Abstract A fibrinolytic enzyme from the microalga Dunaliella tertiolecta was produced under mixotrophic conditions using different corn steep liquor (CSL) concentrations ( 0 ≤ CLS ≤ 0.75%), purified using a combination of salting out and ion-exchange chromatography, and then biochemical characterized. Cultivation of this microalga using 0.5% CSL led to the highest maximum cell concentration (1.960±0.010 mg L-1) and cell productivity (0.140g L-1 day-1), besides a high fibrinolytic activity of the extract obtained by the homogenization method (102 ±1 U mL-1). The enzyme extracted from the microalgal biomass was 5-fold purified with a 20% yield and was found to have a specific activity of 670 U mg-1. The enzyme, whose molecular weight determined by fibrin zymography was 10 kDa, was shown to be stable at pH 3.0–9.0 and up to 70°C with optimal pH and temperature values of 8.0 and 50°C, respectively. When compared to other fibrinolytic enzymes, this protease stood out for its high fibrinolytic activity, which was enhanced by Fe2+, inhibited by Zn2+, Cu2+, Mg2+, and Ca2+, and strongly inhibited by phenylmethylsulfonyl fluoride, suggesting that it belongs to the serine metalloprotease family. Moreover, thanks to its thermal stability, the enzyme may be easily preserved and activated under high-temperature conditions.

ABSTRACT The presence of desiccation cracks in the soil alters its hydromechanical behavior, increasing the soil's water infiltration capacity, mobilizing the potential for expansion. This may affect the performance of the structural elements of the construction. This study aimed to evaluate the mechanics of expansion, contraction and cracking of the expansive soil of Paulista - Pernambuco, Brazil, through field trials, subject to wetting cycles and drying. The studied soil is a sandy silty clay of high compressibility with medium to very high expansion potential. The process of formation and propagation of cracks was analyzed using digital images and the monitoring of samples subjected to drying and wetting cycles. The indices of crack geometry increased with the advancement of desiccation but did not stabilize. During the wetting period, they tend to close. The pattern of cracks in the tests varied according to the presence or absence of vegetation. It was concluded that the vegetation cover has a significant influence on the standardization and the crack formation and propagation process.

Resumo Objetivos: analisar aspectos epidemiológicos e clínicos dos acidentes por animais peçonhentos em menores de 15 anos. Métodos: estudo transversal com componente analítico utilizando dados secundários do Centro de Informação e Assistência Toxicológica de Pernambuco (CIATox-PE), no período de 2017 a 2019. Foram incluídas as notificações dos acidentes na faixa etária estudada e avaliadas características do envenenamento (classe do animal, zona de exposição, local/turno da ocorrência e uso soroterapia específica) e do paciente (variáveis sociodemográficas, gravidade clínica e evolução). A análise realizada no STATA® 13.1 apresenta tabelas de distribuição de frequência e qui-quadrado de Pearson para comparação. Resultados: das 2678 notificações, 82,8% foram de escorpionismo e 10,8% de ofidismo. Predominaram na faixa etária de 1a 9 anos (70,5%) e sexo masculino (54,1%);ocorreram principalmente na zona urbana (80,9%),no Recife(67,3%), na residência da vítima (83,9%), durante horário noturno (47,3%). A maioria (87,1%) foi classificada como de gravidade leve, 10% receberam soroterapia e ocorreu um óbito (escorpionismo). Registraram-se dois casos de ofidismo em ambiente de trabalho. Conclusão: ressaltam-se os acidentes intradomiciliares entre crianças e a suspeita de trabalho infantil na faixa etária de 10 a 14anos.Os acidentes ocorreram sobretudo na zona urbana provavelmente associado à falta de planejamento e educação sanitária que favorece o desenvolvimento e hábitos do animal peçonhento.

