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ABSTRACT BACKGROUND: Respiratory failure is the most common cause of death in patients with amyotrophic lateral sclerosis (ALS), and morbidity is related to poor quality of life (QOL). Non-invasive ventilation (NIV) may be associated with prolonged survival and QOL in patients with ALS. OBJECTIVES: To assess whether NIV is effective and safe for patients with ALS in terms of survival and QOL, alerting the health system. DESIGN AND SETTING: Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting standards using population, intervention, comparison, and outcome strategies. METHODS: The Cochrane Library, CENTRAL, MEDLINE, LILACS, EMBASE, and CRD databases were searched based on the eligibility criteria for all types of studies on NIV use in patients with ALS published up to January 2022. Data were extracted from the included studies, and the findings were presented using a narrative synthesis. RESULTS: Of the 120 papers identified, only 14 were related to systematic reviews. After thorough reading, only one meta-analysis was considered eligible. In the second stage, 248 studies were included; however, only one systematic review was included. The results demonstrated that NIV provided relief from the symptoms of chronic hypoventilation, increased survival, and improved QOL compared to standard care. These results varied according to clinical phenotype. CONCLUSIONS: NIV in patients with ALS improves the outcome and can delay the indication for tracheostomy, reducing expenditure on hospitalization and occupancy of intensive care unit beds. SYSTEMATIC REVIEW REGISTRATION: PROSPERO database: CRD42021279910 — https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279910.

https://doi.org/10.1590/1516-3180.2022.0470.r1.100423

Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives Discovery Photosensitizers
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Oliveira, Douglas D. S.

; Lapierre, Thibault J. W. Jacques Dit

; Silva, Fernanda C.

; Cunha, Ieda V.

; Souza, Rafael A. C.

; Matos, Patrícia A.

; Almeida, Gustavo M.

; Oliveira, Carolina G.

; Araújo, Thaise G.

; Tsubone, Tayana M.

; Rezende Jr., Celso O.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 1 elocation e-20230128

Abstract: En | Text: En | PDF: En

Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work

https://doi.org/10.21577/0103-5053.20230128

Revisores 2023
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Molas de la Quintana, Adriana Beatriz

; Jimenez Genchi, Alejandro

; Carrizales, Alexia

; Gotti, Amanda

; Martinez Ortiz, Ana

; Rocío Martínez Yacelga, Ana del

; Camilo Ciantelli, Ana Paula

; Jimenez Figueroa, Andres

; Neumann, Angélica Paula

; Parodi Svartman, Bernardo

; Vazquez Rodriguez, Carolina

; Da Silva, Cecilia

; Baroni, Cecilia

; Lanza Perez, Cintia Beatriz

; Mola, Débora

; Alarcón Rubio, David

; Perales Mejia, Felipe de Jesús

; Sarachu, Gerardo

; Gelpi, Gonzalo

; Sosa, Gustavo

; Viana Batista, Helder

; Moizéis, Heloísa Bárbara Cunha

; Carrasco, Jimena

; Ungaretti, Joaquín

; Moreira, Karen

; Tomatis, Karina

; Oros, Laura Beatriz

; Mazaro, Lisabelle Manente

; Chiavone, Luciana

; Perilla Toro, Lyria Esperanza

; Campagnoli, Mabel Alicia

; Ruiz Barbot, Mabela

; Brenlla, María Elena

; Folle Chavannes, María Ana

; Freytes Frey, Marcela

; Rossal, Marcelo

; Ortiz, Maria Victoria

; Nabergoi, Mariela

; Montenegro, Marisela

; Lladó, Mónica

; Freitas De León, Paribanú

; Solís García, Patricia

; Ruiz Santos, Paul

; Fiorati, Regina Célia

; Martins, Rita de Cássia Andrade

; Dominguez-Lara, Sergio Alexis

; Herranz, Silvana Melisa

; Yoma, Solana María

; Gondim, Sonia Maria Guedes

; Rostagnol, Susana

; Wittke, Tommy

; Ballesteros, Virginia

; Tamayo, William

Psicología, Conocimiento y Sociedad

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dec 2023, Volume 13 N. 3 Pages 116 - 118

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.26864/pcs.v13.n3.rev

Definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in amyotrophic lateral sclerosis (ALS): Consensus from ALS and Motor Neuron Disease Scientific Department of the Brazilian Academy of Neurology
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Gondim, Francisco de Assis Aquino

; Pinto, Wladimir Bocca Vieira de Rezende

; Chieia, Marco Antônio Troccoli

; Correia, Carolina da Cunha

; Cunha, Francisco Marcos Bezerra

; Dourado Jr, Mário Emílio Teixeira

; França Júnior, Marcondes Cavalcante

; Marques Júnior, Wilson

; Oliveira, Acary Souza Bulle

; Rodrigues, Cleonisio Leite

; Silva, Delson José da

; Dias-Tosta, Elza

Arquivos de Neuro-Psiquiatria

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aug 2023, Volume 81 N. 8 Pages 764 - 775

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The spectrum of neuropsychiatric phenomena observed in amyotrophic lateral sclerosis (ALS) is wide and not fully understood. Disorders of laughter and crying stand among the most common manifestations. The aim of this study is to report the results of an educational consensus organized by the Brazilian Academy of Neurology to evaluate the definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in ALS patients. Twelve members of the Brazilian Academy of Neurology - considered to be experts in the field - were recruited to answer 12 questions about the subject. After exchanging revisions, a first draft was prepared. A face-to-face meeting was held in Fortaleza, Brazil on 9.23.22 to discuss it. The revised version was subsequently emailed to all members of the ALS Scientific Department from the Brazilian Academy of Neurology and the final revised version submitted for publication. The prevalence of pseudobulbar affect/pathological laughter and crying (PBA/PLC) in ALS patients from 15 combined studies and 3906 patients was 27.4% (N = 1070), ranging from 11.4% to 71%. Bulbar onset is a risk factor but there are limited studies evaluating the differences in prevalence among the different motor neuron diseases subtypes, including patients with and without frontotemporal dementia. Antidepressants and a combination of dextromethorphan and quinidine (not available in Brazil) are possible therapeutic options. This group of panelists acknowledge the multiple gaps in the current literature and reinforces the need for further studies.

