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Global research trends related to coronavirus disease 2019 and the aged: a bibliometric analysis
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Carvalho, Ana Raquel Batista de

; Sousa Neto, Antonio Rosa de

; Silva, Márcia Daiane Ferreira da

; Freitas, Daniela Reis Joaquim de

; Moura, Maria Eliete Batista

Sao Paulo Medical Journal

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2024, Volume 142 N. 2 elocation e2022662

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: A bibliometric analysis covering only the production of original studies or considering world production until 2022 has yet to be conducted. The creation and advancement of vaccines have also influenced research priorities, demonstrating the need for a new approach to this subject. OBJECTIVES: To analyze worldwide scientific production related to coronavirus disease 2019 (COVID-19) and the aged and to describe what has already been produced. DESIGN AND SETTING: Bibliometric analysis with a quantitative approach. METHOD: The search terms “COVID-19,” “SARS-CoV-2,” “Aged,” and “Elderly” were used to retrieve articles from the Web of Science database. A total of 684 articles were included in the analysis. Data were imported into RStudio Desktop Software and linked to R Software. The Bibliometrix R package and VOSviewer software were used for analysis. RESULTS: Most articles were published in 2020. These were produced by 4,937 authors and published in 379 journals. The keyword most used by the authors was “COVID-19.” Publications from 77 countries were obtained. China had the highest article production ranking, and Spain collaborated the most. The articles addressed the implications of the pandemic on the aged, the relationship between vaccination in the aged, and the implications for the disease itself. CONCLUSION: Further research should be conducted, mainly concerning vaccines and vaccination of the aged, owing to the need for and importance of immunization in this risk group, including assessing the long-term effects of vaccines.

https://doi.org/10.1590/1516-3180.2022.0662.r1.190523

REDGIM COMO APLICATIVO DE SMARTPHONE PARA APLICAÇÕES QUIMIOMÉTRICAS POR MEIO DE ANÁLISE DE IMAGENS: UM USO EM PLS
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Rosa, Thalles R.

; Siqueira, Bruno M. M.

; Costa, Rayana A.

; Reis, Jadson Z. dos

; Pacheco, Wagner L. S.

; Moura, Paulo R. G. de

; Romão, Wanderson

; Filgueiras, Paulo R.

Química Nova

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may 2022, Volume 45 N. 5 Pages 550 - 559

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The study of the spectrum of light has increased its range of action in the field of chemistry, with the help of several advanced equipment and innovative techniques that have become a strong ally of analytical chemistry. However, the simplicity of obtaining results integrated with mobile devices appears as an interesting path to be taken in the field of chemical analysis. This work addresses the dissemination of an application called REDGIM for smartphones on the Android platform capable of working with multivariate image analysis using chemometric methods through the luminous intensities of photos and R (red), G (green) and B (blue) channels. In order to show the potential of REDGIM, we propose two applications using the partial least squares (PLS) regression method: 1) quantification of free chlorine in tap water; and 2) quantification of cannabinol, (CBN, a type of cannabinoid) in marijuana and hashish samples. The free chlorine concentration obtained for two investigated samples was 0.73 and 0.74 mg L-1 and 0.74 and 0.76 mg L-1 by the spectrophotometer and by the application (container: cuvette), respectively. For the quantification of CBN in marijuana and hashish samples, the mean concentration ranged from 6.137 to 8.823 mg mL-1. The results obtained by the application are compatible with results from traditional techniques, such as UV-Vis spectrophotometry, for example. Therefore, REDGIM was proved to be a simple and accessible technological tool for the scientific community, being viable for chemical tests of a multivariate nature.

https://doi.org/10.21577/0100-4042.20170861

Proportion of parental line (A receptor and R pollinator) seeds improving rice hybrid production
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Nascente, Adriano Stephan

; Fagundes, Paulo Ricardo Reis

; Mondo, Vitor Henrique Vaz

; Lacerda, Mabio Chrisley

Acta Scientiarum. Agronomy

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2021, Volume 43 elocation e46269