Abstract Objectives: to analyze the epidemiological and clinical aspects of accidents caused by venomous animals in children under 15 years old. Methods: a cross-sectional study with an analytical component using secondary data from Centro de Informação e Assistência Toxicológica de Pernambuco (CIATox-PE), (Poison Center in Pernambuco)), in 2017 to 2019. Notifications of accidents caused were included in the studied age group and evaluated the characteristics of poisoning (animal classification, exposure zone, place and time of the occurrence and specific use of serum therapy), and of the patient (sociodemographic variables, clinical condition and evolution). The analysis performed in STATA® 13.1 presents frequency distribution tables and Pearson’s chi-square for comparison. Results: of the 2678 notifications, 82,8% were scorpionism and 10, 8% snakebite. The age group of1 to 9 years old (70.5%) and being male (54.1%) were predominant. Most of the cases occurred in urban area (80.9%), in Recife (67.3%), inside the victim’s residence (83.9%) and at night (47.3%). The majority (87.1%) were classified as ‘mild severity’, 10% received antivenom therapy and one died (by scorpionism). Two cases of snakebite in the workplace were registered. Conclusion: there was a high frequency of accidents caused in the urban area, which may be related to the lack of urban planning and sanitary education. The accidents caused among children in the household environment and the suspicion of child labor in the age group of 10 to 14 years old were also highlighted which favors the development and habits of the venomous animal.

Abstract Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to the hypertension treatment. The algae have been an alternative for the production of ACE inhibitory (ACEi) peptides from enzymatic hydrolysis due to their protein-rich biomass. The aim of this study was to systematically review the literature regarding the production, composition and activity of ACEi peptides derived from algae proteins. Systematic database searches identified 648 related articles. Among these, only 14 were selected according to the eligibility criteria to this review. Macroalgae are more studied than microalgae as sources of ACEi peptides. Furthermore, hydrolysates by thermolysin or bromelain exhibited the highest ACEi activity compared to other enzymes. The main features of the peptides with high ACE inhibition are low molecular weight, short amino acids sequence and non-competitive inhibition pattern. In vivo studies using hydrolysates and peptides derived from algae proteins showed antihypertensive activity in spontaneously hypertensive rats (SHR). Thus, it is suggested that ACEi peptides derived from algae can be considered as potential antihypertensive.

Resumo Os temas sífilis congênita e criança exposta à sífilis compõem o Protocolo Clínico e Diretrizes Terapêuticas para Atenção Integral às Pessoas com Infecções Sexualmente Transmissíveis, publicado pelo Ministério da Saúde do Brasil em 2020. Tal documento foi elaborado com base em evidências científicas e validado em discussões com especialistas. Este artigo apresenta orientações para o manejo clínico da sífilis em gestantes e da sífilis congênita, enfatizando a prevenção da transmissão vertical do Treponema pallidum. Nele estão contemplados aspectos epidemiológicos e clínicos desses agravos, bem como recomendações aos gestores no manejo programático e operacional da sífilis. Também se incluem orientações para os profissionais de saúde na triagem, diagnóstico e tratamento das pessoas com infecções sexualmente transmissíveis e suas parcerias sexuais, além de estratégias para ações de vigilância, prevenção e controle da doença.

Abstract The topics of congenital syphilis and children exposed to syphilis are part of the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. The Protocol and Guidelines have been developed based on scientific evidence and validated in discussions with specialists. This article provides guidelines for clinical management of both syphilis in pregnant women and also congenital syphilis, emphasizing prevention of vertical transmission of Treponema pallidum. Epidemiological and clinical aspects of these infections are presented, as well as recommendations for health service managers regarding the programmatic and operational management of syphilis. The article also includes guidelines for health professionals on screening, diagnosing and treating people with sexually transmitted infections and their sex partners, in addition to strategies for syphilis surveillance, prevention and control actions.

Resumen Los temas sífilis congénita y niños expuestos a la sífilis componen el Protocolo Clínico y Directrices Terapéuticas para la Atención Integral a Personas con Infecciones de Transmisión Sexual, publicado por el Ministerio de Salud de Brasil en 2020. Tal documento fue elaborado con base en evidencia científica y validado en discusiones con especialistas. Este artículo presenta directrices para el manejo clínico de la sífilis en mujeres embarazadas y de la sífilis congénita, con énfasis en la prevención de la transmisión vertical del Treponema pallidum. Se contemplan aspectos epidemiológicos y clínicos de la infección, así como recomendaciones para gestores en la gestión programática y operativa de la sífilis. También se incluyen directrices para profesionales de la salud en la detección, diagnóstico y tratamiento de personas con infecciones de transmisión sexual y sus parejas sexuales, además de estrategias para acciones de vigilancia, prevención y control de la enfermedad.