Resumo O espectro de fenômenos neuropsiquiátricos observados na ELA é amplo e não completamente entendido. Desordens do riso e do choro estão entre as manifestações mais comuns. O objetivo deste estudo é relatar os resultados de um Consenso organizado pela Academia Brasileira de Neurologia para avaliar definições, fenomenologia, diagnóstico, e manejo dos distúrbios do riso e do choro em pacientes com ELA. Doze membros da Academia Brasileira de Neurologia – considerados experts na área – foram recrutados para responder 12 questões na temática. Depois da verificação das revisões, um primeiro manuscrito foi preparado. Após, foi realizado um encontro presencial em Fortaleza, Brasil, em 23/09/2022, para discussão do conteúdo. A versão revisada foi posteriormente enviada por e-mail para todos os membros do Departamento Científico de DNM/ELA da Academia Brasileira de Neurologia e a versão final revisada foi submetida para publicação. A prevalência da síndrome pseudobulbar em pacientes com ELA em 15 estudos combinados com 3906 pacientes foi de 27,4% (n = 1070), variando entre 11,4% e 71%. Início bulbar é um fator de risco, mas há limitados estudos avaliando as diferenças em prevalência entre os diferentes subtipos de Doença do Neurônio Motor, incluindo pacientes com e sem Demência Frontotemporal. Antidepressivos e uma combinação de dextrometorfana e quinidina (indisponíveis no Brasil) são opções terapêuticas possíveis. Esse grupo de panelistas reconhece as múltiplas demandas não atendidas na literatura atual e reforça a necessidade de futuros estudos.

https://doi.org/10.1055/s-0043-1771176

Radial Nerve Supracondylar Block Versus Fracture Hematoma Block. Comparison of Their Efficacy in Cases of Fractures of the Distal Third of the Radius
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Maia, Guilherme de Albuquerque Souza

; Cunha, Jean Castro

; Feijó, Carolina Queiroz

; Leal, Daniel Mendes

; Moreira, Juan Javier

; Herrero, Carlos Fernando Pereira da Silva

Revista Brasileira de Ortopedia

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aug 2023, Volume 58 N. 4 Pages 557 - 562

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective The present study compares the analgesic efficacy of two techniques to perform non-surgical reduction: fracture hematoma block and radial nerve supracondylar block. Methods Forty patients with fractures of the distal third of the radius, who required reduction, were selected in a quasi-randomized clinical trial to receive one of the anesthetic techniques. All patients signed the informed consent form, except for those who did not wish to participate in the study, had neurological injury, had contraindication to the procedure in the emergency room, or with contraindication to the use of lidocaine. To measure analgesia, the numerical pain rate scale was used at four different moments: preblock, postblock, during reduction, and after reduction; then three differences were calculated: the first between before and after blocking; the second between during reduction and after blockade; and the third between before blocking and after reduction. Results The fracture hematoma and supracondylar block groups showed the following mean values, respectively: 3.90 (1–10) and 3.50 (-6–10) in difference 1; 4.35 (-5–10) and 5.00 (-3–10) in difference 2; and 4.65 (1–10) and 3.80 (-3–10) in difference 3. Conclusion Both techniques proved to be efficient for analgesia, with mild superiority of hematoma block, but without statistical significance.

Resumo Objetivo O estudo compara a eficácia analgésica de duas técnicas para realizar redução incruenta: o bloqueio de hematoma da fratura e o bloqueio supracondilar de nervo radial. Métodos Quarenta pacientes com fraturas do terço distal do rádio, que necessitassem redução, foram selecionados em um ensaio clínico quasi-randomizado, para receber uma das técnicas anestésicas. Todos os pacientes assinaram o termo de consentimento ou assentimento, com exceção daqueles que não desejassem participar do estudo, tivessem lesão neurológica, com contraindicação ao procedimento na sala de emergências, ou com contraindicação ao uso da lidocaína. Para aferir a analgesia foi utilizada a escala numérica da dor em quatro momentos distintos: pré-bloqueio, pós-bloqueio, durante a redução e após a redução; em seguida, foram calculadas três diferenças: a primeira entre antes e após o bloqueio; a segunda entre durante a redução e após o bloqueio; e a terceira entre antes do bloqueio e após a redução. Resultados Os grupos do bloqueio de hematoma de fratura e bloqueio supracondilar apresentaram respectivamente os seguintes valores médios: 3.90 (1–10) e 3.50 (-6–10) na diferença 1; 4.35 (-5–10) e 5.00 (-3–10) na diferença 2; e 4.65 (1–10) e 3.80 (-3–10) na diferença 3. Conclusão As duas técnicas se provaram eficientes para analgesia, com discreta superioridade do bloqueio de hematoma, mas sem significância estatística.