Abstract: En | Text: En | PDF: En

ABSTRACT. The high price of rice hybrid seeds is one of the major limiting factors for increasing the use of this technology. An important step toward minimizing high rice hybrid seed cost is developing techniques that help improve hybrid seed yield. Our goal was to determine the proportion of seeds of line A (receptor) and line R (pollinator) that, under mixed sowing, would allow optimized rice hybrid seed production and grain quality. Trials were performed for two growing seasons in the southern region of Brazil. The cultivar INTA Puita was used as a pollinator and line 464 A as receptor. The experimental design was a randomized block with four replications. Treatments included six proportions of seeds of the INTA Puita (0.75, 1.5, 3.0, 6.0, 12.0, and 24.00%) mixture with seeds of line 464 A (99.25, 98.50, 97.00, 94.00, 88.00, and 76%, respectively). By increasing the percentage of the pollinator seeds (INTA Puita CL) from 0.75 to 24% in the mixture with the receptor (line 464 A), we increased yield of INTA Puita CL grains (7 to 2676 kg ha-1) and hybrid seeds (279 to 1493 kg ha-1). The mixture of different proportions of INTA Puita CL (pollinator) with the receptor (line 464 A) did not change the rice grain quality or the production cost. The cost of production per kg of hybrid seeds decreased quadratically with the increasing percentage of the pollinator (INTA Puita CL), from US$ 6.71 to US$ 1.23. Revenue achieved from the commercialization of the grains of INTA Puita CL with hybrid seeds 464 A showed quadratic increases with the increased percentage of INTA Puita cl in the mixture. Our results showed a potential technique that could be used to improve hybrid seed production, reduce cost per kg of hybrid seed and improve revenue from producing rice hybrid seeds.

https://doi.org/10.4025/actasciagron.v43i1.46269 501 downloads

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

Comparison of methods to determine the lactate threshold during leg press exercise in long-distance runners
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Campos, Yuri

; Vianna, Jeferson

; Guimarães, Miller

; Domínguez, Raúl

; Azevedo, Paulo Henrique

; Ana, Leandro Sant'

; Leitão, Luís

; Novaes, Jefferson

; Silva, Sandro

; Reis, Victor

Motriz: Revista de Educação Física

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2020, Volume 26 N. 2 elocation e10200207

Abstract: En | Text: En | PDF: En

Abstract Aims: To determine lactate threshold (LT) by three different methods (visual inspection, algorithmic adjustment, and Dmax) during an incremental protocol performed in the leg press 45° and to evaluate correlation and agreement among these different methods. Methods: Twenty male long-distance runners participated in this study. Firstly, participants performed the dynamic force tests in one-repetition maximum (1RM). In the next session, completed an incremental protocol consisted of progressive stages of 1 min or 20 repetitions with increments of 10, 20, 25, 30, 35, and 40% 1RM. From 40% 1RM, increments corresponding to 10% 1RM were performed until a load in which the participants could not complete the 20 repetitions. A rest interval of 2 min was observed between each stage for blood collection and adjustment of the workloads for the next stage. Results: Our results showed no significant difference in relative load (% 1RM), good correlations, and high intraclass correlation coefficients (ICC) between algorithmic adjustment and Dmax (p = 0.680, r = 0.92; ICC = 0.959), algorithmic adjustment and visual inspection (p = 0.266, r = 0.91; ICC = 0.948), and Dmax and visual inspection (p = 1.000, r = 0.88; ICC = 0.940). In addition, the Bland-Altman plot and linear regression showed agreement between algorithmic adjustment and Dmax (r2 = 0.855), algorithmic adjustment and visual inspection (r2 = 0.834), and Dmax and visual inspection (r2 = 0.781). Conclusion: The good correlation and high agreement among three methods suggest their applicability to determine LT during an incremental protocol performed in the leg press 45°. However, the best agreement found between mathematical methods suggests better accuracy.

https://doi.org/10.1590/s1980-6574202000020207 614 downloads

Uso do Arduíno como um sistema alternativo para medir radiação solar global e práticas educacionais
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Alves, Péricles Vale

; Reis, Luis Henrique Souza

; Querino, Carlos Alexandre S.

