogueira

; Luhm, Karin Regina

; Boing, Antônio Fernando

; Mengue, Sotero Serrate

; de Oliveira, Sandra Maria do Valle Leone

; Lima, Jaqueline Costa

; Teles, Sheila Araújo

; Caetano, Karlla Antonieta Amorim

; de Araújo, Wildo Navegantes

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230031

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Inquérito nacional de cobertura vacinal aos 12 e 24 meses de idade foi realizado para investigar as quedas nas coberturas a partir de 2016. Métodos: Amostra de 37.836 nascidos vivos das coortes de 2017 e 2018 residentes nas capitais, Distrito Federal (DF) e 12 cidades com mais de 100 mil habitantes, acompanhados nos primeiros 24 meses por registros nas cadernetas de vacinação. Setores censitários foram estratificados segundo condições socioeconômicas, e o mesmo número de crianças foi incluído para cada estrato. Calcularem-se coberturas vacinais de cada vacina e coberturas completas aos 12 e 24 meses, doses aplicadas, válidas e oportunas. Fatores familiares, maternos e da criança associados à cobertura foram pesquisados. Os motivos para não vacinar analisados foram: contraindicações médicas, dificuldades de acesso, problemas no funcionamento do programa e hesitação vacinal. Resultados: Os resultados preliminares mostram que menos de 1% das crianças não foram vacinadas, as coberturas pelo esquema completo são menores que 75% em todas as capitais e no DF, as vacinas com mais de uma dose perdem cobertura progressivamente, há diferenças entre os estratos socioeconômicos, favoráveis aos estratos mais altos em algumas cidades e aos estratos mais baixos em outras. Conclusão: Houve realmente redução da cobertura vacinal em todas as capitais e no DF para as crianças nascidas em 2017 e 2018, denotando piora na execução do Programa Nacional de Imunizações durante os anos de 2017 a 2019. O inquérito realizado não mensurou os impactos da pandemia de COVID-19 que podem ter reduzido ainda mais as coberturas vacinais.

ABSTRACT Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016. Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy. Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others. Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.

https://doi.org/10.1590/1980-549720230031

11.

O trabalho de Enfermagem a partir da experiência de enfermeiras da linha de frente contra Covid-19: na trilha da precarização
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Souza, Diego de Oliveira

; Santos, Maria Leticia Cavalcante

; Santos, Emanuelle Pereira de Araújo

; Magalhães, Ana Paula Nogueira de

; Cruz, Sabrina Ângela França da Silva

Interface - Comunicação, Saúde, Educação

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2023, Volume 27 elocation e230021

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

A experiência de trabalhar no enfrentamento da Covid-19, em meio a um processo tenso, contraditório e com repercussões na própria saúde, constitui o contexto desta pesquisa, que tem o objetivo de entender o trabalho de Enfermagem na experiência de enfermeira(o)s da linha de frente contra a Covid-19, em Alagoas, Brasil. Trata-se de pesquisa qualitativa, com análise de conteúdo das histórias orais temáticas de seis enfermeiras que atuaram na linha de frente das cidades de Arapiraca e Maceió, estado de Alagoas, Brasil. As categorias temáticas que se destacaram na análise foram: desvalorização; ausência de estrutura física e de recursos para o trabalho; vínculo precário de trabalho; e relação entre sobrecarga, adoecimento e desgaste. Constatou-se que essas categorias compõem o que tem sido chamado de precarização do trabalho, já estabelecida anteriormente, mas amplificada na pandemia, a exemplo da experiência das trabalhadoras de Enfermagem.

La experiencia de trabajar en el enfrentamiento de la Covid-19, en el medio de un proceso tenso, contradictorio, con repercusiones sobre la propia salud, constituye el contexto de esta investigación, con el objetivo de entender el trabajo de enfermería en la experiencia de enfermeros(as) de la línea de frente contra la Covid-19, en Alagoas, Brasil. Se trata de una investigación cualitativa con análisis del contenido de las historias orales temáticas de 6 enfermeras que actuaron en la línea de frente en las ciudades de Arapiraca y Maceió, estado de Alagoas, Brasil. Las categorías temáticas que se destacaron en el análisis fueron: desvalorización, ausencia de estructura física y recursos para el trabajo, vínculo precario de trabajo y relación entre sobrecarga, ponerse enfermo y desgaste. Se constató que esas categorías componen lo que se ha denominado de precarización del trabajo, ya establecida anteriormente, pero amplificada en la pandemia, a ejemplo de la experiencia de las trabajadoras de enfermería.

The experience of working in the confrontation of Covid-19, amid tension, contradictions and impacts in the workers’ health constitutes the context of this research, with the objective of understanding the nursing work in the experience of frontline nurses against Covid-19, in Alagoas, Brazil. This is a qualitative research, using content analysis of the thematic oral histories of 6 nurses, who worked on the frontline in the cities of Arapiraca and Maceió, state of Alagoas, Brazil. The thematic categories emerging from the analysis were: devaluation; lack of physical structure and resources for work; precarious work bond; and the relationship between overload, illness, and wear and tear. It was found that these categories are encompassed by the term work precarization, previously established, but amplified in the pandemic, following the experience of nursing workers.

https://doi.org/10.1590/interface.230021

12.