https://doi.org/10.1055/s-0043-1768623

Experimental pain thresholds and psychosocial features across menstrual cycle in myofascial orofacial pain compared to healthy individuals: cross-sectional study
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Herreira-Ferreira, Matheus

; Costa, Yuri Martins

; Cunha, Carolina Ortigosa

; Conti, Ana Claudia de Castro Ferreira

; Conti, Paulo César Rodrigues

; Bonjardim, Leonardo Rigoldi

BrJP

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jun 2023, Volume 6 N. 2 Pages 107 - 112

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND AND OBJECTIVES: The hormonal impact on pain perception during the menstrual cycle is a major focus of study, and further elucidation in temporomandibular disorders (TMD) field is necessary. Thus, this cross-sectional study evaluated experimental pain thresholds, psychosocial features, and clinical pain report on TMD women across menstrual cycle versus healthy controls. METHODS: A total of 220 women’s clinical files were screened, with 80 selected and divided into control group (healthy individuals, n=40) and TMD group (myofascial pain, n=40). Regarding the menstrual cycle phases, the files were divided into Pre-Luteal and Luteal. The Perceived Stress Scale (PSS), Pain Catastrophizing Scale (PCS), Mechanical Pain Threshold (MPT), Wind-up (WUR), Pressure Pain Threshold (PPT), Conditioned Pain Modulation (CPM) and Visual Analogue Scale (VAS) were analyzed at a 5% significance level, by Two-Way ANOVA test and post hoc Tukey test. RESULTS: PSS and PCS were significantly different between TMD and control group (p<0.001), regardless of menstrual cycle. Healthy individuals in the Luteal phase presented higher MPT values compared to the other phases (p<0.001). PPT showed significant difference across menstrual phases (p=0.022), but no differences in multiple comparisons. VAS values showed no difference between menstrual cycle phases (p=0.376). CONCLUSION: Finally, healthy individuals in the Luteal phase have higher MPT and PPT values on the orofacial region. Pain report in patients with TMD showed no difference throughout the menstrual cycle, showing that small alterations on experimental pain thresholds may not be clinically relevant. The presence of chronic pain seems to be more related to psychosocial features than hormonal fluctuations.

RESUMO JUSTIFICATIVA E OBJETIVOS: O impacto do ciclo menstrual na percepção da dor é um foco importante de estudo, sendo necessária uma maior elucidação na disfunção temporomandibular (DTM). Assim, este estudo transversal avaliou limiares de dor experimental, características psicossociais e relatos de dor em mulheres com DTM ao longo do ciclo menstrual, comparadas com controles saudáveis. MÉTODOS: 220 prontuários de mulheres foram analisados, sendo 80 selecionados para os grupos de controle (saudáveis, n=40) e DTM (dor miofascial, n=40). Nas fases do ciclo menstrual, as pacientes foram divididas nas categorias Pré-Luteal e Luteal. Os instrumentos Escala de Estresse Percebido (PSS), Escala de Pensamentos Catastróficos (PCS), Limiar de Dor Mecânica (MPT), Wind-up Ratio (WUR), Limiar de Dor à Pressão (PPT), Modulação Condicionada da Dor (CPM) e Escala analógica visual (EAV) foram analisados com nível de significância de 5%, pelos testes ANOVA de dois fatores e Tukey post hoc. RESULTADOS: As escalas PSS e PCS foram significativamente diferentes entre os grupos DTM e controle (p<0,001), independentemente do ciclo menstrual. Indivíduos saudáveis na fase luteal apresentaram MPT maior em comparação com outras fases (p,0,001). O PPT mostrou diferença significativa entre as fases menstruais (p=0,022), sem diferença nas comparações múltiplas. Os valores da EAV não apresentaram diferença entre as fases menstruais (p=376). CONCLUSÃO: Indivíduos saudáveis na fase luteal têm MPT e PPTl maior na região orofacial. Os relatos de dor em pacientes com DTM não mostraram diferença ao longo do ciclo menstrual, indicando que pequenas alterações nos limiares experimentais podem ser clinicamente relevantes. A presença de dor crônica parece estar mais relacionada com características psicossociais do que com flutuações hormonais.

https://doi.org/10.5935/2595-0118.20230033-en

Parental body mass index and maternal gestational weight gain associations with offspring body composition in young women from the Nutritionists’ Health Study
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Freitas, Renata Germano Borges de Oliveira Nascimento

; Vasques, Ana Carolina Junqueira

; Ribeiro, Francieli Barreiro

; Solar, Isabela

; Hanada, Alfredo Shigueo

; Barbosa, Marina Gomes

; Valente, Angélica Marques Martins

; Pititto, Bianca de Almeida

; Eshriqui, Ilana

; Lopes, Tito Lívio da Cunha

; Geloneze, Bruno

; Ferreira, Sandra Roberta Gouvea

Archives of Endocrinology and Metabolism

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feb 2023, Volume 67 N. 1 Pages 101 - 110