; Moura, Marcos Antônio Lima

; Feitosa Júnior, Adalcir Araújo

; Martins, Paulo André da Silva

Revista Brasileira de Ensino de Física

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2020, Volume 42 elocation e20190304

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Quantificar a intensidade da radiação solar incidente na superfície terrestre é extremamente importante, pois os processos de ordem natural, sejam eles físicos, químicos e/ou biológicos dependem diretamente dela. Contudo, existem algumas dificuldades para medir esta variável, na qual destaca-se o custo elevado de equipamentos para esta finalidade. Desta forma, o objetivo deste trabalho foi desenvolver um protótipo de baixo custo para medir radiação solar global bem como promover a contextualização do ensino de física. Uma estrutura de alumínio fundido, para minimizar os efeitos térmicos e as intempéries sobre suas medidas foi desenvolvida. Esta estrutura era coberta com um difusor plano de acrílico e uma cúpula semi-esférica de vidro que envolvia o sensor fotoresistivo. O protótipo foi conectado ao arduino, usado como datalogger, através de um cabo de rede. Para a calibração do protótipo foi utilizado um piranômetro comercial modelo CM5 da KIPP & ZONEN. Índices estatísticos para se medir a acurácia do protótipo foram aplicados. As medidas foram realizadas continuamente, a cada minuto, durante cinco dias. Os resultados mostraram: coeficiente de determinação foi de R 2 = 0 , 957, de eficiência ( ε = 0 , 95 ), índice de concordância de Willmott ( d = 0 , 99 ) e o erro médio absoluto ( E M A = 51 , 22 W m − 2 ). Verifica-se uma boa aproximação dos valores de radiação solar global medidas pelo protótipo referentes aos do CM5. Portanto, a construção deste protótipo é útil para facilitar e difundir medidas diárias de radiação solar global e, sobre tudo, poderá contribuir com a contextualização dos conceitos estudados em Física nos ensinos básico e superior.

Abstract Quantifying the intensity of the incoming solar radiation at the earth's surface is important, to the natural, physical, chemical and / or biological processes. However, there are some difficulties in measuring this variable, due to the high cost of equipment for this purpose. Thus, the objective of this work was to develop a low cost prototype to measure global solar radiation. A cast aluminum frame, covered with a flat acrylic diffuser and a semi-spherical glass dome, to surround the photoresist sensor and minimize thermal and weather effects on its measurements, was made. The prototype was connected to the arduino, used as datalogger. A commercial KIPP & ZONEN pyranometer model CM5 was used for calibration. Measurement accuracy was determined by determination coefficients ( R 2 = 0.957 ), coefficients of efficiency ( ε = 0.95 ), Willmott agreement index ( d = 0.99 ), and mean absolute error ( M A E = 51.22 W m − 2 ). There is a good approximation of the global solar radiation values measured by the prototype for CM5. Therefore, the construction of this prototype is useful to facilitate and diffuse daily measurements of global solar radiation and, overall, may contribute to the contextualization of the concepts studied in physics in the highschool and colege education.

https://doi.org/10.1590/1806-9126-rbef-2019-0304 2238 downloads

Sleep and glycemic control in type 1 diabetes
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Barone, Mark Thomaz Ugliara

; Wey, Daniela

; Schorr, Fabiola

; Franco, Denise Reis

; Carra, Mario Kehdi

; Lorenzi Filho, Geraldo

; Menna-Barreto, Luiz

Archives of Endocrinology and Metabolism

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feb 2015, Volume 59 N. 1 Pages 71 - 78