Resumo Os temas sífilis congênita e criança exposta à sífilis compõem o Protocolo Clínico e Diretrizes Terapêuticas para Atenção Integral às Pessoas com Infecções Sexualmente Transmissíveis, publicado pelo Ministério da Saúde do Brasil em 2020. Tal documento foi elaborado com base em evidências científicas e validado em discussões com especialistas. Este artigo apresenta orientações para o manejo clínico da sífilis em gestantes e da sífilis congênita, enfatizando a prevenção da transmissão vertical do Treponema pallidum. Nele estão contemplados aspectos epidemiológicos e clínicos desses agravos, bem como recomendações aos gestores no manejo programático e operacional da sífilis. Também se incluem orientações para os profissionais de saúde na triagem, diagnóstico e tratamento das pessoas com infecções sexualmente transmissíveis e suas parcerias sexuais, além de estratégias para ações de vigilância, prevenção e controle da doença.

Resumen Los temas sífilis congénita y niños expuestos a la sífilis componen el Protocolo Clínico y Directrices Terapéuticas para la Atención Integral a Personas con Infecciones de Transmisión Sexual, publicado por el Ministerio de Salud de Brasil en 2020. Tal documento fue elaborado con base en evidencia científica y validado en discusiones con especialistas. Este artículo presenta directrices para el manejo clínico de la sífilis en mujeres embarazadas y de la sífilis congénita, con énfasis en la prevención de la transmisión vertical del Treponema pallidum. Se contemplan aspectos epidemiológicos y clínicos de la infección, así como recomendaciones para gestores en la gestión programática y operativa de la sífilis. También se incluyen directrices para profesionales de la salud en la detección, diagnóstico y tratamiento de personas con infecciones de transmisión sexual y sus parejas sexuales, además de estrategias para acciones de vigilancia, prevención y control de la enfermedad.

Abstract The topics of congenital syphilis and children exposed to syphilis are part of the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. The Protocol and Guidelines have been developed based on scientific evidence and validated in discussions with specialists. This article provides guidelines for clinical management of both syphilis in pregnant women and also congenital syphilis, emphasizing prevention of vertical transmission of Treponema pallidum. Epidemiological and clinical aspects of these infections are presented, as well as recommendations for health service managers regarding the programmatic and operational management of syphilis. The article also includes guidelines for health professionals on screening, diagnosing and treating people with sexually transmitted infections and their sex partners, in addition to strategies for syphilis surveillance, prevention and control actions.

Abstract The topics of congenital syphilis and children exposed to syphilis compose the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. Such document was elaborated based on scientific evidence and validated in discussions with specialists. This article provides guidelines for syphilis in pregnant women and congenital syphilis clinical management, emphasizing the vertical transmission of Treponema pallidum prevention. Epidemiological and clinical aspects of these infections are presented and recommendations for managers in the programmatic and operational management of syphilis. The article also includes guidelines for health professionals in screening, diagnosing, and treating people with sexually transmitted infections and their sex partners, in addition to strategies for surveillance actions, prevention, and control of the disease.

ABSTRACT Expansive clay soils are a problem for agriculture and engineering because they are susceptible to change in volume due to seasonal variation in water content and temperature. One of its morphological properties is slickensides, which result from the ability to contract and crack when dry and expand by wetting. The objective of this study was to evaluate the processes of expansion and formation and propagation of cracks due to the change in water content over time. The expansion process was evaluated through simple edometric tests with different external stress values applied to undisturbed soil samples. To evaluate the shrinking process, a device was developed to monitor the process of crack propagation. The mechanisms through which cracks begin and develop were studied using molded soil samples at the liquidity limit and at 1.25 times the liquidity limit with a drying and wetting cycle. Crack initiation conditions and development of geometric crack indices were measured with the water content and drying time. The soil presented medium to high expansion that depends on the overburden and suction applied, and the swelling stress was found to increase as suction increases. The changes in volume due to wetting and the propagation of cracks due to drying developed in three stages: initial, primary, and secondary. In the initial stage, few cracks or swelling occur with gradual variation in water content. As the water content approaches the limit of soil contraction (in the drying process) or the limit of soil saturation (in the wetting process), cracks and expansion developed slowly and approach a secondary stage. In the primary stage, cracks and expansion occurred rapidly with drying or wetting, respectively. Drying and wetting cycles showed similar crack patterns with the appearance of new micro-cracks during each new drying cycle.