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Intrauterine environment can induce fetal metabolic programming that predisposes to adiposity-related chronic diseases in its lifespan. We examined the associations of parental nutritional status and gestational weight gain with offspring body composition in early adulthood. Materials and methods: This is cross-sectional analysis of female participants of the NutriHS who were submitted to questionnaires, clinical examinations and body composition assessed by DXA. Association of pre-conception parental BMI and maternal gestational weight gain (exposures) with body composition measurements (outcomes) were analyzed using multiple linear models adjusted for Directed Acyclic Graphs-based covariables (maternal and paternal educational level, maternal age, and tobacco, alcohol and/or drugs use). The sample included 124 women (median 28 (24-31) years) with a mean BMI of 25.4 ± 4.7 kg/m2. Results: No association between previous paternal BMI and offspring’s body composition was detected. In the fully adjusted linear regression model, maternal BMI was associated with offspring’s total lean mass (β = 0.66, p = 0.001), appendicular skeletal muscle mass index (ASMI) (β = 0.11, p = 0.003) and fat mass index (FMI) (β = 0.03, p = 0.039). Gestational weight gain was associated with increased offspring’s BMI (OR 1.12 [95% CI 1.02-1.20], p = 0.01). The linear regression model adjusted for maternal age and maternal and paternal education levels showed associations of gestational weight gain with offspring’s ASMI (β = 0.42, p = 0.046), FMI (β = 0.22, p = 0.005) and android-to-gynoid fat ratio (β = 0.09, p = 0.035). Conclusion: Our findings suggest that preconception maternal BMI could influence lean mass and general adiposity of young adult female offspring and that gestational weight gain could be useful for predicting centrally distributed adiposity.

https://doi.org/10.20945/2359-3997000000516

Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH
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Cardoso, Viviane Cunha

; Grandi, Carlos

; Silveira, Rita C.

; Duarte, José Luiz Bandeira

; Viana, Maria Cândida Ferrarez Bouzada

; Ferreira, Daniela Marques de Lima Mota

; Alves Junior, José Mariano Sales

; Embrizi, Laís Furlan

; Gimenes, Carolina Boschi

; Mello e Silva, Nathalia Moura de

; Melo, Fernanda Pegoraro de Godoi

; Venzon, Paulyne Stadler

; Gomez, Dafne Barcala

; Vale, Marynéa Silva do

; Bentlin, Maria Regina

; Barros, Marina Carvalho de Moraes

; Bigélli, Laura Emilia Monteiro

; Diniz, Edna Maria de Albuquerque

; Luz, Jorge Hecker

; Marba, Sérgio Tadeu Martins

; Almeida, João Henrique Carvalho Leme de

; Aragon, Davi Casale

; Carmona, Fabio

Jornal de Pediatria

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jan 2023, Volume 99 N. 1 Pages 86 - 93

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.

https://doi.org/10.1016/j.jped.2022.07.007

EFFECTS OF A SMALL-SIDED SOCCER PROGRAM ON HEALTH PARAMETERS IN OBESE CHILDREN
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Pinho, Carolina Dertzbocher Feil

; Farinha, Juliano Boufleur

; Lisboa, Salime Donida Chedid

; Bagatini, Natália Carvalho

; Leites, Gabriela Tomedi

; Voser, Rogério da Cunha

; Gaya, Anelise Reis

; Reischak-Oliveira, Alvaro

; Cunha, Giovani dos Santos

Revista Brasileira de Medicina do Esporte

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2023, Volume 29 elocation e2021_0398

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: A obesidade infantil está aumentando e, como consequência, gera complicações de saúde decorrentes do comportamento sedentário e baixos níveis de aptidão física. Existem poucos estudos que envolvem crianças, perfis metabólicos e cardiorrespiratórios e futebol. Objetivo: O objetivo foi medir os efeitos de um programa de futebol recreativo reduzido de 12 semanas sobre o risco cardiometabólico e respostas individuais em meninos com sobrepeso ou obesos. Métodos: Treze meninos de 8 a 12 anos (34,9 ± 11,6% de gordura corporal) participaram de um programa de treinamento de futebol recreativo reduzido de 12 semanas com duas sessões de 80 minutos por semana em intensidades acima de 80% da frequência cardíaca máxima. As características antropométricas, a aptidão cardiorrespiratória, o perfil metabólico e as respostas individuais do pico de consumo de oxigênio (VO2pico), carga máxima de trabalho (Wmáx), glicemia e insulina em jejum, HOMA-IR, LDL-C, HDL-C, CT e TG foram medidos pré e pós-treinamento. Resultados: considerando as respostas individuais dos participantes, o treinamento recreativo de futebol foi eficaz para melhorar as variações da potência máxima e do tempo até a exaustão, bem como promover pelo menos uma alteração benéfica nos fatores de risco cardiometabólico em 84% das crianças com sobrepeso ou obesidade. Não houve diferenças entre as características antropométricas pré e pós-programa, perfis metabólicos ou VO2pico. Conclusões: Doze semanas de programas de futebol recreativo reduzido foram capazes de melhorar a potência máxima e a capacidade anaeróbica, bem como manter os níveis de fatores de risco cardiometabólicos em meninos com sobrepeso e obesos. Nível de evidência I; Estudo prospectivo de alta qualidade (todos os pacientes foram inscritos no mesmo estágio da doença, com > 80% dos pacientes inscritos) .