Abstract: En | Text: En | PDF: En

Objective Our aim in the present study was to elucidate how type 1 diabetes mellitus (T1DM) and sleep parameters interact, which was rarely evaluated up to the moment. Materials and methods Eighteen T1DM subjects without chronic complications, and 9 control subjects, matched for age and BMI, were studied. The following instruments used to evaluate sleep: the Epworth Sleepiness Scale, sleep diaries, actimeters, and polysomnography in a Sleep Lab. Glycemic control in T1DM individuals was evaluated through: A1C, home fingertip glucometer for 10 days (concomitant with the sleep diary and actimeter), and CGM or concomitant with continuous glucose monitoring (during the polysomnography night). Results Comparing with the control group, individuals with diabetes presented more pronounced sleep extension from weekdays to weekends than control subjects (p = 0.0303). Among T1DM, glycemic variability (SD) was positively correlated with sleep latency (r = 0.6525, p = 0.0033); full awakening index and arousal index were positively correlated with A1C (r = 0.6544, p = 0.0081; and r = 0.5680, p = 0.0272, respectively); and mean glycemia values were negatively correlated with sleep quality in T1DM individuals with better glycemic control (mean glycemia < 154 mg/dL). Conclusion Our results support the hypothesis of an interaction between sleep parameters and T1DM, where the glycemic control plays an important role. More studies are needed to unveil the mechanisms behind this interaction, which may allow, in the future, clinicians and educators to consider sleep in the effort of regulating glycemic control. Arch Endocrinol Metab. 2015;59(1):71-8

https://doi.org/10.1590/2359-3997000000013 3650 downloads

Modelos de regressão não linear aplicados a grupos de acessos de alho
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Reis, Renata M

; Cecon, Paulo R

; Puiatti, Mário

; Finger, Fernando L

; Nascimento, Moysés

; Silva, Fabyano F

; Carneiro, Antônio PS

; Silva, Anderson R

Horticultura Brasileira

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jun 2014, Volume 32 N. 2 Pages 178 - 183

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O principal objetivo deste estudo foi comparar modelos de regressão não linear aptos a descreverem o acúmulo de massa seca de diferentes partes da planta do alho ao longo do tempo (60, 90, 120 e 150 dias após plantio). Objetivou-se também identificar acessos semelhantes em relação às características avaliadas por meio de análises de agrupamento. Foram utilizados 20 acessos de alho pertencentes ao Banco de Germoplasma de Hortaliças da Universidade Federal de Viçosa (BGH/UFV). O teor de massa seca da folha, do pseudocaule, do bulbo e da raiz foram definidos como variáveis na análise de agrupamento (algoritmo de Ward utilizando como medida de dissimilaridade a distância quadrada generalizada de Mahalanobis), que resultou na indicação de um número ótimo (critério de Mojena) de três grupos de acessos, cujas médias de massa seca do bulbo, da raiz e total da planta em cada tempo de interesse foram utilizadas para o ajuste de cinco modelos de regressão não linear (Mitscherlich, Gompertz, Logístico, Brody e von Bertalanffy). A identificação do modelo que melhor se ajustou às três características de cada grupo foi realizada mediante coeficiente de determinação (R2), o quadrado médio do resíduo (QMR) e o desvio médio absoluto dos resíduos (DMA). Comparando os valores desses avaliadores observou-se que, para as três caraterísticas dos três grupos, o modelo que melhor se ajustou foi o Logístico.

The main objective of this study was to compare nonlinear regression models able to describe the dry matter accumulation in different parts of the garlic plant over time (60, 90, 120 and 150 days after planting). This study also aimed to identify similar accessions with respect to the characteristics evaluated through cluster analysis. We used 20 garlic accessions belonging to the Vegetable Germplasm Bank of Universidade Federal de Viçosa. The dry matter content of leaves, pseudostems, bulbs and roots were defined as variables in the cluster analysis (Ward algorithm using as dissimilarity measure the squared generalized Mahalanobis distance), which resulted in the appointment of an optimal number (Mojena criteria) of three groups of accessions, whose means of dry matter of bulbs, of roots and of the whole plant were used for fitting five nonlinear regression models (Mitscherlich, Gompertz, Logistic, von Bertalanffy and Brody). The identification of the model that best fitted the three characteristics of each group was carried out by coefficient of determination (R²), the error mean square and the average deviation absolut error. Comparing the values of these evaluators, we found that, for the three characteristics of the three groups, the best fitted model was the Logistic.

https://doi.org/10.1590/S0102-05362014000200010 2246 downloads

Equação preditora de idade óssea na iniciação esportiva através de variáveis antropométricas
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Cabral, Breno Guilherme de Araújo T.