Resumo O presente estudo teve como objetivo caracterizar a importância de Anaplasma marginale, Babesia bigemina e Babesia bovis na gênese da tristeza parasitária bovina em bezerros leiteiros do noroeste de Minas Gerais. Foram coletadas 300 amostras sanguíneas de bezerros, seguidas por extração de DNA e Nested- PCR utilizando oligonucleotídeos iniciadores que amplificam fragmentos dos genes sbp-4 (B. bovis) e rap-1a (B. bigemina) e a Semi-Nested para o gene msp5 (A. marginale). A prevalência de A. marginale foi 55,66% (167/300), B. bigemina, 15,33% (46/300) e B. bovis 4,0% (12/300) dos bezerros examinados. Formas parasitárias de A. marginale and B. bigemina foram encontradas em 36,33% e 2,66% dos esfregaços sanguíneos, enquanto B. bovis não foi detectado. Houve diferença estatística entre as prevalências de animais infectados nas faixas etárias 1 (10-70 dias) e 2 (>70-300 dias). Um total de 15 animais com sintomas clássicos da doença foram examinados, e as amostras foram confirmadas como uma infecção simples por A. marginale através da Nested-PCR. Esses resultados confirmam a anaplasmose bovina como a principal agente da tristeza parasitária bovina nos bezerros do rebanho estudado.

Abstract The present study aimed to characterize the importance of the Anaplasma marginale, Babesia bovis and Babesia bigemina in the genesis of cattle tick fever (CTF) among dairy calves in the northwest of Minas Gerais, Brazil. Blood samples from 300 calves were collected, followed by DNA extraction and nested PCR using oligonucleotide primers to amplify fragments of the semi-nested for the msp5 gene (A. marginale), sbp-4 (B. bovis) and rap-1a (B. bigemina) Among the examined calves, the prevalence of A. marginale was 55.6% (n=167/300), B. bovis was 4.0% (n=12/300) and B. bigemina was 15.3% (n=46/300), by PCR techniques. Parasitic forms of A. marginale and B. bigemina were found in 36,3% and 2,6% of the blood smears while B. bovis was not detected. There was a statistical difference between the positivity of infected animals in the age groups 1 (10-70 days) and (>70-300 days) for A. marginale and B. bigemina. A total of 15 calves with the classic symptoms of disease were examined, and the samples obtained were confirmed as a simple infection by A. marginale through semi-nested PCR. These results confirm bovine anaplasmosis as the primary cause of CTF among the calves of dairy cattle within the studied area.

RESUMO Os frutos de Cactaceas do Nordeste Brasileiro têm sido alvo de muitos estudos etnobotânicos e de qualidade funcional. No entanto, ainda há um número considerável de espécies pouco exploradas, como o facheiro (Pilosocereus pachycladus Ritter), planta nativa e de ampla ocorrência e uso na Caatinga. O objetivo desta pesquisa foi avaliar a qualidade, atividade antioxidante e da peroxidase (POD) de frutos do facheiro durante a maturação. Os frutos foram colhidos de áreas de ocorrência de plantas em três estádios de maturação, com base na coloração do epicarpo (V - verde, IP - verde com início de coloração roxa e R - completamente roxo), do município de Pocinhos, Paraíba. Foi realizado um levantamento de termos descritores sensoriais de aparência dos frutos e, em seguida, avaliações físicas, físico-químicas, compostos bioativos, atividade antioxidante e da POD durante a maturação. Os frutos foram descritos como bagas carnosas, com epicarpo liso, formato redondo-achatado, cor roxa opaca, polpa suculenta e macia quando maduros. A qualidade variou durante a maturação, sendo as mudanças mais expressivas as de coloração: tornou-se mais roxa com o avanço da maturação, proporcionando um claro indicador de maturidade. Com a maturação, observou-se um aumento nos conteúdos de betalaínas e polifenóis extraíveis totais, bem como a atividade antioxidante, pela captura do radical DPPH, principalmente na polpa, A polpa do fruto de Pilosocereus pachycladus é uma fonte importante de betalaínas, principalmente betacianinas. Durante a maturação, a atividade da POD diminuiu no pericarpo e aumentou na polpa e foi fortemente correlacionada com a presença de betalaínas e com a atividade antioxidante.