ABSTRACT Introduction: Childhood obesity is increasing and, as a consequence, it generates health complications resulting from sedentary behavior and low levels of physical fitness. There are few studies involving children, metabolic and cardiorespiratory profiles, and soccer. Objective: The purpose was to measure the effects of a 12-week recreational small-sided soccer program on cardiometabolic risk and individual responses to cardiometabolic risk factors in overweight or obese boys. Methods: Thirteen boys aged 8-12 years (34.9±11.6% body fat) participated in a 12-week recreational small-sided soccer training program with two 80-minute sessions per week at intensities over 80% of the maximal heart rate. Anthropometric characteristics, cardiorespiratory fitness, metabolic profile, individual responses to peak oxygen uptake (VO2peak), maximal workload (Wmax), fasting blood glucose, insulin, HOMA-IR, LDL-C, HDL-C, TC, and TG were measured both pre- and post-training. Results: Considering the individual responses of the participants, recreational soccer training was effective in improving variations in maximum power and exhaustion time, as well as promoting at least one beneficial change in cardiometabolic risk factors in 84% of the overweight or obese children. There were no differences between pre- and post-program anthropometric characteristics, metabolic profiles, or VO2peak values. Conclusion: Twelve-week recreational small-sided soccer programs were able to improve maximal power and anaerobic capacity and maintain cardiometabolic risk factor levels in overweight and obese boys. Level of evidence I; High-quality prospective study (all patients were enrolled at the same stage of disease, with >80% of patients enrolled) .

RESUMEN Introdução: La obesidad infantil está aumentando y, como consecuencia, genera complicaciones de salud derivadas del comportamiento sedentario y de los bajos niveles de aptitud física. Existen pocos estudios sobre niños, perfiles metabólicos, cardiorrespiratorios y fútbol. Objetivo: El objetivo fue medir los efectos de un programa de fútbol recreativo reducido de 12 semanas sobre el riesgo cardiometabólico y respuestas individuales en niños con sobrepeso u obesos. Métodos: Trece niños de 8 a 12 años (34,9 ± 11,6% de grasa corporal) participaron en un programa de entrenamiento de fútbol recreativo reducido de 12 semanas con dos sesiones de 80 minutos por semana a intensidades superiores al 80% de la frecuencia cardíaca máxima. Se midieron las características antropométricas, la aptitud cardiorrespiratoria, el perfil metabólico y las respuestas individuales del consumo máximo de oxígeno (VO2pico), la carga de trabajo máxima (Wmax), la glucemia y la insulina en ayunas, HOMA-IR, LDL-C, HDL-C, CT y TG antes y después del entrenamiento. Resultados: Teniendo en cuenta las respuestas individuales, el entrenamiento de fútbol recreativo fue eficaz para mejorar las variaciones de potencia máxima y el tiempo hasta el agotamiento, así como para promover al menos un cambio beneficioso en los factores de riesgo cardiometabólico en el 84% de los niños con sobrepeso u obesidad. No hubo diferencias entre las características antropométricas, los perfiles metabólicos o el pico de VO2 antes y después del programa. Conclusões: Doce semanas de programas de fútbol recreativo reducido fueron capaces de mejorar la potencia máxima y la capacidad anaeróbica, así como de mantener los niveles de factores de riesgo cardiometabólicos en niños con sobrepeso y obesidad. Nível de evidência I; Estudo prospectivo de alta qualidade (todos os pacientes foram inscritos no mesmo estágio da doença, com > 80% dos pacientes inscritos) .

https://doi.org/10.1590/1517-8692202329012021_0398

10.

Coletivos organizados, ativismo social e narrativas da pandemia em territórios vulneráveis na cidade do Rio de Janeiro, Brasil
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Gutiérrez, Adriana Coser

; Campos, Gastão Wagner de Sousa

; Cunha, Marcela Silva da

; Mattos, Mauricio Pereira de

; Costa, Patricia dos Santos da

; Silva, Rafaela Oliveira Lopes da

; Pereira, Ana Carolina dos Santos Rangel

; Campos, Adilson Rocha

; Guerra, Cyntia Amorim

Ciência & Saúde Coletiva

Journal Metrics
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2023, Volume 28 N. 12 Pages 3533 - 3542

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A pandemia de COVID-19 no Brasil atingiu níveis alarmantes. Na cidade do Rio de Janeiro, ela encontrou um cenário de desmonte da Atenção Primária à Saúde (APS) em meio à uma crise política, o que teve grande impacto nos territórios de maior vulnerabilidade. O objetivo desse estudo é analisar de que forma as favelas e equipes da APS organizaram-se para desenvolver ações comunitárias, ocupando espaços deixados pela falta de outras políticas públicas. Os resultados fazem parte da pesquisa qualitativa multicêntrica “Estratégias de abordagem dos aspectos subjetivos e sociais na Atenção Primária no contexto da pandemia”, onde foram analisados documentos orientadores públicos e 36 entrevistas em profundidade com trabalhadores e usuários da APS, organizadas em grades interpretativas. Como resultado, observou-se que houve iniciativas cogestoras dos trabalhadores e usuários da APS, a partir do surgimento de coletivos organizados e ativismo social, para o enfrentamento da pandemia, independente das normativas da Secretaria Municipal de Saúde e demais instâncias governamentais. A APS se apresentou como único equipamento público nos territórios de alta vulnerabilidade, onde a violência armada esteve presente mesmo durante a pandemia.

Abstract The COVID-19 pandemic has reached alarming levels in Brazil. In Rio de Janeiro city, it arrived in a scenario in which Primary Health Care (PHC) was being dismantled in the midst of a political crisis, which had major impact on the most vulnerable territories. This study examined how favelas and PHC teams organised community-based action and occupy the vacuum left by the lack of public policies. The results form part of the multi-centre qualitative study “Strategies for approaching subjective and social aspects of Primary Care in the pandemic context”, using public guidance documents and 36 in-depth interviews of PHC workers and users, which were categorised into interpretive grids. Co-management initiatives by PHC workers and users were found to have arisen out of organised groups and social activism, to face the pandemic, independently of regulations from the Municipal Health Department and other government bodies. PHC figured as the only public facility in highly vulnerable territories, where armed violence was ongoing even during the pandemic.

https://doi.org/10.1590/1413-812320232812.04812023

11.