; Cabral, Suzet de Araújo Tinôco

; Vital, Roberto

; Lima, Kenio Costa de

; Alcantara, Tabata

; Reis, Victor Machado

; Dantas, Paulo Moreira Silva

Revista Brasileira de Medicina do Esporte

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apr 2013, Volume 19 N. 2 Pages 99 - 103

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: Atualmente o desempenho esportivo tem se desenvolvido de forma rápida e concreta, exigindo, dessa forma, uma eficiente evolução das diferentes áreas das ciências do esporte, oferecendo o suporte cientifico necessário à continuidade desse fenômeno. OBJETIVO: O estudo em questão teve como objetivo desenvolver uma equação matemática preditora de idade óssea de jovens atletas, com base em variáveis antropométricas. MÉTODOS: Para se alcançar o resultado final foram medidas dobras cutâneas, perímetros corporais e diâmetros ósseos, idade cronológica e idade óssea. O tratamento estatístico utilizou a correlação entre as variáveis, a regressão linear múltipla com modelagem backward. RESULTADO: Se obteve como resultado final um modelo de equação que explica 75,4% da variação da idade óssea com r = 0,868 e R² = 0,754, utilizando idade cronológica, estatura, dobra tricipital, perímetro corrigido de braço e diâmetros de fêmur e úmero. CONCLUSÃO: Concluiu-se a partir dos resultados, que esse tipo de modelo revela valores aproximados aos observados através da radiografia de mão e punho, tornando-se importante na observação do estágio maturacional através de testes de fácil aplicabilidade por profissionais da área esportiva.

INTRODUCTION: Currently sports performance has developed rapidly and concrete, thus requiring an efficient evolution of different areas of sport sciences offering scientific support necessary continuity of this phenomenon. OBJETIVE: The present study aimed to develop a predictive mathematical equation bone age of young athletes, based on anthropometric variables. METHODS: To achieve the final result were measured skinfolds, body circumferences and bone diameters, chronological age and bone age. The statistician treatment used the correlation between variables, multiple linear regression model with backward. RESULTS: the study had the end result of a model equation that explaining 75.4% (r = 0,868; R² = 0,754) of the variation of bone age using the chronological age, height, triceps skinfolds, perimeter corrected arm and diameters of femur and humerus. CONCLUSION: It was concluded from the results that this type of model shows approximate values to those observed by the hand and wrist radiography, becomes important in the observation of maturational stage through testing is easily performed by professionals in the sports area.

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Estratégia de troca entre agentes anti-TNF-alfa não melhora a capacidade funcional em pacientes com artrite reumatoide de longa evolução
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Soares, Maria Roberta Melo P

; Reis Neto, Edgard T. dos

; Luz, Karine R

; Ciconelli, Rozana M

; Pinheiro, Marcelo M

Revista Brasileira de Reumatologia

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feb 2012, Volume 52 N. 1 Pages 9 - 15

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Avaliar a resposta clínica após a estratégia de troca entre agentes antifator de necrose tumoral alfa (anti-TNF-alfa) em pacientes com artrite reumatoide (AR). PACIENTES E MÉTODOS: Foram incluídos 99 pacientes com diagnóstico de AR (American College of Rheumatology, 1987), em uso de terapia anti-TNF-alfa, para avaliação da resposta terapêutica após 24 semanas. A estratégia de troca foi feita se, após 12 a 24 semanas, houvesse relato de evento adverso sério (T: toxicidade) ou se não ocorresse redução maior que 0,6 do índice de atividade da doença (DAS28) inicial (RI: resposta inadequada). Nesse último caso, o paciente foi considerado como falência primária (FP). Falência secundária (FS) foi definida se houvesse perda de resposta após melhora inicial. Remissão (DAS28 < 2,6), baixa atividade de doença (2,61 < 3,2) e melhora funcional [aumento > 0,2 do questionário de avaliação da saúde (HAQ) inicial] foram avaliadas por análise de regressão linear. P < 0,05 foi considerado significante. RESULTADOS: A estratégia de troca foi realizada em 39 (39,4%) pacientes, especialmente por FP (24,3%), FS (35,1%) e T (40,5%). A taxa de retenção ao primeiro agente foi de 60,1%, e o tempo médio para a troca foi de 14,2 ± 10,9 meses. Após a troca, houve tendência à queda do DAS28 (4,7 ± 1,4; P = 0,08), mas não do HAQ (1,2 ± 0,77; P = 0,11). Cerca de 43% deles alcançaram boa/moderada resposta EULAR. O principal determinante da troca foi o DAS28 inicial mais elevado, independente de idade, tempo de doença e capacidade funcional. CONCLUSÃO: A estratégia de troca entre agentes anti-TNF-alfa é válida para o controle da atividade de doença, embora com baixa probabilidade de remissão e sem melhora significativa da capacidade funcional