Documentando histórias: a carreira profissional de Milton Carlos Mariotti a partir do método da história de vida
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Mariotti, Milton Carlos

; Simonelli, Angela Paula

; Cruz, Daniel Marinho Cezar da

; Fedeger, Andrea Maria

; Macedo, Mônica

Cadernos Brasileiros de Terapia Ocupacional

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2023, Volume 31 elocation e3343

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Understanding the history of occupational therapy in Brazil through individual and collective trajectories is fundamental, both for the advancement of knowledge production and for professional training and development in the field. This article is based on the life story of Milton Carlos Mariotti, occupational therapist, Senior Professor at the Federal University of Paraná (UFPR). The objective is to document his professional narrative, the legacy of his leadership and his ethical commitment to the development of occupational therapy in Brazil. For that, four occupational therapist professors got together to formulate a semi-structured interview script composed of 34 questions. Based on the responses, the text was organized into four thematic axes: 1) Educational background, 2) Work as an occupational therapist, 3) Academic trajectory and 4) Political militancy. As a result, a historical narrative is presented that documents the history of the teacher's professional life and his contribution to the institutionalization of occupational therapy in the State of Paraná, southern Brazil.

Resumo Compreender a história da terapia ocupacional no Brasil por meio das trajetórias individuais e coletivas é fundamental, tanto para o avanço da produção de conhecimentos quanto para a formação e desenvolvimento profissional no campo. Este artigo baseia-se na história de vida de Milton Carlos Mariotti, terapeuta ocupacional, Professor Sênior da Universidade Federal do Paraná (UFPR). Objetiva-se documentar sua narrativa profissional, o legado de sua liderança e seu compromisso ético com o desenvolvimento da profissão terapia ocupacional no Brasil. Para tanto, quatro docentes terapeutas ocupacionais reuniram-se para formular um roteiro de entrevista semiestruturada composto por 34 questões. A partir das respostas, organizou-se o texto em quatro eixos temáticos: 1) Formação acadêmica, 2) Atuação como terapeuta ocupacional, 3) Trajetória acadêmica e 4) Militância política. Apresenta-se como resultado uma narrativa histórica que documenta a história de vida profissional do professor e sua contribuição para a institucionalização da terapia ocupacional no Estado do Paraná, Sul do Brasil.

https://doi.org/10.1590/2526-8910.ctoao256333431

13.

Influence of harvest method on proximate composition, texture profile and protein oxidation of beef from grain-fed Nellore cattle
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Salim, Ana Paula Amaral de Alcântara

; Suman, Surendranath Premakumari

; Viana, Fernanda Medeiros

; Canto, Anna Carolina Vilhena da Cruz Silva

; Monteiro, Maria Lucia Guerra

; Adam Conte-Junior, Carlos

; Mano, Sérgio Borges

Acta Scientiarum. Animal Sciences

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2023, Volume 45 elocation e59110

Abstract: En | Text: En | PDF: En

ABSTRACT. The influence of harvest method on proximate composition, protein oxidation, and texture profile of beef from Nellore cattle were investigated. Longissimus lumborum (LL) muscles were obtained from twelve grain-fed Nellore carcasses. The animals were slaughtered after stunning (STU; n=6) or without stunning (WST; n=6) and after 24 hours postmortem, the LL was sliced into 2.54-cm steaks, packed under aerobic conditions, and stored at 4°C for nine days. Proximate composition was analyzed on day 0, whereas protein oxidation (carbonyl content) and texture profile (hardness, chewiness, cohesiveness, and springiness) were evaluated on days 0, 3, 6, and 9. STU and WST steaks exhibited similar proximate composition, hardness, and chewiness (p > 0.05). WST steaks exhibited greater protein oxidation and lower cohesiveness than their STU counterparts on day 0 (p < 0.05). Concerning the storage period, WST steaks demonstrated a decrease in springiness and a more pronounced increase in cohesiveness than their STU counterparts (p < 0.05). These results indicated that the harvest method influenced LL protein oxidation and texture profile from Bos indicus cattle.

https://doi.org/10.4025/actascianimsci.v45i1.59110

14.

National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas

; França, Ana Paula

; Guibu, Ione Aquemi

; Vasconcellos, Maurício Teixeira Leite de

; Moraes, José Cássio de

; Teixeira, Maria da Gloria Lima Cruz

; Domingues, Carla Magda Alan

; Borges, Maria Fernanda de Souza Oliveira

; de Azevedo, Roberta Nogueira Calandrini

; de Oliveira, Consuelo Silva

; Oliveira, Andrea de Nazaré Marvão

; Canales, Ivy Thereza

; Nascimento, Valdir

; Queiroz, Rejane Christine de Souza

; Lima, Luísa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Barbosa, Jaqueline Caracas

; Mirabal, Isabelle Ribeiro Barbosa

; Meira, Meiruska

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria Denise de Castro

; Gurgel, Ricardo Queiroz

; de Carvalho, Martha Suely Itaparica

; Cesar, Tayñana

; Maciel, Ethel Leonor Noia

; da Gama, Silvana Granado Nogueira

; Luhm, Karin Regina

; Boing, Antônio Fernando

; Mengue, Sotero Serrate

; de Oliveira, Sandra Maria do Valle Leone

; Lima, Jaqueline Costa

; Teles, Sheila Araújo

; Caetano, Karlla Antonieta Amorim

; de Araújo, Wildo Navegantes

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230031

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720230031

15.

O trabalho de Enfermagem a partir da experiência de enfermeiras da linha de frente contra Covid-19: na trilha da precarização
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Souza, Diego de Oliveira

; Santos, Maria Leticia Cavalcante

; Santos, Emanuelle Pereira de Araújo

; Magalhães, Ana Paula Nogueira de

; Cruz, Sabrina Ângela França da Silva

Interface - Comunicação, Saúde, Educação

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2023, Volume 27 elocation e230021

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/interface.230021

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