Ausência de acompanhamento familiar e fatores associados nos partos da zona urbana de uma cidade do sul do Brasil: fato ou ficção?
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de Quadros, Caroline Bender

; de Matos, Mariana Bonati

; Rubin, Bárbara Borges

; Trettim, Jéssica Puchalski

; da Cunha, Gabriela Kurz

; Scholl, Carolina Coelho

; Silva, Kênia Cordeiro

; Vieira, Maria Eduarda Centena Duarte

; Quevedo, Luciana de Avila

; Pinheiro, Ricardo Tavares

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230053

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Verificar a prevalência e identificar os fatores associados à ausência do acompanhante de parto em mulheres no sul do Brasil. Métodos: Trata-se de um estudo transversal, realizado com 466 parturientes, pertencentes a uma coorte de mulheres da zona urbana da cidade de Pelotas, RS. Aos 18 meses pós-parto, foi aplicado um questionário estruturado com dados sociodemográficos, gestacionais e questões relacionadas ao parto. Foi realizada regressão logística para ajustes de possíveis fatores de confusão. Resultados: A prevalência da ausência de acompanhante de parto entre as mulheres foi de 22,3%. As parturientes com até 8 anos de estudo (RP=2,0 [IC95% 1,1–3,8]), que não viviam com um companheiro (RP=2,3 [IC95% 1,2–4,3]), que realizaram o pré-natal no setor público (RP=1,9 [IC95% 1,0–3,7]) e que tiveram um parto via cesárea (RP=6,0 [IC95% 2,9–12,4]) apresentaram maior probabilidade de ausência de acompanhante de parto. Conclusão: Os resultados apontam evidências relevantes para o seguimento da verificação da presença do acompanhante de parto no sul do Brasil, indicando a necessidade de melhor aproveitamento e adesão desta prática. Além disso, a lei que aprova a presença do acompanhante de parto no Brasil parece não estar sendo colocada em prática de modo integral, desrespeitando um direito das parturientes e impactando nos benefícios para a saúde materno-infantil.

ABSTRACT Objective: To verify the prevalence and identify the factors associated with the absence of birth companions among women in Southern Brazil. Methods: This is a cross-sectional study carried out with 466 parturient women in a cohort of women from the urban area of the city of Pelotas, RS. At 18 months postpartum, a structured questionnaire was applied with sociodemographic, gestational data and questions related to childbirth. Logistic regression was performed to adjust for possible confounding factors. Results: The prevalence of the absence of a birth companion among women was 22.3%. Parturient women with up to 8 schooling years (PR=2.0 [95%CI 1.1–3.8]), who did not live with a partner (PR=2.3 [95%CI 1.2–4.3]), who performed their prenatal care in the public sector (PR=1.9 [95%CI 1.0–3.7]) and who had a cesarean delivery (PR=6.0 [95%CI 2.9–12.4]) were more likely to not have had a birth companion. Conclusion: The results shows relevant evidence for the verification of the presence of a companion in Southern Brazil, indicating the need for better use and adherence to this practice. In addition, the law that approves the presence of the birth companion in Brazil does not seem to be being fully implemented, disrespecting a right of parturient women and impacting the benefits for for maternal and child health.

https://doi.org/10.1590/1980-549720230053.2

12.

Health-related quality of life in children with cerebral palsy associated with congenital Zika infection
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Marques, Fernanda Jordão Pinto

; Carvalho, Alessandra Lemos de

; Borigato, Eliana Valverde Magro

; Oliveira, Luiz Felipe Vieira de

; Duarte, Lenamaris Mendes Rocha

; Silva, Adriana Goncalves da

; Amarante, Claret Luiz Dias

; Pereira, Laura Jácome de Melo

; Tavares, Elise Ferreira

; Costa, Lilian Gleice de Sena da

; Alcântara, Carolina Alves Rezende

; Salinas, Andrea Nakamura

; Pinto, Fernanda de Lourdes da Cunha

; Alcântara, Gerliane Carvalho de

; Utsch, Fabiana

; Silva, Cinthia Ramos Diniz

; Reis, Dirlene Araujo dos

; Bessa, Wilerson Marques

; Dutra, Rafaela Christine

; Ventura, Paloma

; Oliveira, Tatiana Souza

Revista Paulista de Pediatria

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2023, Volume 41 elocation e2022016

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To describe the health-related quality of life (QOL) in children with cerebral palsy (CP) associated with congenital Zika infection. Methods: Cross-sectional study of a consecutive series of children, followed in a referral multicentric rehabilitation network in Brazil. We invited the caregivers to respond to the Brazilian version of the Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM) questionnaire. Statistical analysis was performed with the Statistical Package for the Social Sciences (SPSS) 26.0™. We used absolute and relative frequencies for categorical variables and mean and standard deviation for continuous variables. Results: The sample consisted of 193 children, at mean age of 50.3±7.6 months. We observed a predominance of children with cerebral palsy (CP) with Gross Motor Function Classification System (GMFCS) level V (93.7%). Epilepsy (88.4%) was the most common comorbidity. CPCHILDTM mean scores were activities of daily living (ADL)/personal care 43.2±12.6; positioning, transferring and mobility 33.7±16.5; comfort and emotions 84.4±15.2; communication and social interaction (CoSI) 48.2±24.3; health 70.9±17.1; and overall quality of life (OQOL) 72.1±17.1. Total score was 54.8±11.3. Conclusions: Among children with cerebral palsy (CP) related to congenital Zika syndrome, the quality of life (QOL) scores were very similar to other populations with cerebral palsy (CP). The activities of positioning, transferring and mobility had the greatest impact on health-related quality of life (QOL). Rehabilitation strategies and public policies should prioritize aspects related to mobility for this population.