ABSTRACT The fruit of Cactaceas from northeastern Brazil have been the object of many ethnobotanical and functional quality studies. However, a considerable number of species remain poorly exploited, such as the facheiro (Pilosocereus pachycladus Ritter), a native Brazilian plant widely occurring and used in the Caatinga. The objectives of this research were to evaluate the quality, and antioxidant and enzymatic activities of the facheiro fruit during maturation. Fruits were harvested from areas of occurrence of plants in the Paraíba State, Brazil, at three maturity stages, which were determined based on the color of the epicarp (G - green, IP - green with purple traces, and R - completely purple). It was carried out a survey of terms sensorial descriptor terms for fruit appearance and then evaluated the physical, physicochemical, bioactive compounds, antioxidant and peroxidase (POD) activities during maturation. The fruit were described as fleshy berries, with a smooth epicarp; a round, flat shape; opaque purple color; and juicy and soft pulp when ripe. Quality varied during maturation, with the most significant changes being in coloration: the fruit became more purple over time, providing a clear indicator of maturity. With maturation, there was an increase in the content of betalains and total extractable polyphenols, as well as antioxidant activity, by DPPH radical capture method, mainly in the pulp. The pulp of the Pilosocereus pachycladus fruit is an important source of betalains, primarily betacyanins. During maturation, POD activity decreased in the pericarp and increased in the pulp and was strongly correlated with the presence of betalains and with antioxidant activity.

RESUMO O objetivo do presente estudo foi avaliar a toxicidade por contato do óleo essencial de Croton pulegiodorus Baill sobre seis populações de Sitophilus zeamais Motschulsky. As populações de S. zeamais utilizadas apresentam diferentes padrões de susceptibilidade a inseticidas sintéticos e foram provenientes dos municípios de Crixás - GO, Espírito Santo do Pinhal - SP, Juiz de Fora - MG, Picos - PI, Serra Talhada - PE e Vicentina - MT. O óleo essencial foi obtido a partir de plantas coletadas no município de Triunfo - PE, sendo estimadas as concentrações letais (CL50 e CL90), as razões de toxicidade (RT) e as razões de resistência (RR) das populações. A população de Serra Talhada - PE apresentou as menores CL50 (4,21 μL/20g de milho) e CL90 (6,67 μL/20g de milho), sendo considerada padrão de susceptibilidade ao óleo essencial de C. pulegiodorus. Por outro lado, a população de Espírito Santo do Pinhal - SP apresentou as maiores CL50 (6,02 μL/20g de milho) e CL90 (10,55 μL/20g de milho), sendo considerada padrão de tolerância ao óleo. A razão de toxicidade (RT) variou de 1,01 vezes (Picos - PI) a 1,43 vezes (Serra Talhada - PE) enquanto a razão de resistência (RR) variou de 1,13 vezes (Crixás - GO) a 1,43 vezes (Espírito Santo do Pinhal - SP). Observou-se que o óleo essencial de C. pulegiodorus ocasionou redução na emergência de adultos de S. zemais e apresentou efeito residual, pela via de contato, após 30 e 60 dias de aplicação.

ABSTRACT The objective of this work was to evaluate the contact toxicity of essential oil of Croton pulegiodorus Baill on six populations of Sitophilus zeamais Motschulsky. The S. zeamais populations used were from Crixás-GO, Espírito Santo do Pinhal-SP, Juiz de Fora-MG, Picos-PI, Serra Talhada-PE, and Vicentina-MS, Brazil, and present different susceptibility to synthetic insecticides. The essential oil of C. pulegiodorus used was obtained from plants collected in Triunfo-PE, Brazil. The lethal concentrations (LC50 and LC90), toxicity ratio of the essential oil, and the resistance ratio of the populations were estimated. The S. zeamais population from Serra Talhada-PE presented the lowest LC50 (4.21 μL 20 g-1) and LC90 (6.67 μL 20 g-1) and was the reference for susceptibility to the essential oil of C. pulegiodorus. The S. zeamais population from Espírito Santo do Pinhal-SP presented the highest LC50 (6.02 μL 20 g-1) and LC90 (10.55 μL 20 g-1) and was the reference for tolerance to the essential oil of C. pulegiodorus. The toxicity ratio ranged from 1.01 (Picos-PI) to 1.43 (Serra Talhada-PE); and the resistance ratio ranged from 1.13 (Crixás-GO) to 1.43 (Espírito Santo do Pinhal-SP). The essential oil of C. pulegiodorus reduced the emergence of adult S. zemais and showed residual effect, with contact toxicity, after 30 and 60 days of application.