OBJECTIVES: To assess clinical response after switching between anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: This study included 99 patients diagnosed with RA American College of Rheumatology, 1987), on anti-TNF-alpha therapy, to assess the therapeutic response after 24 weeks. Switching was performed if, after 12 to 24 weeks, a severe adverse event was reported (toxicity: T) or if no reduction greater than 0.6 in the initial Disease Activity Score 28 (DAS28) occurred (inadequate response: IR). In case of IR, the patient was considered as primary failure (PF). Secondary failure (SF) was defined as loss of response after initial improvement. Remission (DAS28 < 2.6), low disease activity (between 2.61 and 3.2), and functional improvement [increase in the initial Health Assessment Questionnaire (HAQ) > 0.2] were assessed by use of linear regression analysis. The significance level adopted was P < 0.05. RESULTS: Switching was performed in 39 (39.4%) patients, especially due to PF (24.3%), SF (35.1%) and T (40.5%). The retention rate of the first agent was 60.1%, and the mean time for switching was 14.2 ± 10.9 months. After switching, a tendency towards a decrease in DAS28 was observed (4.7 ± 1.4; P = 0.08), but not in the HAQ (1.2 ± 0.77; P = 0.11). Around 43% of the patients achieved good/moderate EULAR response. The major determinant of switching was a higher initial DAS28, independent of age, duration of disease, and functional capacity. CONCLUSION: Switching between anti-TNF-alpha agents is a valid strategy to control disease activity, despite the low likelihood of remission and no significant improvement in functional capacity

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11.

Influência da teia de Oligonychus ilicis (McGregor) (Acari: Tetranychidae) sobre os fitoseídeos predadores associados
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Franco, Renato A

; Reis, Paulo R

; Zacarias, Mauricio S

; Oliveira, Daniel C

Neotropical Entomology

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feb 2010, Volume 39 N. 1 Pages 97 - 100

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Oligonychus ilicis (McGregor) is among those mite species that can cause damage to coffee plants (Coffea spp.). Species of Phytoseiidae acari are considered the most important and studied predatory mites. The objective of this study was to evaluate the effects of the webbing produced by O.ilicis on its predation by females of the phytoseiids Iphiseiodes zuluagai Denmark & Muma, Euseius citrifolius Denmark & Muma and Amblyseius herbicolus (Chant). Four bioassays were conducted, with three treatments and ten replicates. Each replicate consisted of 25 O.ilicis per experimental unit (a leaf disc of Coffea arabica) according to the tested developmental stage, in independent experiments. To spin the web, 15 adult females were put on each experimental unit for 24h; females were then removed, leaving only the web, and predators and prey to be tested were introduced. Predation was assessed after 24h. In the presence of webbing, the consumption of eggs, larvae and nymphs by I.zuluagai and eggs and larvae by E.citrifolius was lower. For A.herbicolus, egg predation was lower, but larval predation did not vary significantly and predation of nymphs and adults was higher in the presence of webbing. Predators as a whole were more efficient consuming larvae regardless of the presence of webbing. Considering the stages of O.ilicis altogether, webbing reduced the predation potential of I.zuluagai and E. citrifolius, but not of A. herbicolus.

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12.