RESUMO Objetivo: Descrever a qualidade de vida relacionada à saúde em crianças com paralisia cerebral associada à infecção congênita pelo zika. Métodos: Estudo transversal de série consecutiva de casos de crianças acompanhadas em uma rede multicêntrica de reabilitação no Brasil. Convidamos o(s) cuidador(es) a responder à versão brasileira do Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM). A análise estatística foi realizada com o pacote estatístico Statistical Package for the Social Sciences (SPSS) 26.0™. Para variáveis categóricas, foram utilizadas frequências absolutas e relativas e, para variáveis contínuas, média e desvio padrão. Resultados: Cento e noventa e três crianças, com idade média de 50,3±7,6 meses, foram incluídas. Observou-se predomínio de crianças com paralisia cerebral Gross Motor Function Classification System (GMFCS) nível V (93,7%). Epilepsia (88,4%) foi a comorbidade mais comum. As pontuações médias do CPCHILDTM foram: atividades de vida diária/cuidados pessoais 43,2±12,6; posicionamento, transferência e mobilidade 33,7±16,5; conforto e emoções 84,4±15,2; comunicação e interação social 48,2±24,3; saúde 70,9±17,1; e qualidade de vida geral 72,1±17,1. A pontuação total foi 54,8±11,3. Conclusões: Entre as crianças com paralisia cerebral relacionada à síndrome do zika congênita, as atividades de posicionamento, transferência e mobilidade tiveram maior impacto na qualidade de vida relacionada à saúde, semelhantemente a outras etiologias de paralisia cerebral. As estratégias de reabilitação e as políticas públicas devem priorizar os aspectos relacionados à mobilidade dessa população.

https://doi.org/10.1590/1984-0462/2023/41/2022016

13.

Relationship between microcephaly and indicators of social inequality in the state of Paraíba, Brazil
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Bezerra, Anna Carolina D’ucarmo

; Vasconcelos, Manuela Leitão de

; Lima Filho, Luiz Medeiros Araujo

; Cunha, Daniele Andrade da

; Alves, Giorvan Ânderson dos Santos

; Pernambuco, Leandro

einstein (São Paulo)

Journal Metrics
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2023, Volume 21 elocation eAO0043

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To analyze the relationship between microcephaly and social inequality indicators in the state of Paraíba during the biennium January 2015 and December 2016. Methods Ecological study with data from newborn microcephaly records and municipal socioeconomic, environmental, and demographic indicators was conducted using two health information systems from the Brazilian Ministry of Health (SINASC and SINAN) and the Brazilian Institute of Geography and Statistics. A Poisson multiple regression model was applied with a significance level of 5%. Results Among 223 municipalities in Paraíba, 74 registered new cases of microcephaly. The number of Zika virus cases, number of inhabitants, number of households without adequate water supply, and household income were predictor variables of the number of new cases of microcephaly in Paraíba. Conclusion Microcephaly is associated with indicators of social inequality in Paraíba. Zika virus cases, water supply, and family income are the indicators that best explain the increase in microcephaly cases. Therefore, these variables must be monitored by health professionals and authorities.

https://doi.org/10.31744/einstein_journal/2023ao0043

14.

AVÓS CUIDADORES DE NETOS: ANÁLISE DO PERFIL E INTENSIDADE DOS CUIDADOS
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Bragato, Aline Guarato da Cunha

; Garcia, Luan Augusto Alves

; Camargo, Fernanda Carolina

; Paula, Fabiana Fernandes Silva de

; Malaquias, Bruna Sthephanie Sousa

; Elias, Henrique Ciabotti

; Santos, Álvaro da Silva

Cogitare Enfermagem

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2023, Volume 28 elocation e79812

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to identify the profile and intensity of the care provided by grandparents to grandchildren. Method: a descriptive and cross-sectional study by means of systematized random sampling, with application of a semi-structured questionnaire and execution of descriptive exploratory analysis. It was conducted in 2019 in the municipality of Triângulo Mineiro - Brazil. Results: a total of 392 grandparents caring for grandchildren were interviewed, mostly women (87.5%), retired (67.3%), with incomplete Elementary School (52.8%), hypertensive (71.9%) and with vision problems (69.4%). The main reason for the caregiver role was the fact that the parents had to work, and intensity of the care provided to the grandchildren was high. Conclusion: it is considered that the care relationship between grandparents and grandchildren is an invisible aspect to the scientific production and in the structuring of health programs, despite its impacts on older adults’ health status. The study broadens their visibility, with the need to unveil this topic so that it is possible to integrate them and strengthen public and social policies, especially in the health sector, given that it is an emerging phenomenon.