Abstract INTRODUCTION: The recent circulation of arboviruses transmitted by vectors, such as dengue, chikungunya, and Zika, is concerning due to the high morbidity rates, clinical complications, and increased demand on health services. The objective of this study was to analyze the clinical and epidemiological aspects of an epidemic caused by arboviruses in the municipality of Santa Luzia, Minas Gerais, Brazil. METHODS: Longitudinal study of patients with acute febrile disease and suspected arbovirus infection reported to Brazilian Notifiable Disease Information System (Sistema de Informação de Agravos de Notificação) from the epidemiological week 44 of 2015 to epidemiological week 52 of 2016. Patients with confirmed chikungunya were followed-up for 18 months and those with Zika for 15 months. Additionally, we analyzed and described the temporal distribution of confirmed cases of these arboviruses in this municipality. RESULTS: Overall 3,531 arboviruses cases, including 3,481 (98.7%) cases of dengue, 38 (1.0%) cases of chikungunya, and 12 (0.3%) cases of Zika were confirmed. The highest incidence of arbovirus infection occurred in the first quarter of 2016 (epidemiological week 7 to 14). The most frequent symptoms were for dengue, which included fever, headache, retro-orbital pain, and exanthema. Chikungunya infection was associated with fever, myalgia, arthralgia, and rash while Zika infection with pruritus and rash. CONCLUSIONS: Given the similarities in the initial clinical profiles of these arboviruses, it is important to perform a detailed clinical analysis, laboratory diagnosis, and patient follow-up.

ABSTRACT Sugar cane bagasse is a residue of the sugar-alcohol industry, and its main destination is represented by burning boilers for power generation. The bagasse cogeneration of power produces a sugar cane bagasse ash (SCBA) residue that does not have a useful destination. Ashes are commonly studied as pozzolan in Portland cement production. International Standards indicate the use of pozzolan with up to 50% substitution. In the present work, we investigate the use of SCBA as an addition in Portland cement. For this purpose, Portland cement was prepared by substituting cement with 0, 10, 20, and 30% processed SCBA in volume. The ashes were processed by re-burning and grinding and were then characterized by scanning electron microscopy, X-ray diffraction, laser granulometry, X-ray fluorescence spectrometry, the Chapelle method, and pozollanic activity. To evaluate the cement with substitution, we used the mortar recommended by NBR 7215. The mechanical properties of the cements with replacement were analysed through tests of the compressive strength and flexural strength of mortars. The results appear interesting and support the possible use of SCBA in the production of cement from the aspect of mechanical properties evaluated.

OBJECTIVES: to identify the knowledge of users of combined oral contraceptive about correct use, side effects and complications; to verify the correlation between knowledge about the method with age, education, family income and time of use. METHOD: cross-sectional study performed in Fortaleza, Ceará, Brazil, from March to July 2010, with 294 women. Data were collected through interviews. RESULTS: 75% had substantial knowledge about the proper use and side effects and no knowledge about complications. The higher the educational level and family income, the higher the women's knowledge about the correct use of the method. Positive correlation suggests that women who used the method for longer knew more about its side effects. CONCLUSION: there are knowledge gaps about the method, which are influenced by socioeconomic variables and use time.