Desenvolvimento de um modelo para previsão de ocorrência do bicho-furão-dos-citros, Ecdytolopha aurantiana (Lima) (Lepidoptera: Tortricidae
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Reis Jr., Ronaldo

; Parra, José R.P.

; Bento, José M.S.

Neotropical Entomology

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aug 2005, Volume 34 N. 4 Pages 627 - 637

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente trabalho teve como objetivo desenvolver um modelo para previsão de ocorrência do bicho-furão-dos-citros, Ecdytolopha aurantiana (Lima). Para tanto, 553 áreas localizadas em 17 fazendas do estado de São Paulo foram monitoradas por meio de armadilhas com feromônio sexual de E. aurantiana durante um ano. O tipo de solo, temperatura mensal média do local, variedade de citros, idade das plantas e uso de agroquímicos para o controle de E. aurantiana, foram utilizados como variáveis para cada área mencionada. A maior influência sobre a flutuação populacional do bicho-furão-dos-citros foi exercida pelo tipo de solo, seguido pela temperatura mensal média do local, variedade de citros, idade das plantas e uso de agroquímicos. A ocorrência de E. aurantiana em função da temperatura foi diferente para cada combinação de tipo de solo, variedade de citros, idade das plantas e uso de agroquímicos. O modelo desenvolvido pode prever o potencial de ocorrência de E. aurantiana em função da temperatura ou dos meses do ano, levando-se em consideração o tipo de solo, variedade de citros, idade das plantas e aplicação de agroquímicos. O programa (BF) elaborado na linguagem R conta com equações para simular as diversas situações de ocorrência de E. aurantiana. O modelo de previsão de ocorrência de bicho-furão pode ser aperfeiçoado com a coleta de dados mais regulares e de forma contínua.

The goal of this work was to develop a model to predict the occurrence of Ecdytolopha aurantiana (Lima), based on monitoring data collected through sexual pheromone traps. Soil type, site temperature, citrus variety, age of plants and use of chemicals to control E. aurantiana influenced the population dynamics of the insect. The highest influence was exerted by the soil type, followed by site temperature, citrus variety, age of plants and the use of chemicals for E. aurantiana control. The occurrence of E. aurantiana according to temperature is different for each combination of soil type, citrus variety, age of plants and use of chemicals. The model developed can predict the occurrence potential of E. aurantiana according to temperature or months of the year, taking into account soil type, citrus variety, age of plants and chemicals spraying. The elaborated software (BF), designed in R language, includes equations that simulate the various situations of E. aurantiana occurrence. The predicting model of citrus fruit borer occurrence can be improved with more frequent and continuous data collecting.

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13.

Análise da confiabilidade do método Figura Oito e da volumetria para mensuração do edema de tornozelo
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Reis, Filipe Abdalla dos

; Ribeiro, Eduardo Alves

; Carvalho, Paulo de Tarso Camillo de

; Belchior, Ana Carulina Guimarães

; Arakaki, Juliano Coelho

; Vasconcelos, Rodrigo Antunes de

Revista Brasileira de Medicina do Esporte

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dec 2004, Volume 10 N. 6 Pages 468 - 471

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A presença de lesões no tornozelo torna necessária a mensuração do edema como fator diagnóstico e evolutivo. O presente trabalho teve como objetivo analisar a confiabilidade do método Figura Oito e da volumetria para a mensuração do volume do tornozelo, intrateste e interteste. Vinte voluntários, sexo masculino, assintomáticos, idade entre 15 e 30 anos (X= 21,8), foram avaliados aleatoriamente por três examinadores; cada um realizou três mensurações utilizando o método Figura Oito e três, a volumetria. A ordem dos examinadores e da técnica de mensuração foi aleatória. Observou-se excelente confiabilidade nas duas técnicas (ICC = 0,99). O coeficiente de correlação momento-produto de Pearson demonstrou similaridade entre os examinadores; o primeiro apresentou r = 0,91, o segundo, r = 0,95 e o terceiro, r = 0,96. Concluiu-se que os dois métodos são confiáveis, apesar de a maioria dos autores recomendar o método Figura Oito pela sua praticidade, rapidez e baixo custo.