RESUMEN Objetivo: identificar el perfil y la intensidad del cuidado que realizan los abuelos de sus nietos. Método: estudio descriptivo, transversal, con muestreo aleatorio sistemático, mediante cuestionario semiestructurado y análisis descriptivo exploratorio. Realizado en el municipio del Triángulo Minero - Brasil, 2019. Resultados: se entrevistó a 392 abuelos que cuidaban a sus nietos, la mayoría eran mujeres (87,5 %), jubiladas (67,3 %), con primaria incompleta (52,8 %), hipertensión (71,9 %) y problemas visuales (69,4 %). La principal razón para que cuiden de ellos era que los padres trabajaban y la intensidad del cuidado de los nietos era intensiva. Conclusión: se considera que la relación de cuidado entre abuelos y nietos es un aspecto invisible en la producción científica y en la estructuración de programas de salud, a pesar de los impactos que tiene en la condición de salud de los adultos mayores. El estudio amplía la visión sobre los mismos dado que es necesario dilucidar este tema para que puedan ser efectivamente integrados y fortalecer las políticas públicas y sociales, especialmente en el sector salud, dado que se trata de un fenómeno emergente.

RESUMO Objetivo: identificar o perfil e a intensidade de cuidado dos avós para com os netos. Método: estudo descritivo, transversal, por amostra aleatória sistematizada, utilizado questionário semiestruturado e empreendida análise exploratória descritiva. Realizado no município do Triângulo Mineiro - Brasil, 2019. Resultados: entrevistados 392 avós cuidadores de netos, maioria mulheres (87,5%), aposentadas (67,3%), ensino fundamental incompleto (52,8%), hipertensas (71,9%) e problemas visuais (69,4%). O motivo principal de cuidado foi pelos pais trabalharem e a intensidade de cuidado junto aos netos foi intensiva. Conclusão: considera-se que a relação de cuidado entre avos e netos é um aspecto invisível à produção científica e na estruturação de programas de saúde, apesar de seus impactos à condição de saúde dos idosos. O estudo amplia a visão aos mesmos sendo necessário o desvelar deste tema para que se possa efetivamente integrá-los e fortalecer políticas públicas e sociais, notadamente no setor saúde, dado ser um fenômeno emergente.

https://doi.org/10.1590/ce.v28i0.79812

15.

Which social, gestational and mental health aspects are associated to maternal-fetal attachment?
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Rubin, Bárbara Borges

; Matos, Mariana Bonati de

; Trettim, Jéssica Puchalski

; Scholl, Carolina Coelho

; Cunha, Gabriela Kurz da

; Curcio, Eduarda

; Stigger, Rafaelle Stark

; Martins, Clarissa de Souza Ribeiro

; Motta, Janaína Vieira dos Santos

; Ghisleni, Gabriele

; Pinheiro, Ricardo Tavares

; Quevedo, Luciana de Avila

Revista Brasileira de Saúde Materno Infantil

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2023, Volume 23 elocation e20220361

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objectives: this study aimed to explore a set of factors associated with lower maternal-fetal attachment (MFA) in pregnant women. Methods: this is a cross-sectional study corresponding to the second wave of a cohort study with a population-based sample of pregnant women in the South of Brazil. The maternal-fetal attachment scale (MFAS) was used to measure MFA. Bivariate analysis was performed using the t-test and ANOVA. The variables that presented p<0.20 were taken for multivariate analysis, through linear regression, in order to control possible confounding factors. Results: a total of 840 pregnant women were included. Pregnant women who had lower MFA means were those who did not live with a partner (B=-3.8 [CI95%=-6.0; -1.7]), those between the first and second trimester of pregnancy (B=-4.3 [CI95%=-5.9; -2.6]), those who did not have support from their mother during pregnancy (B=-2.4 [CI95%=-4.6; -0.2]), and those with depressive symptoms (B=-4.9 [CI95%=-7.4; -2.5]). Conclusions: the results showed that a higher MFA it is associated with an adequate support network during pregnancy, better maternal mental health, and with an advanced pregnancy. Early evaluation of MFA and effort to promote an adequate prenatal bond, focusing on maternal psychological and emotional aspects are strongly suggested.

Resumo Objetivos: explorar um conjunto de fatores associados ao menor apego materno-fetal (AMF) em gestantes. Métodos: trata-se de um estudo transversal, correspondente à segunda fase de um estudo de coorte com uma amostra de base populacional de gestantes no sul do Brasil. Foi utilizada a Escala de Apego Materno-Fetal (EAMF) para medir o AMF. A análise bivariada foi realizada através do teste t e ANOVA. As variáveis que apresentaram p<0,20 foram levadas para análise multivariada, por meio de regressão linear, a fim de controlar possíveis fatores de confusão. Resultados: foram incluídas 840 gestantes. As gestantes que apresentaram menores médias de AMF foram aquelas que não moravam com um companheiro (B=-3,8 [IC95%=-6,0; -1,7]), que estavam entre o primeiro e o segundo trimestre de gestação (B=-4,3 [IC95%=-5,9; -2,6]), que não tiveram o apoio da mãe durante a gestação (B=-2,4 [IC95%=-4,6; -0,2]) e que apresentaram sintomas depressivos (B=-4,9 [IC95%=-7,4; -2,5]). Conclusões: os resultados mostraram que um maior AMF está associado a presença de uma rede de apoio adequada na gravidez, melhor saúde mental materna e a uma gestação avançada. A avaliação precoce do AMF e a promoção de um vínculo pré-natal adequado, com foco nos aspectos psicológicos e emocionais maternos são fortemente sugeridos.

https://doi.org/10.1590/1806-9304202300000361-en

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