OBJETIVOS: Identificar el conocimiento de las usuarias de anticonceptivos orales combinados sobre el uso correcto, los efectos secundarios y complicaciones, para verificar la correlación entre el conocimiento sobre el método con la edad, la educación, el ingreso familiar y el tiempo de uso. MÉTODO: Estudio transversal realizado en Fortaleza, Ceará, Brasil, de marzo a julio de 2010, con 294 mujeres. Los datos fueron recolectados a través de entrevistas. RESULTADOS: el 75% tenía un conocimiento considerable sobre el uso adecuado y efectos secundarios y ningún conocimiento acerca de las complicaciones. Cuanto mayor es el nivel educativo y el ingreso familiar, mayor conocimiento de las mujeres sobre el uso correcto del método. La correlación positiva sugiere que las mujeres que utilizaron el método para ya sabían más acerca de sus efectos secundarios. CONCLUSIÓN: Hay lagunas en los conocimientos sobre el método, que son influenciados por variables socioeconómicas y el tiempo de uso.

OBJETIVOS: identificar o conhecimento de usuárias de anticoncepcional oral combinado sobre uso correto, efeitos colaterais e complicações relacionados a esse uso; verificar correlação entre o conhecimento sobre o método com idade, escolaridade, renda familiar mensal e tempo de uso. MÉTODO: estudo transversal, desenvolvido em Fortaleza, Ceará, Brasil, de março a julho de 2010, com 294 mulheres. Os dados foram coletados por meio de entrevista. RESULTADOS: setenta e cinco por cento apresentaram conhecimento substancial para o uso correto e efeitos colaterais e nenhum conhecimento para complicações. Quanto maior a escolaridade e a renda familiar maior o conhecimento das mulheres sobre o uso correto do método. Correlação positiva sugere que mulheres que usaram o método por mais tempo conheciam mais sobre seus efeitos colaterais. CONCLUSÃO: há lacunas no conhecimento sobre o método, sendo essas influenciadas por variáveis socioeconômicas e tempo de uso.

OBJETIVOS: identificar o conhecimento de usuárias de anticoncepcional oral combinado sobre uso correto, efeitos colaterais e complicações relacionados a esse uso; verificar correlação entre o conhecimento sobre o método com idade, escolaridade, renda familiar mensal e tempo de uso. MÉTODO: estudo transversal, desenvolvido em Fortaleza, Ceará, Brasil, de março a julho de 2010, com 294 mulheres. Os dados foram coletados por meio de entrevista. RESULTADOS: setenta e cinco por cento apresentaram conhecimento substancial para o uso correto e efeitos colaterais e nenhum conhecimento para complicações. Quanto maior a escolaridade e a renda familiar maior o conhecimento das mulheres sobre o uso correto do método. Correlação positiva sugere que mulheres que usaram o método por mais tempo conheciam mais sobre seus efeitos colaterais. CONCLUSÃO: há lacunas no conhecimento sobre o método, sendo essas influenciadas por variáveis socioeconômicas e tempo de uso.

OBJECTIVES: to identify the knowledge of users of combined oral contraceptive about correct use, side effects and complications; to verify the correlation between knowledge about the method with age, education, family income and time of use. METHOD: cross-sectional study performed in Fortaleza, Ceará, Brazil, from March to July 2010, with 294 women. Data were collected through interviews. RESULTS: 75% had substantial knowledge about the proper use and side effects and no knowledge about complications. The higher the educational level and family income, the higher the women's knowledge about the correct use of the method. Positive correlation suggests that women who used the method for longer knew more about its side effects. CONCLUSION: there are knowledge gaps about the method, which are influenced by socioeconomic variables and use time.

OBJETIVOS: Identificar el conocimiento de las usuarias de anticonceptivos orales combinados sobre el uso correcto, los efectos secundarios y complicaciones, para verificar la correlación entre el conocimiento sobre el método con la edad, la educación, el ingreso familiar y el tiempo de uso. MÉTODO: Estudio transversal realizado en Fortaleza, Ceará, Brasil, de marzo a julio de 2010, con 294 mujeres. Los datos fueron recolectados a través de entrevistas. RESULTADOS: el 75% tenía un conocimiento considerable sobre el uso adecuado y efectos secundarios y ningún conocimiento acerca de las complicaciones. Cuanto mayor es el nivel educativo y el ingreso familiar, mayor conocimiento de las mujeres sobre el uso correcto del método. La correlación positiva sugiere que las mujeres que utilizaron el método para ya sabían más acerca de sus efectos secundarios. CONCLUSIÓN: Hay lagunas en los conocimientos sobre el método, que son influenciados por variables socioeconómicas y el tiempo de uso.