Edema's measurements on ankle injuries are necessary as part of the evaluation and diagnostic check. The present study was designed to analyze the Figure-of-Eight method and volumetry measurements and check their intratest and intertest reliability. Twenty asymptomatic healthy male volunteers from 15 to 30 years of age, were randomly examined by three clinical examiners. Each examiner performed three measurements following each method. It was used standardized positioning and measurement techniques. The results showed reliability in both methods (ICC = 0.99). The Pearson product-moment correlation coefficients showed reproduction between examiners, where values of r = 0.91, r = 0.95 and r = 0.96, respectively were found. These findings suggest the Figure-of-Eight method and volumetry are reliable measurements.

La presencia de lesiones del tobillo hace necesario el medir la magnitud del edema como factor diagnóstico y evolutivo. El presente trabajo tiene como objetivo analisar la confiabilidad del metodo Figura Ocho y de la volumetría para la mensura del volumen del tobillo intratest e interteste. Veinte voluntarios, de sexo masculino, asintomáticos, de edades entre 15 a 30 años (X= 21.8), fueron avaluados aleatoriamente por tres examinadores, donde cada uno realizó tres medidas utilizando el método Figura Ocho y tres utilizando la volumetria. La orden de los examinadores y de la técnica de mensura fué aleatoria. Se ha observado una excelente confiabilidad en las dos técnicas (ICC = 0.99). El coeficiente de correlación momento-produto de Pearson demonstró similaridad entre los examinadores, siendo que el primero presentó r = 0.91, el segundo r = 0.95 y el tercero r = 0.96. Se concluye que los dos métodos son confiables, a pesar de la mayoría de los autores han recomendado el método Figura Ocho por su practicidade, rapidez e bajo costo.

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14.

Desenvolvimento de um projeto para construção de bomba-balão para contrapulsação aórtica
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Reis, Celso Luiz dos

; Évora, Paulo Roberto Barbosa

; Brasil, José Carlos Franco

; Ribeiro, Paulo José de Freitas

; Otaviano, Adonis Garcia

; Bongiovani, Hércules Lisboa

; Bombonato, Rúbio

; Ferez, Marcus Antônio

; Sgarbieri, Ricardo Nilsson

; Moreira Neto, Francisco Fernandes

; Pereira, Almir Sales

; Gomes, Percival

Brazilian Journal of Cardiovascular Surgery

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dec 1989, Volume 4 N. 3 Pages 210 - 219

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente trabalho tem por finalidade apresentar as etapas de um projeto para construção de uma bomba-balâo para contrapulsação aórtica. Desenvolveram-se três protótipos, sendo que os dois primeiros utilizavam ar comprimido e vácuo hospitalares para insuflação e deflação do cateter-balão. Esses dois protótipos apresentavam como diferenças fundamentais: o tipo de dispositivo que captava o sinal luminoso da onda R do ECG utilizado para a sincronização do bombeamento; o tipo de válvula solenóide e os componentes eletrônicos de maior resolução utilizados no segundo protótipo. O terceiro e atual protótipo passou a obter o sinal da onda R diretamente da saída de cardioversão do monitor de ECG e substituiu o ar comprimió e o vácuo hospitalares, além das válvulas solenóides, por uma bomba eletromagnética. Está em fase de resolução o problema de deflação tardia que ainda ocorre no sistema.

The present paper presents the project and construction of a balloon-pump for aortic counterpulsation. Three experimental models were developed, the first two using hospital air and vacuum lines for inflation and deflation of the balloon catheter. These two inicial models diffères among themselves in the mechanism used to capture the light signal corresponding to the R wave of the ECG, which was used to sincronize the pumping. The solenoid valve and electronic components were of higher resolution in the second model. The third and present model recieves the R wave signal from the cardioversor adaptor of ECG monitor and the hospital vacuum and air lines along with the solenoid valve were substituted by an electromagnetic pump. The problems related to late deflation that have ocurred in the system are still in study. Emphasis is given on the importance of this research, which has incremented knowledge for the construction of other medical equipment, mainly in the area of respiratory care.

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